Polymorphisms in the tumour necrosis factor gene are not associated with severity of inflammatory polyarthritis

Annals of the Rheumatic Diseases

Volumn 63, Issue 3, 2004, Pages 280-284

  Barton, A ^a   Platt, H ^a   Salway, F ^a   Symmons, D ^a   Barrett, E ^a   Bukhari, M ^a   Lunt, M ^a   Zeggini, E ^a   Eyre, S ^a   Hinks, A ^a   Tellam, D ^a   Brintnell, B ^a   Ollier, W ^a   Worthington, J ^a   Silman, A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; ASSAY; BONE EROSION; DISEASE SEVERITY; FEMALE; GENE MAPPING; GENOTYPE; HAPLOTYPE; HUMAN; MALE; POLYARTHRITIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ARTHRITIS; ARTHROGRAPHY; CHI-SQUARE DISTRIBUTION; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RHEUMATOID FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 10744226097     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2003.008680     Document Type: Article

References (45)

1. Symmons D, Turner G, Webb R, Asten P, Barrett E, Lunt M, et al. The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century. Rheumatology (Oxford) 2002;41:793-800.
2. MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, et al. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 2000;43:30-7.
3. Deighton CM, Walker DJ, Griffiths ID, Roberts DF. The contribution of HLA to rheumatoid arthritis. Clin Genet 1989;36:178-82.
4. Ota M, Katsuyama Y, Kimura A, Tsuchiya K, Kondo M, Naruse T, et al. A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localised within a 70Kb interval telomeric of the TNF genes in the HLA class III region. Genomics 2001;71:263-70.
5. Zanelli E, Jones G, Pascual M, Eerligh P, van der Silk AR, Zwinderman AH, et al. The telomeric part of the HLA region predisposes to rheumatoid arthritis independently of the class II loci. Hum Immunol 2001;62:75-84.
6. Jawaheer D, Li W, Graham RR, Chen W, Damle A, Xiao X, et al. Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis. Am J Hum Genet 2002;71:585-94.
7. Feldmann M, Brennan FM, Moini RN. Cytokines in rheumatoid arthritis. Ann Rev Immunol 1996;14:397-440.
8. Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 1991;10:4025-31.
9. Bondeson J, Maini RN. Tumour necrosis factor as a therapeutic target in rheumatoid arthritis and other chronic inflammatory diseases: the clinical experience with infliximab (REMICADE). Int J Clin Pract 2001;55:211-16.
10. Zeggini E, Thomson W, Kwiatkowski D, Richardson A, Ollier W, the BPRG Study Group, et al. Linkage and association studies of single nucleotide polymorphism-tagged tumour necrosis factor haplotypes in juvenile oligoarthritis. Arthritis Rheum 2002;46:3304-11.
11. van Krugten MV, Huizinga TW, Kaijzel EL, Zanelli E, Drossaers-Bakker KW, van de LP, et al. Association of the TNF +489 polymorphism with susceptibility and radiographic damage in rheumatoid arthritis. Genes Immun 1999;1:91-6.
12. Waldron-Lynch F, Adams C, Amos C, Zhu DK, McDermott MF, Shanahan F, et al. Tumour necrosis factor 5′ promoter single nucleotide polymorphisms influence susceptibility to rheumatoid arthritis (RA) in immunogenetically defined multiplex RA families. Genes Immun 2001;2:82-7.
13. Seki N, Kamizono S, Yamada A, Higuchi T, Matsumoto H, Niiya F, et al. Polymorphisms in the 5′-flanking region of tumor necrosis factor-alpha gene in patients with rheumatoid arthritis. Tissue Antigens 1999;54:194-7.
14. Vinasco J, Beraun Y, Nieto A, Fraile A, Mataran L, Pareja E, et al. Polymorphism at the TNF loci in rheumatoid arthritis. Tissue Antigens 1997;49:74-8.
15. Yen JH, Chen CJ, Tsai WC, Lin CH, Ou TT, Wu CC, et al. Tumor necrosis factor promoter polymorphisms in patients with rheumatoid arthritis in Taiwan. J Rheumatol 2001;28:1788-92.
16. Brinkman BM, Huizinga TW, Kurban SS, van der Velde EA, Schreuder GM, Hazes JM, et al. Tumour necrosis factor alpha gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease? Br J Rheumatol 1997;36:516-21.
17. Lacki JK, Moser R, Korczowska I, Mackiewicz S, Muller W. TNF-alpha gene polymorphism does not affect the clinical and radiological outcome of rheumatoid arthritis. Rheumatol Int 2000;19:137-40.
18. Field M, Gallagher G, Eskdale J, McGarry F, Richards SD, Munro R, et al. Tumor necrosis factor locus polymorphisms in rheumatoid arthritis. Tissue Antigens 1997;50:303-7.
19. Low AS, Gonzalez-Goy MA, Akil M, Amos RS, Bax DE, Cannings C, et al. TNF +489 polymorphism does not contribute to susceptibility to rheumatoid arthritis. Clin Exp Rheumatol 2002;20:829-32.
