A cryptic insertion (17;15) on both chromosomes 17 with lack of PML-RARA expression in a case of atypical acute promyelocytic leukemia [12]

Leukemia

Volumn 18, Issue 1, 2004, Pages 183-186

  Tchinda, J ^a   Volpert, S ^a   Liersch, R ^a   Zuhlsdorf M ^a   Serve, H ^a   Neumann, T ^a   Kennerknecht, I ^a   Berdel, W E ^a   Buchner T ^a   Horst, J ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; DAUNORUBICIN; FIBRIN DEGRADATION PRODUCT; MITOXANTRONE; PROMYELOCYTIC LEUKEMIA PROTEIN; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; TIOGUANINE;

ADULT; BLOOD CELL COUNT; BLOOD CLOTTING TEST; BONE MARROW BIOPSY; CANCER COMBINATION CHEMOTHERAPY; CANCER RECURRENCE; CASE REPORT; CHROMOSOME 17; CHROMOSOME INSERTION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; HEMATOMA; HIGH RISK PATIENT; HUMAN; IMMUNOPHENOTYPING; KARYOTYPING; LETTER; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLENOMEGALY;

EID: 10744227771     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2403148     Document Type: Letter

References (8)

1. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee Meeting-Airlie House, Virginia, November 1997. J Clin Oncol 1999; 17: 3835-3849.
2. Grimwade D, Lo Coco F. Acute promyelocytic leukemia: a model for the role of molecular diagnosis and residual disease monitoring in directing treatment approach in acute myeloid leukemia. Leukemia 2002; 16: 1959-1973.
3. Burnett AK, Grimwade D, Solomon E, Wheatley K, Goldstone AH. Presenting white blood cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukemia treated with all-trans retinoic acid: result of the randomized MRC Trial. Blood 1999; 93: 4131-4143.
4. Hiorns LR, Min T, Swansbury GJ, Zelent A, Dyer MJ, Catovsky D. Interstitial insertion of retinoic acid receptor-α gene in acute promyelocytic leukemia with normal chromosomes 15 and 17. Blood 1994; 83: 2946-2951.
5. Grimwade D, Biondi A, Mozziconacci M-J, Hagemeijer A, Berger R, Neat M et al. Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Blood 2000; 96: 1297-1308.
6. Borrow J, Goddard AD, Gibbons B, Katz F, Swirsky D, Fioretos T et al. Diagnosis of acute promyelocytic leukaemia by RT-PCR: detection of PML-RARA and RARA-PML fusion transcripts. Br J Haematol 1992; 82: 529-540.
7. Lengfelder E, Reichert A, Schoch C, Haase D, Löffler H, Staib P et al. Double induction strategy including high dose cytarabine in combination with all-trans retinoic acid: effects in patients with newly diagnosed acute promyelocytic leukemia. Leukemia 2000; 14: 1362-1370.
8. Hagemeijer A, Buijs A, Smit E, Janssen B, Creemers GJ, Van der Plas D et al. Translocation of BCR to chromosome 9: a new cytogenetic variant detected by FISH in two Ph-negative, BCR-positive patients with chronic myeloid leukemia. Genes Chromosomes Cancer 1993; 8: 237-245.