cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells

Life Sciences

Volumn 70, Issue 18, 2002, Pages 2187-2198

  Ohtsuki, Masatsugu ^a   Shiraishi, Hiroaki ^a   Kato, Taiya ^a   Kuroda, Risa ^a   Tazawa, Masahiro ^a   Sumi Ichinose, Chiho ^a   Tada, Shin ^a   Udagawa, Yasutoshi ^a   Itoh, Mitsuyasu ^a   Hishida, Hitoshi ^a   Ichinose, Hiroshi ^a   Nagatsu, Toshiharu ^a   Hagino, Yasumichi ^a   Nomura, Takahide ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

cAMP; Cytokine; GTP cyclohydrolase I (GCHI); Human umbilical vein endothelial cells (HUVEC); mRNA; Tetrahydrobiopterin (BH4)

Indexed keywords

8 BROMO CYCLIC AMP; BUCLADESINE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYTOKINE; FORSKOLIN; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; ILOPROST; MESSENGER RNA; PROSTACYCLIN; TETRAHYDROBIOPTERIN;

ARTICLE; BIOSYNTHESIS; CIRCULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLAMMATION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; STIMULATION; UMBILICAL VEIN;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; BIOPTERIN; BUCLADESINE; CELLS, CULTURED; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FORSKOLIN; GTP CYCLOHYDROLASE; HUMANS; ILOPROST; INFANT, NEWBORN; INTERFERON TYPE II; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS;

EID: 18344386385     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)01503-5     Document Type: Article

References (39)

1. Availability of tetrahydrobiopterin is not a factor in the inability to detect nitric oxide production by human macrophages
2. Tetrahydrobiopterin is required for cytokine-induced nitric oxide production in a murine macrophage cell line (RAW 264)
3. Tetrahydrobiopterin and cytokines
4. Modulation of human endothelial cell tetrahydrobiopterin synthesis by activating and deactivating cytokines: New perspectives on endothelium-derived relaxing factor
5. Pteridine biosynthesis in human endothelial cells: Impact on nitric oxide-mediated formation of cyclic GMP
6. Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells
7. Parallel induction of nitric oxide and tetrahydrobiopterin synthesis by cytokines in rat glial cells
8. Tetrahydrobiopterin biosynthesis in C6 glioma cells: Induction of GTP cyclohydrolase I gene expression by lipopolysaccharide and cytokine treatment
9. Pyrrolidine dithiocarbamate inhibits immunostimulant-induced tetrahydrobiopterin synthesis in rat vascular smooth muscle
10. Tetrahydrobiopterin synthesis precedes nitric oxide-dependent inhibition of insulin secretion in INS-1 rat pancreatic β-cells
11. Induction of tetrahydrobiopterin synthesis in rat cardiac myocytes: Impact on cytokine-induced NO generation
12. Coexpression of GTP cyclohydrolase I and inducible nitric oxide synthase mRNAs in mouse osteoblastic cells activated by proinflammatory cytokines
13. In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide
14. Tetrahydrobiopterin as another EDRF in man
15. GTP cyclohydrolase I mRNA induction and tetrahydrobiopterin synthesis in human endothelial cells
16. Cytokines stimulate GTP cyclohydrolase I gene expression in cultured human umbilical vein endothelial cells
17. Evidence for involvement of the proteasome complex (26S) and NF κ B in IL-1β-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells
18. Culture of human endothelial cells derived from umbilical veins: Identification by morphologic and immunologic criteria
19. Analysis of reduced forms of biopterin in biological tissues and fluids
20. A sensitive assay of GTP cyclohydrolase I activity in rat and human tissues using radioimmunoassay of neopterin
21. Enzymes related to catecholamine biosynthesis in Tetrahymena pyriformis: Presence of GTP cyclohydrolase I
22. 15N] nitrate in biological fluids
23. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye-binding
24. Isolation of full length cDNA clone for human GTP cyclohydrolase I type 1 from pheochromocytoma
25. Species and tissue specificity of mammalian GTP cyclohydrolase I messenger RNA
26. Sodium butyrate induces tyrosine phosphorylation and activation of MAP kinase (ERK-1) in human K562 cells
27. Inhibition by sodium butyrate of enzyme induction by glucocorticoids and dibutyryl cyclic AMP: A role for the rapid form of histone acetylation
28. Role of tetrahydrobiopterin availability in the regulation of nitric-oxide synthase expression in human mesangial cells
29. Coordinate induction of tetrahydrobiopterin synthesis and nitric oxide synthase activity in chicken macrophages: Upregulation of GTP-cyclohydrolase I activity
30. Differential expression of iNOS and cNOS mRNA in human vascular smooth muscle cells and endothelial cells under normal and inflammatory conditions
31. Tetrahydrobiopterin biosynthesis, regeneration and functions
32. Stimulation of in vitro angiogenesis by tetrahydrobiopterin in bovine aortic endothelial cells
33. Role of nuclear factor κ B in cytokine-induced nitric oxide and tetrahydrobiopterin synthesis in rat neonatal cardiac myocytes
34. Tumor necrosis factor (TNF)-α activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase
35. ras-dependent manner
36. Characterization of mouse and human GTP cyclohydrolase I genes: Mutations in patients with GTP cyclohydrolase I deficiency
37. Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat GTP cyclohydrolase I gene
38. Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells
39. Phosphorylation of GTP cyclohydrolase I and modulation of its activity in rodent mast cells