-
1
-
-
0029164564
-
ZD1694 (Tomudex): A new thymidylate synthase inhibitor with activity in colorectal cancer
-
Jackman, A. L., Farrugia, G. A., and Gibson, W. ZD1694 (Tomudex): a new thymidylate synthase inhibitor with activity in colorectal cancer. Eur. J. Cancer, 31A: 1277-1282, 1995.
-
(1995)
Eur. J. Cancer
, vol.31 A
, pp. 1277-1282
-
-
Jackman, A.L.1
Farrugia, G.A.2
Gibson, W.3
-
2
-
-
0025997350
-
ICI DI 1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor growth in vitro and in vivo: A new agent for clinical study
-
Jackman, A. L., Taylor, G. A., and Gibson, W. ICI DI 1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor growth in vitro and in vivo: a new agent for clinical study. Cancer Res., 51: 5579-5586, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 5579-5586
-
-
Jackman, A.L.1
Taylor, G.A.2
Gibson, W.3
-
3
-
-
0024316466
-
DNA topoisomerase poisons as antitumor drugs
-
Liu, L. DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem., 58: 351-375, 1989.
-
(1989)
Annu. Rev. Biochem.
, vol.58
, pp. 351-375
-
-
Liu, L.1
-
4
-
-
0027146423
-
In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin
-
Pendyala, L., and Creaven, P. J. In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin. Cancer Res., 53: 5970-5976, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 5970-5976
-
-
Pendyala, L.1
Creaven, P.J.2
-
5
-
-
0000269364
-
Raltitrexed (Tomudex) versus 5-fluorouracil and leucovorin (5-FU + LV) in patients with advanced colorectal cancer (ACC): Results of a randomized, multicenter, North American trial
-
Pazdur, R., and Vincent, M., for the Tomudex Colorectal Cancer Study Group. Raltitrexed (Tomudex) versus 5-fluorouracil and leucovorin (5-FU + LV) in patients with advanced colorectal cancer (ACC): results of a randomized, multicenter, North American trial. Proc. Am. Soc. Chn. Oncol., 16: 801, 1997.
-
(1997)
Proc. Am. Soc. Chn. Oncol.
, vol.16
, pp. 801
-
-
Pazdur, R.1
Vincent, M.2
-
6
-
-
0000152038
-
Advanced colorectal cancer (ACC): Results from the latest Tomudex (raltitrexed) comparative study
-
Harper, P., on behalf of the Tomudex Study Group. Advanced colorectal cancer (ACC): results from the latest Tomudex (raltitrexed) comparative study. Proc. Am. Soc. Clin. Oncol., 16: 802, 1997.
-
(1997)
Proc. Am. Soc. Clin. Oncol.
, vol.16
, pp. 802
-
-
Harper, P.1
-
7
-
-
0029966672
-
Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer
-
Rothenberg, M. L., Eckardt, J. R., Kuhn, J. G., Bums, H. A., III, Nelson, J., Hilsenbeck, S. G., Rodriguez, G. I., Thurman, A. M., Smith, L. S., Eckhardt, S. G., Weiss, G. R., Elfring, G. L., Rinaldi, D. A., Schaaf, L. J., and Von-Hoff, D. D. Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer. J. Clin. Oncol., 14: 1128-1135, 1996.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 1128-1135
-
-
Rothenberg, M.L.1
Eckardt, J.R.2
Kuhn, J.G.3
Bums III, H.A.4
Nelson, J.5
Hilsenbeck, S.G.6
Rodriguez, G.I.7
Thurman, A.M.8
Smith, L.S.9
Eckhardt, S.G.10
Weiss, G.R.11
Elfring, G.L.12
Rinaldi, D.A.13
Schaaf, L.J.14
Von-Hoff, D.D.15
-
8
-
-
0031014627
-
Phase II study of irinotecan in treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy
-
Rougier, P., Bugat, R., Douillard, J. Y., Culine, S., Suc, E., Brunet, P., Becouarn, Y., Ychou, M., Marty, M., Extra, J. M., Bonneterre, J., Adenis, A., Seitz, J. F., Ganem, G., Namer, M., Conroy, T., Negrier, S., Merrouche, Y., Burki, F., Mousseau, M., Herait, P., and Mahjoubi. M. Phase II study of irinotecan in treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy. J. Clin. Oncol., 15: 251-260, 1997.