20. Symmons DP, Barrett EM, Bonkhead CR, Scott DG, Silman AJ. The incidence of rheumatoid arthritis in the United Kingdom: results from the Norfolk Arthritis Register. Br J Rheumatol 1994;33:735-9.
21. Dugowson CE, Nelson JL, Koepsell TD. Evaluation of the 1987 revised criteria for rheumatoid arthritis in a cohort of newly diagnosed female patients. Arthritis Rheum 1990;33:1042-6.
22. Sharp JT. Radiologic assessment as an outcome measure in rheumatoid arthritis. Arthritis Rheum 1989;32:221-9.
23. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
24. MacGregor AJ, Bamder S, Silman AJ. A comparison of the performance of different methods of disease classification for rheumatoid arthritis. Results from an analysis from a nationwide twin study. J Rheumatol 1994;21:1420-6.
25. Bukhari M, Harrison B, Lunt M, Scott DG, Symmons DP, Silman AJ. Time to first occurrence of erosions in inflammatory polyarthritis: results from a prospective community-based study. Arthritis Rheum 2001;44:1248-53.
26. Dale K. Radiographic damage assessment: the method and technique. Rheumatology in Europe 2002;23:136-41.
27. Sham PC, Curtis D. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci. Ann Hum Genet 1995;59(Pt 1):97-105.
28. Wiles N, Symmons DP, Harrison B, Barrett E, Barrett JH, Scott DG, et al. Estimating the incidence of rheumatoid arthritis: trying to hit a moving target? Arthritis Rheum 1999;42:1339-46.
29. Symmons D, Hazes JM, Silman A. Cases of early inflammatory polyarthritis should not be classified as having rheumatoid arthritis. J Rheumatol 2003;30:902-4.
30. Bukhari MA, Wiles NJ, Lunt M, Harrison BJ, Scott DG, Symmons DP, et al. Influence of disease-modifying therapy on radiographic outcome in inflammatory polyarthritis at five years: results from a large observational inception study. Arthritis Rheum 2003;48:46-53.
31. van der Heijde DM. Joint erosions and patients with early rheumatoid arthritis. Br J Rheumatol 1995;34(suppl 2):74-8.
32. Mulcahy B, Waldron-Lynch F, McDermott MF, Adams C, Amos CI, Zhu DK, et al. Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis. Am J Hum Genet 1996;59:676-83.
33. Verweij CL. Tumour necrosis factor gene polymorphisms as severity markers in rheumatoid arthritis. Ann Rheum Dis 1999;58(suppl 1):i20-6.
34. Cvetkovic JT, Wallberg-Jonsson S, Stegmayr B, Rantopoa-Dahlqvist S, Lefvert AK. Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-alpha, IL-1beta, and IL-1Ra genes. J Rheumatol 2002;29:212-19.
35. Braun N, Michel U, Ernst BP, Metzner R, Bitsch A, Weber F, et al. Gene polymorphism at position -308 of the tumor-necrosis-factor-alpha (TNF-alpha) in multiple sclerosis and its influence on the regulation of TNF-alpha production. Neurosci Lett 1996;215:75-8.
36. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA 1997;94:3195-9.
37. Kroeger KM, Carville KS, Abraham U. The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription. Mol Immunol 1997;34:391-9.
38. Brinkman BM, Huizinga TW, Breedveld FC, Verweij CL. Allele-specific quantification of TNFA transcripts in rheumatoid arthritis. Hum Genet 1996;97:813-18.
39. Stuber F, Petersen M, Bakelmann F, Schade U. A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis. Crit Care Med 1996;24:381-4.
40. Pociot F, Briant L, Jongeneel CV, Molvig J, Worsaae H, Abbal M, et al. Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: a possible link to insulin- dependent diabetes mellitus. Eur J Immunol 1993;23:224-31.
41. Uglialoro AM, Turbay D, Pesavento PA, Delgado JC, McKenzie FE, Gribben JG, et al. Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-alpha gene promoter. Tissue Antigens 1998;52:359-67.
42. Kaijzel EL, van Krugten MV, Brinkman BM, Huizinga TW, van der Straaten T, Hazes JM, et al. Functional analysis of a human tumor necrosis factor alpha (TNF-alpha) promoter polymorphism related to joint damage in rheumatoid arthritis. Mol Med 1998;4:724-33.
43. Fabris M, Di PE, D'Elia A, Damante G, Sinigaglia L, Ferraccioli G. Tumor necrosis factor-alpha gene polymorphism in severe and mild- moderate rheumatoid arthritis. J Rheumatol 2002;29:29-33.
44. Kaijzel EL, Bayley JP, van Krugten MV, Smith L, van de Linde P, Bakker AM, et al. Allele-specific quantification of tumor necrosis factor alpha (TNF) transcription and the role of promoter polymorphisms in rheumatoid arthritis patients and healthy individuals. Genes Immun 2001;2:135-44.
45. Terry CF, Loukaci V, Green FR. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem 2000;275:18138-44.