CSF hypocretin measures in patients with obstructive sleep apnea

Journal of Sleep Research

Volumn 12, Issue 4, 2003, Pages 339-341

  Kanbayashi, T ^a   Inoue, Y ^b   Kawanishi, K ^c   Takasaki, H ^d   Aizawa, R ^a   Takahashi, K ^a   Ogawa, Y ^a   Abe, M ^a   Hishikawa, Y ^a   Shimizu, T ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Kansai Denryoku Hospital   (Japan)

^d ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Cerebrospinal fluid; Hypocretin; Narcolepsy; Obstructive sleep apnea; Orexin

Indexed keywords

OREXIN A;

ADULT; AGED; ARTICLE; CATAPLEXY; CEREBROSPINAL FLUID EXAMINATION; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; HUMAN; LATENT PERIOD; MALE; NARCOLEPSY; PRIORITY JOURNAL; REM SLEEP; SLEEP APNEA SYNDROME; SLEEP DISORDER;

EID: 10744226483     PISSN: 09621105     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0962-1105.2003.00373.x     Document Type: Article

References (12)

1. Browman, C. P., Gujavarty, K. S., Sampson, M. G. and Mitler, M. M. REM sleep episodes during the maintenance of wakefulness test in patients with sleep apnea syndrome and patients with narcolepsy. Sleep, 1983, 6: 23-28.
2. Browman, C. P., Sampson, M. G., Yolles, S. F., Gujavarty, K. S., Weiler, S. J., Walsleben, J. A., Hahn, P. M. and Mitler, M. M. Obstructive sleep apnea and body weight. Chest, 1984, 85: 435-438.
3. Dalal, M. A., Schuld, A., Haack, M., Uhr, M., Geisler, P., Eisensehr, I., Noachtar, S. and Pollmacher, T. Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients. Neurology, 2001, 56: 1749-1751.
4. Ebrahim, I. O., Howard, R. S., Kopelman, M. D., Sharief, M. K. and Williams, A. J. The hypocretin/orexin system. J. R. Soc. Med., 2002, 95: 227-230.
5. Kanbayashi, T., Inoue, Y., Chiba, S., Aizawa, R., Saito, Y., Tsukamoto, H., Fujii, Y., Nishino, S. and Shimizu, T. CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia. J. Sleep Res., 2002, 11: 91-93.
6. Mignot, E., Lammers, G. J., Ripley, B., Okun, M., Nevsimalova, S., Overeem, S., Vankova, J., Black, J., Harsh, J., Bassetti, C., Schrader, H. and Nishino, S. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch. Neurol., 2002, 59: 1553-1562.
7. Nishino, S., Ripley, B., Overeem, S., Nevsimalova, S., Lammers, G. J., Vankova, J., Okun, M., Rogers, W., Brooks, S. and Mignot, E. Low CSF hypocretin (orexin) and altered energy homeostasis in human narcolepsy. Annal. Neurol., 2001, 50: 381-388.
8. van den Pol, A. N. Hypothalamic hypocretin (orexin): robust innervation of the spinal cord. J. Neurosci., 1999, 19: 3171-3182.
9. Ripley, B., Overeem, S., Fujiki, N., Nevsimalova, S., Uchino, M., Yesavage, J., Di Monte, D., Dohi, K., Melberg, A., Lammers, G. J., Nishida, Y., Roelandse, F. W., Hungs, M., Mignot, E. and Nishino, S. CSF hypocretin/orexin levels in narcolepsy and other neurological conditions. Neurology, 2001, 57: 2253-2258.
10. Shimizu, T., Takahashi, Y., Kogawa, S., Takahashi, K., Kanbayashi, T., Saito, Y. and Hishikawa, Y. Muscle sympathetic nerve activity during apneic episodes in patients with obstructive sleep apnea syndrome. Electroencephalogr. Clin. Neurophysiol., 1994, 93: 345-352.
11. Yoshida, Y., Fujiki, N., Nakajima, T., Ripley, B., Matsumura, H., Yoneda, H., Mignot, E. and Nishino, S. Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities. Eur. J. Neurosci., 2001, 14: 1075-1081.
12. Young, T., Palta, M., Dempsey, J., Skatrud, J., Weber, S. and Badr, S. The occurrence of sleep-disordered breathing among middle-aged adults. N. Engl. J. Med., 1993, 328: 1230-1235.