-
(1997)
J. Clin. Oncol.
, vol.15
, pp. 251-260
-
-
Rougier, P.1
Bugat, R.2
Douillard, J.Y.3
Culine, S.4
Suc, E.5
Brunet, P.6
Becouarn, Y.7
Ychou, M.8
Marty, M.9
Extra, J.M.10
Bonneterre, J.11
Adenis, A.12
Seitz, J.F.13
Ganem, G.14
Namer, M.15
Conroy, T.16
Negrier, S.17
Merrouche, Y.18
Burki, F.19
Mousseau, M.20
Herait, P.21
Mahjoubi, M.22
more..
-
9
-
-
0028036652
-
Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucoverin) in patients with colorectal cancer metastases: A randomized multi-institutional trial
-
Levi, F. A., Zidanil R., Vannetzel, J. M., Perpoint, B., Focan, C., Faggiuolo, R., Chollet, P., Garufi, C., Itzhaki, M., Dogliotti, L., Iacobetti, S., Adam, R., Kunstlinger, F., Gastiaburu, J., Bismuth, H., Josmin, C., and Misset, J. L. Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucoverin) in patients with colorectal cancer metastases: a randomized multi-institutional trial. J. Natl. Cancer Inst., 86: 1608-1617, 1994.
-
(1994)
J. Natl. Cancer Inst.
, vol.86
, pp. 1608-1617
-
-
Levi, F.A.1
Zidanil, R.2
Vannetzel, J.M.3
Perpoint, B.4
Focan, C.5
Faggiuolo, R.6
Chollet, P.7
Garufi, C.8
Itzhaki, M.9
Dogliotti, L.10
Iacobetti, S.11
Adam, R.12
Kunstlinger, F.13
Gastiaburu, J.14
Bismuth, H.15
Josmin, C.16
Misset, J.L.17
-
10
-
-
0012797224
-
Two consecutive Phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines
-
Machover, D., Diaz-Rubio, E., de Gramont, A., Schilf, A., Gastiaburu, J-J., Brienza, S., Itzhaki, M., Metzger, G., N'Daw, D., Vignoud, J., Abad, A., Francois, E., Gamelin, E., Marty, M., Sastre, J., Seitz, J. F., and Ychou, M. Two consecutive Phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines. Ann. Oncol., 7: 95-98, 1996.
-
(1996)
Ann. Oncol.
, vol.7
, pp. 95-98
-
-
Machover, D.1
Diaz-Rubio, E.2
De Gramont, A.3
Schilf, A.4
Gastiaburu, J.-J.5
Brienza, S.6
Itzhaki, M.7
Metzger, G.8
N'Daw, D.9
Vignoud, J.10
Abad, A.11
Francois, E.12
Gamelin, E.13
Marty, M.14
Sastre, J.15
Seitz, J.F.16
Ychou, M.17
-
11
-
-
0030888321
-
Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer
-
de Gramont, A., Vignoud, J., Tournigand, C., Louvet, C., André, T., Varette, C., Raymond, E., Moreau, S., Le Bail, N., and Krulik, M. Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer. Eur. J. Cancer, 33: 214-219, 1997.
-
(1997)
Eur. J. Cancer
, vol.33
, pp. 214-219
-
-
De Gramont, A.1
Vignoud, J.2
Tournigand, C.3
Louvet, C.4
André, T.5
Varette, C.6
Raymond, E.7
Moreau, S.8
Le Bail, N.9
Krulik, M.10
-
12
-
-
0008461578
-
Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil and leucovorin in patients with advanced solid tumors
-
Saltz, L. B., Kanowitz, J., Kemeny, N. E., Schaaf, L., Spriggs, D., Staton, B. A., Berkery, R., Steger, C., Eng, M., Dietz, A., Locker, P., and Kelsen, D. P. Phase I clinical and pharmacokinetic study of irinotecan, fluorouracil and leucovorin in patients with advanced solid tumors. J. Clin. Oncol., 14: 2959-2967, 1996.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 2959-2967
-
-
Saltz, L.B.1
Kanowitz, J.2
Kemeny, N.E.3
Schaaf, L.4
Spriggs, D.5
Staton, B.A.6
Berkery, R.7
Steger, C.8
Eng, M.9
Dietz, A.10
Locker, P.11
Kelsen, D.P.12
-
13
-
-
9844257984
-
Phase I trial of sequential Tomudex (TOM) and 5-fluorouracil (5FU) in patients with advanced colorectal carcinoma
-
Schwartz, G. K., Kemeny, N., Saltz, L., Sugarman, A., Danso, D., Kelsen, D. K., Tong, W., and Bertino, J. Phase I trial of sequential Tomudex (TOM) and 5-fluorouracil (5FU) in patients with advanced colorectal carcinoma. Proc. Am. Soc. Clin. Oncol., 16: 728, 1997.
