Cariporide is cardioprotective after iatrogenic ventricular fibrillation in the intact swine heart

Annals of Thoracic Surgery

Volumn 76, Issue 4, 2003, Pages 1264-1269

  Rabkin, David G ^a   Cabreriza, Santos E ^a   Cheema, Faisal H ^a   Hill, Adam A ^a   Curtis, Lauren J ^a   Sciacca, Robert R ^a   Mosca, Ralph S ^a   Spotnitz, Henry M ^a   Jacobs, Marshall L ^b   Del Nido, Pedro J ^b  

^a Columbia Coll of Phys and Surgeons ^*  (United States)

^b PH 1422 ^*

Author keywords

[No Author keywords available]

Indexed keywords

CARIPORIDE; PROTEIN INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN;

ANALYTICAL ERROR; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA FLOW; ARTICLE; AUTOPSY; CONTROLLED STUDY; DEFIBRILLATOR; DIASTOLE; DISEASE COURSE; ECHOCARDIOGRAPHY; FUNCTIONAL ASSESSMENT; HEART CONDUCTION; HEART EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE; HEART MUSCLE REPERFUSION; HEART PRELOAD; HEART PROTECTION; HEART STROKE VOLUME; HEART VENTRICLE COMPLIANCE; HEART VENTRICLE FIBRILLATION; HEART WORK; HIGH RISK PATIENT; IATROGENIC DISEASE; IMPLANTATION; IN VIVO STUDY; MALE; MEASUREMENT; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; PROPHYLAXIS; STANDARD; SWINE; SYSTOLE; WATER CONTENT;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; DEFIBRILLATORS, IMPLANTABLE; GUANIDINES; IATROGENIC DISEASE; MALE; SULFONES; SWINE; VENTRICULAR FIBRILLATION;

EID: 10744229937     PISSN: 00034975     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-4975(03)00826-9     Document Type: Article

References (17)

1. Winkle RA, Mead RH, Ruder MA, et al. Ten-year experience with implantable defibrillators. Circulation 1991;84:II-426.
2. + exchange inhibition preserves ventricular function after ventricular fibrillation in the intact swine heart. J Thorac Cardiovasc Surg 2003;125:1499-509.
3. Theroux P, Chaitman BR, Danchin N, et al. Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Circulation 2000;102:3032-8.
4. Rupprecht H-J, vom Dahl J, Terres W, et al. Cardioprotective effects of the Na(+)/H(+) exchange inhibitor cariporide in patients with acute anterior myocardial infarction undergoing direct PTCA. Circulation 2000;101:2902-8.
5. I load after ischemia, and improves function in intact hearts. Am J Heart Circ Physiol 2001;281:H2398-H2409.
6. Kumar S, Haery C, Parrillo JE. Myocardial dysfunction in septic shock. Crit Care Clin 2000;16:251-87.
7. Shipolini AR, Galiñanes M, Edmondson SJ, et al. Na/H exchange inhibitor HOE-642 improves cardioplegic myocardial preservation under both normothermic and hypothermic conditions. Circulation 1997;96(9 Suppl):II-266-73.
8. Kevelaitis E, Oub E, Naissa A, et al. Ischemic preconditioning with opening of mitochondrial adenosine triphosphate-sensitive potassium channels or Na/H exchange inhibition: which is the best protective strategy for heart transplants? J Thorac Cardiovasc Surg 2001;121:155-62.
9. Portman MA, Panos AL, Xiao Y, et al. HOE-642 (cariporide) alters pH(i) and diastolic function after ischemia during reperfusion in pig hearts in situ. Am J Physiol Heart Circ Physiol 2001;280:H830-4.
10. Kern KB. Myocardial dysfunction after resuscitation from cardiac arrest; an example of global myocardial stunning. J Am Coll Cardiol 1996;28:232-40.
11. Gazmuri RJ, Berkowitz M, Cajigas H. Myocardial effects of ventricular fibrillation in the isolated rat heart. Crit Care Med 1999;27:1542-50.
12. 2+ responsiveness and altered diastolic function in intact ventricular muscle. Circ Res 1995;76:1036-48.
13. Gazmuri RJ, Ayoub A, Hoffner E, et al. Successful ventricular defibrillation by the selective sodium-hydrogen exchange isoform-1 inhibitor cariporide. Circulation 2001;104:234-9.
14. Xie J, Weil MH, Sun S, et al. High-energy defibrillation increases the severity of postresuscitation myocardial dysfunction. Circulation 1997;96:683-8.
15. Doherty PW, McLaughlin PR, Billingham M, et al. Cardiac damage produced by direct current countershock applied to the heart. Am J Cardiol 1979;43:225-32.
16. Kerber RE, Partins JB, Gascho JA, et al. Effect of direct-current counter-shocks on regional myocardial contractility and perfusion: experimental studies. Circulation 1981;63:323-32.
17. Park WM, Amirhamzeh MMR, Jia CX, et al. Systolic arterial pressure recovery after ventricular fibrillation/flutter in humans. Pacing Clin Electrophysiol 1994;17:1100-6.