cGMP inhibits GTP cyclohydrolase I activity and biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells

Journal of Pharmacological Sciences

Volumn 93, Issue 3, 2003, Pages 265-271

  Shiraishi, Hiroaki ^a   Kato, Taiya ^a   Atsuta, Koji ^a   Sumi Ichinose, Chiho ^a   Ohtsuki, Masatsugu ^a   Itoh, Mitsuyasu ^a   Hishida, Hitoshi ^a   Tada, Shin ^a   Udagawa, Yasuhiro ^a   Nagatsu, Toshiharu ^b   Hagino, Yasumichi ^a   Ichinose, Hiroshi ^b   Nomura, Takahide ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

cGMP; Endothelial cell; GTP cyclohydrolase I; Nitric oxide; Tetrahydrobiopterin

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 (4 CARBOXYPHENYL) 4,4,5,5 TETRAMETHYLIMIDAZOLINE 1 OXYL 3 OXIDE; 4 ETHYL 2 HYDROXYIMINO 5 NITRO 3 HEXENAMIDE; 8 (4 CHLOROPHENYLTHIO)GUANOSINE 3',5' CYCLIC MONOPHOSPHOROTHIOATE; 8 BROMO CYCLIC AMP; 8 BROMO CYCLIC GMP; CYCLIC AMP DERIVATIVE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC GMP DERIVATIVE; CYCLOHEXIMIDE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; ISOBUTYLMETHYLXANTHINE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

ARTICLE; CELL LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INFLAMMATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SYNTHESIS INHIBITION; SHORT COURSE THERAPY; SIGNAL TRANSDUCTION; UMBILICAL VEIN;

BIOPTERIN; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ENZYME INHIBITORS; GTP CYCLOHYDROLASE; HUMANS; UMBILICAL VEINS;

EID: 10744231434     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.93.265     Document Type: Article

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