-
(1997)
Proc. Am. Soc. Clin. Oncol.
, vol.16
, pp. 728
-
-
Schwartz, G.K.1
Kemeny, N.2
Saltz, L.3
Sugarman, A.4
Danso, D.5
Kelsen, D.K.6
Tong, W.7
Bertino, J.8
-
14
-
-
0025272187
-
Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse
-
Kaneda, N., Hiroshi, N., Furuta, T., and Yokokura, T. Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse. Cancer Res., 50: 1715-1720, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 1715-1720
-
-
Kaneda, N.1
Hiroshi, N.2
Furuta, T.3
Yokokura, T.4
-
16
-
-
0021118703
-
Quantitative analysis of dose-effect relationship: The combined effects of multiple drugs or enzyme inhibitors
-
Chou, T. C., and Talalay, P. Quantitative analysis of dose-effect relationship: the combined effects of multiple drugs or enzyme inhibitors. Adv. Enzyme Regul., 22: 27-55, 1984.
-
(1984)
Adv. Enzyme Regul.
, vol.22
, pp. 27-55
-
-
Chou, T.C.1
Talalay, P.2
-
17
-
-
0002658306
-
The median-effect principle and the combination index for quantitation of synergism and antagonism
-
T. C. Chou and D. Rideout (eds.), New York: Academic Press
-
Chou, T. C. The median-effect principle and the combination index for quantitation of synergism and antagonism. In: T. C. Chou and D. Rideout (eds.), Synergism and Antagonism in Chemotherapy, pp. 61-102. New York: Academic Press, 1991.
-
(1991)
Synergism and Antagonism in Chemotherapy
, pp. 61-102
-
-
Chou, T.C.1
-
18
-
-
0000216613
-
Chemotherapeutic synergism, potentiation and antagonism
-
R. Dulbecco (ed.), New York: Academic Press
-
Chou, T. C., Rideout, D., and Chou, J. Chemotherapeutic synergism, potentiation and antagonism. In: R. Dulbecco (ed.), Encyclopedia of Human Biology, Vol. 2, pp. 371-379. New York: Academic Press, 1991.
-
(1991)
Encyclopedia of Human Biology
, vol.2
, pp. 371-379
-
-
Chou, T.C.1
Rideout, D.2
Chou, J.3
-
19
-
-
0021825349
-
Sequence-dependent synergism between dicloromethotrexate and cisplatin in a human colon carcinoma cell line
-
Sobrero, A. F., and Bertino, J. R. Sequence-dependent synergism between dicloromethotrexate and cisplatin in a human colon carcinoma cell line. Cancer Treat. Rep., 69: 279-283, 1985.
-
(1985)
Cancer Treat. Rep.
, vol.69
, pp. 279-283
-
-
Sobrero, A.F.1
Bertino, J.R.2
-
20
-
-
0027358510
-
Synergism and lack of cross-resistance between short-term and continuous exposure to fluorouracil in human colon adenocarcinoma cells
-
Sobrero, A. F., Aschele, C., Guglielmi, A. P., Mori, A. M., Melioli, G. G., Rosso, R., and Bertino, J. R. Synergism and lack of cross-resistance between short-term and continuous exposure to fluorouracil in human colon adenocarcinoma cells. J. Natl. Cancer Inst., 85: 1937-1944, 1993.
