Characterization and purification of the vitamin K1 2,3 epoxide reductase system from rat liver

Journal of Pharmacy and Pharmacology

Volumn 53, Issue 4, 2001, Pages 481-486

  Begent, L A ^a   Hill, A P ^b   Steventon, G B ^a   Hutt, A J ^a   Pallister, C J ^b   Cowell, D C ^b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF THE WEST OF ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; DISULFIDE; OXIDOREDUCTASE; PHYTOMENADIONE OXIDE; QUINONE DERIVATIVE; THIOL; VITAMIN K GROUP; WARFARIN;

ANIMAL TISSUE; ARTICLE; CATALYSIS; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); DRUG PROTEIN BINDING; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME KINETICS; ENZYME PURIFICATION; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE; LIVER MICROSOME; NONHUMAN; OXIDATION REDUCTION REACTION; PROTEIN PROTEIN INTERACTION; RAT; VITAMIN METABOLISM;

ANIMALS; BENZOQUINONES; BINDING SITES; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENDOPLASMIC RETICULUM; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; RATS; VITAMIN K 1; WARFARIN;

EID: 0035028584     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357011775776     Document Type: Article

References (23)

1. A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principal of protein-dye binding
2. Assembly of the warfarin-sensitive vitamin K 2,3-epoxide reductase complex in the endoplasmic reticulum membrane
3. The relationship between inhibition of vitamin K 2,3 epoxide reductase and reduction of the clotting factor activity with warfarin
4. A comparison of human prothrombin factor IX (Christmas factor), factor X (Stuart factor), and protein S
5. Vitamin K epoxide and quinone reductase activities evidence for reduction by a common enzyme
6. 1) in rat liver
7. Tissue distribution and warfarin sensitivity of vitamin K1 2,3 epoxide reductase
8. Metabolism of vitamin K and vitamin K 2,3 epoxide via interactions with a common disulfide
9. Purification of vitamin K epoxide reductase that catalyzes conversion of vitamin K1 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone
10. Blood coagulation pathway
11. Is thioredoxin the physiological vitamin K epoxide reducing agent?
12. The isolation of a warfarin-sensitive protein from bovine plasma
13. Mechanism of action of coumarins
14. Annotation: Vitamin K and vitamin K dependent proteins
15. 1): Dose response relationships in man
16. Stimulation of the dithiol-dependent reductases in the vitamin K cycle by the thioredoxin
17. A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterisation
18. Vitamin K dependent modifications of glutamic acid residues in prothrombin
19. Recent advances in hepatic vitamin K metabolism and function
20. Vitamin K metabolism and vitamin K1 status in human liver samples: A search for the inter-individual differences in warfarin sensitivity
21. 1 and related compounds
22. Purification of warfarin sensitive vitamin K 2,3 epoxide reductase