Associations among oxidized low-density lipoprotein antibody, C-reactive protein, interleukin-6, and circulating cell adhesion molecules in patients with unstable angina pectoris

American Journal of Cardiology

Volumn 93, Issue 5, 2004, Pages 554-558

  Doo, Young Cheoul ^a   Han, Sang Jin ^a   Lee, Jun Hee ^a   Cho, Goo Yung ^a   Hong, Kyung Soon ^a   Han, Kyoo Rok ^a   Lee, Nam Ho ^a   Oh, Dong Jin ^a   Ryu, Kyu Hyung ^a   Rhim, Chong Yun ^a   Lee, Kwang Hwahk ^a   Lee, Yung ^a  

^a Hallym University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; CELL ADHESION MOLECULE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MARKER; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN ANTIBODY; STATIN;

ADULT; AGE; AGED; ANTIBODY TITER; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR RISK; CIRCULATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DRUG USE; FEMALE; GENDER; HOSPITAL ADMISSION; HUMAN; INFLAMMATION; KAPLAN MEIER METHOD; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PATIENT; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SURVIVAL RATE; UNSTABLE ANGINA PECTORIS;

AGED; ANGINA, UNSTABLE; ANTIBODIES; C-REACTIVE PROTEIN; CELL ADHESION MOLECULES; FEMALE; HUMANS; INTERLEUKIN-6; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SURVIVAL RATE;

EID: 10744227686     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2003.11.017     Document Type: Article

References (29)

1. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med. 340:1999;115-126.
2. Havekate F., Thompson S.G., Pyke S.D., Gallimore J.R., European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Production of C-reactive protein and risk of coronary events in stable and unstable angina. Lancet. 349:1997;462-466.
3. Ridker P.M., Cushman M., Stampfer M.J., Tracy R.P., Hennekens C.H. Inflammation, aspirin and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 336:1997;973-979.
4. Witztum J.L., Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest. 73:1991;155-167.
5. Reaven P.D. Mechanism of atherosclerosis role of LDL oxidation. Free Radic Diagn Med. 366:1994;113-128.
6. Hansson G.K. Cell-mediated immunity in atherosclerosis. Curr Opin Lipidol. 8:1997;301-311.
7. Palinski W., Rosenfeld M.E., Yla-Herttuala S., Gurtner G.C., Socher S.S., Butler S.W., Parthasarathy S., Carew T.E., Steinberg D., Witztum J.L. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci USA. 86:1989;1372-1376.
8. Parumus D.V., Brown D.L., Mitchison M.J. Serum antibodies to oxidized low density lipoprotein and carotid in chronic periaortitis. Arch Pathol Lab Med. 114:1990;383-387.
9. Yla-Herttuala S., Palinski W., Butler S.W., Picard S., Steinberg D., Witztum J.L. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL. Arterioscler Thromb. 14:1994;32-40.
10. Rosenfeld M.E., Palinski W., Yla-Herttuala S., Butler S.W., Witztum J.L. Distribution of oxidation specific lipid protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits. Atherosclerosis. 10:1990;336-349.
11. Maggi E., Finardi G., Poli M., Bollati P., Filipponi M., Stefano P.L., Paolini G., Grossi A., Clot P., Albano E., Bellomo G. Specificity to autoantibodies against oxidized LDL as an additional marker for atherosclerotic risk. Coron Artery Dis. 4:1993;1119-1122.
12. Lehtimaki T., Lehtinen S., Solakivi T., Nikkila M., Jaakkola O., Jokela H., Yla-Herttuala S., Luoma J.S., Koivula T., Nikkare T. Autoantibodies against oxidized low density lipoprotein in patients with angiographically verified coronary artery disease. Arterioscler Thromb Vasc Biol. 19:1999;23-27.
13. Uusitupa M., Niskanen L., Luoma J., Vilja P., Mercuri M., Rauramaa R., Yla-Herttuala S. Autoantibodies against oxidized LDL do not predict atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus. Arterioscler Thromb Vasc Biol. 16:1996;1236-1242.
14. Van de Vijer L., Steyger R., Poppel G., Boer J., Kruijssen D., Seidell J., Princen H. Autoantibodies against MDA-LDL in subjects with severe and minor atherosclerosis and healthy population controls. Atherosclerosis. 122:1996;245-253.
15. Cybulsky M.I., Gimbrone M.A. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 251:1991;788-790.
16. Sakai A., Kume N., Nishi E., Tanoue K., Miyasaka M., Kita T. P-selectin and vascular cell adhesion molecule-1 are focally expressed in aortas of hypercholesterolemic rabbits before intimal accumulation of macrophages and T-lymphocytes. Arterioscler Thromb Vasc Biol. 17:1997;310-316.
17. Davies M.J., Gordon J.L., Gearing A.J., Pigott R., Woolf N., Katz D., Kyriakopoulos A. The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J Pathol. 171:1993;223-229.
18. Ridker P.M., Hennekens C.H., Roitman-Johnson B., Stamper M.J., Allen J. Plasma concentration of soluble intercellular adhesion molecule-1 and risks of future myocardial infarction in apparently healthy men. Lancet. 351:1998;88-92.
19. Hwang S.J., Ballantyne C.M., Sharrett A.R., Smith L.C., Davies C.E., Gotto A.M. Jr, Boerwinkle E. Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases the Atherosclerosis Risk In Communities (ARIC) study. Circulation. 86:1997;4219-4225.
20. Takei A., Huang Y., Lopes-Virella M.F. Expression of adhesion molecules by human endothelial cells exposed to oxidized low density lipoprotein. Influences of degree of oxidation and location of oxidized LDL. Atherosclerosis. 154:2001;79-86.
21. O'byrne D., Devaraj S., Islam K.N., Collazo R., MacDonal L., Grundy S., Jiala I. Low-density lipoprotein induced monocyte-endothelial cell adhesion, soluble cell adhesion molecules, and autoantibodies to oxidized-LDL in chronic renal failure patients on dialysis therapy. Metabolism. 50:2001;207-215.
22. Shih P.T., Elices M.J., Fang Z.T., Ugarova T.P., Strahl D., Territo M.C., Frank J.S., Kovach N.L., Cabanas C., Berliner J.A., Vora D.K. Minimally modified low-density lipoprotein induced monocyte adhesion to endothelial connecting segment-1 by activating beta 1 integrin. J Clin Invest. 103:1999;613-625.
23. Ameli S., Hultgardh-Nilsson A., Regnstrom J., Calara F., Yano J., Cercek B., Shah P.K., Nilsson J. Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits. Arterioscler Thromb Vasc Biol. 16:1996;1074-1079.
24. Nilsson J., Calara F., Regnstrom J., Hultgardh-Nilsson A., Ameli S., Cercek B., Shah P.K. Immunization with homologous oxidized low density lipoprotein reduces neointimal formation after balloon injury in hypercholesterolemic rabbits. J Am Coll Cardiol. 30:1997;1886-1891.
25. Shoji T., Nishizawa Y., Fukumoto M., Shimamura K., Kimura J., Kands H., Emoto M., Kawagishi T., Morii H. Inverse relationship between circulating oxidized low density lipoprotein (oxLDL) and anti-oxLDL antibody levels in healthy subjects. Atherosclerosis. 148:2000;171-177.
26. Lopes-Virella M.F., Virella G., Orchard T.J., Koskinen S., Evans R.W., Becker D.J., Forrest K. Antibodies to oxidized LDL and LDL-containing immune complexes as risk factors for coronary artery disease in diabetes mellitus. Clin Immunol. 90:1999;165-172.
27. Hansson G.K. Cell-mediated immunity in atherosclerosis. Curr Opin Lipidol. 131:(suppl):1997;S9-S11.
28. Pigott R., Dillon L.P., Hemingway I.H., Gearing A.J. Soluble forms of E-selectin, ICAM-1, and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells. Biochem Biophys Res Commun. 187:1992;584-589.
29. Nakashima Y., Raines E.W., Plump A.S., Breslow J.L., Ross R. Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the apo E-deficient mouse. Arterioscler Thromb Vasc Biol. 18:1998;842-851.