-
(1993)
J. Natl. Cancer Inst.
, vol.85
, pp. 1937-1944
-
-
Sobrero, A.F.1
Aschele, C.2
Guglielmi, A.P.3
Mori, A.M.4
Melioli, G.G.5
Rosso, R.6
Bertino, J.R.7
-
21
-
-
0031015454
-
Fluorouracil in colorectal cancer-a tale of two drugs: Implications for biochemical modulation
-
Sobrero, A. F., Aschele, C., and Bertino, J. R. Fluorouracil in colorectal cancer-a tale of two drugs: implications for biochemical modulation. J. Clin. Oncol., 15: 368-381, 1997.
-
(1997)
J. Clin. Oncol.
, vol.15
, pp. 368-381
-
-
Sobrero, A.F.1
Aschele, C.2
Bertino, J.R.3
-
22
-
-
0029128603
-
5-Fluorouracil prodrugs: Role of anabolic and catabolic pathway modulation in therapy of colorectal cancer
-
Cao, S., Frank, C., Shirasaka, T., and Rustum, Y. 5-Fluorouracil prodrugs: role of anabolic and catabolic pathway modulation in therapy of colorectal cancer. Clin. Cancer Res., 1: 839-845, 1995.
-
(1995)
Clin. Cancer Res.
, vol.1
, pp. 839-845
-
-
Cao, S.1
Frank, C.2
Shirasaka, T.3
Rustum, Y.4
-
23
-
-
9344248389
-
Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyrimidine-1 M potassium oxonate (S-1) against human cancer carcinoma orthotopically implanted into nude rats
-
Shirasaka, T., Nakano, K., Takechi, T., Satake, H., Ukida, J., Fujioka, A., Saito, H., Okabe, H., Oyama, K., Takeda, S., Unemi, N., and Fukushima, M. Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypyrimidine-1 M potassium oxonate (S-1) against human cancer carcinoma orthotopically implanted into nude rats. Cancer Res., 56: 2602-2606, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 2602-2606
-
-
Shirasaka, T.1
Nakano, K.2
Takechi, T.3
Satake, H.4
Ukida, J.5
Fujioka, A.6
Saito, H.7
Okabe, H.8
Oyama, K.9
Takeda, S.10
Unemi, N.11
Fukushima, M.12
-
24
-
-
0023597504
-
Mechanism of action of 5,8-dideazaisofolic acid and other quinazoline antifols in human colon carcinoma cells
-
McGuire, J. J., Sobrero, A., Hynes, J. B., and Bertino, J. R. Mechanism of action of 5,8-dideazaisofolic acid and other quinazoline antifols in human colon carcinoma cells. Cancer Res., 47: 5975-5981, 1987.
-
(1987)
Cancer Res.
, vol.47
, pp. 5975-5981
-
-
McGuire, J.J.1
Sobrero, A.2
Hynes, J.B.3
Bertino, J.R.4
-
25
-
-
0031014682
-
Thymidylate synthase inhibitors in cancer therapy: Direct and indirect inhibitors
-
Rustum, Y. M., Harstrick, A., Cao, S., Vanhoefer, U., Yin, M. B., Wilke, H., and Seeber, S. Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors. J. Clin. Oncol., 15: 389-400, 1997.
-
(1997)
J. Clin. Oncol.
, vol.15
, pp. 389-400
-
-
Rustum, Y.M.1
Harstrick, A.2
Cao, S.3
Vanhoefer, U.4
Yin, M.B.5
Wilke, H.6
Seeber, S.7
-
26
-
-
0029960812
-
Eukaryotic DNA topoisomerase I: Genome gatekeeper and its intruders, camptothecins
-
Pommier, Y. Eukaryotic DNA topoisomerase I: genome gatekeeper and its intruders, camptothecins. Semin. Oncol., 23 (Suppl. 3): 3-10, 1996.
-
(1996)
Semin. Oncol.
, vol.23
, Issue.3 SUPPL.
, pp. 3-10
-
-
Pommier, Y.1
-
27
-
-
0028340348
-
Simultaneous administration of CPT-11 and 5-fluorouracil: Alteration of the pharmacokinetics of CPT-11 and SN-38 in patients with advanced colorectal cancer
-
Sasaki, Y., Ohtsu, A., Shimada, Y., Ono, K., and Saijo, N. Simultaneous administration of CPT-11 and 5-fluorouracil: alteration of the pharmacokinetics of CPT-11 and SN-38 in patients with advanced colorectal cancer. J. Natl. Cancer Inst. 86: 1096-1098, 1994.
