Suppression of alcohol delirium tremens by baclofen administration: A case report

Clinical Neuropharmacology

Volumn 26, Issue 5, 2003, Pages 258-262

  Addolorato, Giovanni ^a   Leggio, Lorenzo ^a   Abenavoli, Ludovico ^a   DeLorenzi, Giosue ^a   Parente, Antonio ^a   Caputo, Fabio ^b   Janiri, Luigi ^a   Capristo, Esmeralda ^a   Rapaccini, Gian Ludovico ^a   Gasbarrini, Giovanni ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Baclofen; Delirium tremens; GABAB receptor agonist

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; BACLOFEN; BENZODIAZEPINE DERIVATIVE;

ADULT; ALCOHOL WITHDRAWAL; ARTICLE; CASE REPORT; DELIRIUM TREMENS; DISEASE SEVERITY; DRUG EFFICACY; HUMAN; MALE; MORBIDITY; MORTALITY; PRIORITY JOURNAL; SIDE EFFECT; STEREOCHEMISTRY; TREATMENT OUTCOME;

ADULT; ALCOHOL WITHDRAWAL DELIRIUM; BACLOFEN; GABA AGONISTS; HUMANS; MALE;

EID: 10744227722     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002826-200309000-00010     Document Type: Article

References (22)

1. Fiellin DA, O'Connor PG, Holmboe ES, Horwitz RI. Risk for Delirium Tremens in Patients with Alcohol withdrawal syndrome. J Subst Abuse. 2002;23:83-94.
2. Hersh D, Kranzler HR, Meyer RE. Persistent Delirium following cessation of heavy alcohol consumption: diagnostic and treatment implications. Am J Psychiatry. 1997;154:846-851.
3. Erwin WE, Williams DB, Speir WA. Delirium tremens. South Med J. 1998;91:425-432.
4. Victor M, Adams RD. The effect of alcohol on the central nervous system. Res Publ Assoc Nerv Ment Dis. 1953;32:526-623.
5. Cushman P Jr. Delirium tremens: update on an old disorder. Postgrad Med. 1987;82:117-122.
6. Guthrie SK. The treatment of alcohol withdrawal. Pharmacotherapy. 1989;9:131-143.
7. Davidoff RA. Antispasticity drugs: mechanisms of action. Ann Neurol. 1985;17:107-116.
8. Colombo G, Agabio R, Carai MAM, et al. Ability of baclofen in reducing alcohol intake and withdrawal severity: I. preclinical evidence. Alcohol Clin Exp Res. 2000;1:58-66.
9. Addolorato G, Caputo F, Capristo E, et al. Rapid suppression of alcohol withdrawal syndrome by baclofen. Am J Med. 2002;112: 226-229.
10. Addolorato G, Caputo F, Capristo E, et al. Ability of Baclofen in reducing alcohol craving and intake: II. preliminary clinical evidence. Alcohol Clin Exp Res. 2000;1:67-71.
11. Addolorato G, Caputo F, Capristo E, et al. Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomized controlled study. Alcohol Alcohol. 2002;37:504-508.
12. Sullivan JT, Sykora K, Schneiderman J, et al. Assessment of alcohol withdrawal: the revised Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-Ar). Br J Addict. 1989;84:1353-1357.
13. Holbrook AH, Crowther R, Cheng C. Diagnosis and management of acute alcohol withdrawal. Can Med Assoc J. 1999;160:675-680.
14. Lejoyeux M, Solomon J, Adès J. Benzodiazepine treatment for alcohol-dependent patients. Alcohol Alcohol. 1998;33:563-575.
15. Chick J. Delirium Tremens. Try to spot it early. BMJ. 1989;298:3-4.
16. Hall W, Zador D. The alcohol withdrawal syndrome. Lancet. 1997; 349:1897-1900.
17. Turner RC, Lichstein PR, Peden JG, et al. Alcohol withdrawal syndromes. J Gen Intern Med. 1989;4:432-434.
18. Hoey LL, Nahum A, Vance-Bryan K. A prospective evaluation of benzodiazepine guidelines in the management of patient hospitalized for alcohol withdrawal. Pharmacotherapy. 1994;14:579-585.
19. Mayo-Smith MF. Pharmacological management of alcohol withdrawal. A meta-analysis and evidence-based practice guideline. JAMA. 1997;278:144-151.
20. Ross HE. Benzodiazepine use and anxiolytic abuse and dependence in treated alcoholics. Addiction. 1993;88:209-218.
21. Misgeld U, Bijak M, Jarolimek W. A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system. Prog Neurobiol. 1995;46:423-462.
22. Hoffman PL, Grant KA, Snell LD, et al. NMDA receptors: role in ethanol withdrawal seizures. Ann NY Acad Sci. 1992;654:52-60.