-
(1994)
J. Natl. Cancer Inst.
, vol.86
, pp. 1096-1098
-
-
Sasaki, Y.1
Ohtsu, A.2
Shimada, Y.3
Ono, K.4
Saijo, N.5
-
28
-
-
15144356523
-
Biochemical and pharmacological principles of combination chemotherapy
-
Sartorelli, A. C. Biochemical and pharmacological principles of combination chemotherapy. Biochem. Pharmacol., 23 (Suppl. 2): 129, 1974.
-
(1974)
Biochem. Pharmacol.
, vol.23
, Issue.2 SUPPL.
, pp. 129
-
-
Sartorelli, A.C.1
-
29
-
-
0030248494
-
The clinical status of irinotecan (CPT-11), a novel water soluble camptothecin analogue: 1996
-
O'Reilly, S., and Rowinsky, E. C. The clinical status of irinotecan (CPT-11), a novel water soluble camptothecin analogue: 1996. Crit. Rev. Oncol. Hematol., 24: 47-70, 1996.
-
(1996)
Crit. Rev. Oncol. Hematol.
, vol.24
, pp. 47-70
-
-
O'Reilly, S.1
Rowinsky, E.C.2
-
30
-
-
0025744809
-
The pharmacokinetics of the quinazoline antifolate ICI DI 1694 in mice and rats
-
Jodrell, D. I., Newell, D. R., Gibson, W., Hughes, L. R., and Calvert, A. H. The pharmacokinetics of the quinazoline antifolate ICI DI 1694 in mice and rats. Cancer Chemother. Pharmacol., 28: 331-338, 1991.
-
(1991)
Cancer Chemother. Pharmacol.
, vol.28
, pp. 331-338
-
-
Jodrell, D.I.1
Newell, D.R.2
Gibson, W.3
Hughes, L.R.4
Calvert, A.H.5
-
31
-
-
0030856521
-
Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in Phase I/II trials
-
Rivory, L. P., Haaz, M., Canal, P., Lokiec, F., Armand, J., and Robert, J. Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in Phase I/II trials. Clin. Cancer Res., 3: 1261-1266, 1997.
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 1261-1266
-
-
Rivory, L.P.1
Haaz, M.2
Canal, P.3
Lokiec, F.4
Armand, J.5
Robert, J.6
-
32
-
-
0028854897
-
Phase I trial and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients
-
Abigerges, D., Chabot, G. G., Armand, J., Hérait, P., Gouyette, A., and Gandia, D. Phase I trial and pharmacologic studies of the camptothecin analog irinotecan administered every 3 weeks in cancer patients. J. Clin. Oncol., 13: 210-221, 1995.
-
(1995)
J. Clin. Oncol.
, vol.13
, pp. 210-221
-
-
Abigerges, D.1
Chabot, G.G.2
Armand, J.3
Hérait, P.4
Gouyette, A.5
Gandia, D.6
-
33
-
-
0025342506
-
Nonlinear pharmacokinetics of CPF-11 in rats
-
Kaneda, N., and Yokokura, T. Nonlinear pharmacokinetics of CPF-11 in rats. Cancer Res., 50; 1721-1725, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 1721-1725
-
-
Kaneda, N.1
Yokokura, T.2
-
34
-
-
9044245305
-
ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer
-
Zalcberg, J. R., Cunningham, D., and Van Cutsem, E. ZD1694: a novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. J. Clin. Oncol., 14: 716-721, 1996.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 716-721
-
-
Zalcberg, J.R.1
Cunningham, D.2
Van Cutsem, E.3
-
35
-
-
0028346901
-
Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea
-
Abigerges, D., Armand, J. P., Chabot, G. G., Da Costa, L., Fadel, E., and Cote, C. Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea. J. Natl. Cancer Inst., 86: 446-449, 1994.
-
(1994)
J. Natl. Cancer Inst.
, vol.86
, pp. 446-449
-
-
Abigerges, D.1
Armand, J.P.2
Chabot, G.G.3
Da Costa, L.4
Fadel, E.5
Cote, C.6
|