Clinical, biochemical and therapeutical aspects of amiodarone-induced hypothyroidism (AIH) in geriatric patients with cardiac arrhythmias

Archives of Gerontology and Geriatrics

Volumn 38, Issue 1, 2004, Pages 27-36

  Gheri, R G ^a   Pucci, P ^a   Falsetti, C ^a   Luisi, M L E ^a   Cerisano, G P ^b   Gheri, C F ^a   Petruzzi, I ^a   Pinzani, P ^a   Salvadori, B ^a   Petruzzi, E ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

Amiodarone; Elderly subjects; Hypothyroidism

Indexed keywords

AMIODARONE; LIOTHYRONINE; THYROGLOBULIN; THYROTROPIN; THYROXINE;

AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; EVALUATION; FEMALE; FOLLOW UP; HEART ARRHYTHMIA; HUMAN; HYPOTHYROIDISM; ITALY; LABORATORY TEST; LIOTHYRONINE BLOOD LEVEL; MALE; PRIORITY JOURNAL; THYROXINE BLOOD LEVEL;

EID: 10744225615     PISSN: 01674943     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4943(03)00080-3     Document Type: Article

References (47)

1. Allen E.M., Appel M.C., Braverman L.E. The effect of iodide ingestion on the development of spontaneous lymphocytic thyroiditis in the diabetes-prone BB/W rat. Endocrinology. 118:1986;1977-1981.
2. Belfiore A., Runello F., Sava L., La Rosa G., Vigneri R. Thyroglobulin release after graded endogenous thyrotropin stimulation in man. Lack of correlation with thyroid hormone reponse. J. Clin. Endocrinol. Metab. 59:1984;974-978.
3. Blumenthal H.T., Perlstein I.B. The aging thyroid II: an immunocytochemical analysis of the age-associated lesions. J. Am. Geriatr. Soc. 35:1987;855-859.
4. Bogazzi F., Bartalena L., Gasperi M., Braverman L.E., Martino E. The various effects of amiodarone on thyroid function. Thyroid. 11:2001;511-519. (Review).
5. Cappiello E., Boldorini R., Tosoni A., Piraneo S., Bernasconi R., Raggi U. Ultrastructural evidence of thyroid damage in amiodarone-induced thyrotoxicosis. J. Endocrinol. Invest. 18:1995;862-868.
6. Chiovato L., Mariotti S., Pichera A. Thyroid diseases in the elderly. Baillieres Clin. Endocrinol. Metab. 11:1997;251-270. (Review).
7. Delange, F., Bastani, S., Benmiloud, M., 1986. Definitions of endemic goiter and cretinism, classification of goiter size and severity of endemias, and survey techniques. In: Dunn, J.T., Pretell, E.A., Daza, C.H., Viteri, F.E. (Eds.), Towards the Eradication of Endemic Goiter, Cretinism and Iodine Deficiency, vol. 502. Pan American Health Organization Scientific Publication, Washington, DC, pp. 373-390.
8. Diez J.J. Hypothyroidism in patients older than 55 years: an analysis of the etiology and assessment of the effectiveness of therapy. J. Gerontol. A. Biol. Sci. Med. Sci. 57:2002;M315-M320.
9. Doucet J., Trivalle C., Chassagne P., Perol M.B., Vuillermet P., Manchon N.D., Menard J.F., Bercoff E. Does age play a role in clinical presentation of hypothyroidism? J. Am. Geriatr. Soc. 42:1994;984-986.
10. Faulkner W.R., Demers L.M. Importance of age-dependent reference values in biochemical testing: are we including the elderly population? Clin. Chem. 40:1994;855-856.
11. Gerber H., Huber G., Peter H.J., Kampf J., Lemarchand-Beraud T., Fragu P., Stochker R. Transformation of normal thyroids into colloid goiters in rats and mice by diphenylthiohydantoin. Endocrinology. 135:1994;2688-2699.
12. Gheri, R.G., Biagini, C., Colagrande, S., Cerisano, G., Serio, M., 1990. Application of computed tomographic scanning to predict the occurence of hypothyroidism in amiodarone treated patients. In: Drexhage, H.A., De Vijlder, J.J.M., Wiersinga, W.M. (Eds.), The Thyroid Gland. Environment and Autoimmunity. Elsevier, Amsterdam, pp. 207-210.
13. Grundy, E., 1992. The epidemiology of aging. In: Brocklehurst, J.C., Tallis, R.C., Fillit, H.M. (Eds.), Textbook of Geriatric Medicine and Gerontology, fourth ed. Churchill-Livingstone, Edinburgh, pp. 4-20.
14. Harman S.M., Whemann R.E., Blackman M.R. Pituitary-thyroid hormone economy in healthy aging men: basal indices of thyroid function and thyrotropin reponses to constant infusion of thyrotropin releasing hormone. J. Clin. Endocrinol. Metab. 58:1984;320-326.
15. Hawthorne G.C., Campbell N.P.S., Geddes J.S., Ferguson W.S., Postlethwaite W., Sheridan B., Atkinson A.B. Amiodarone-induced hypothyroidism. A common complication of prolonged therapy. A report of eight cases. Arch. Int. Med. 145:1985;1016-1019.
16. Helfand M., Crapo L.M. Screening for thyroid disease. Ann. Int. Med. 112:1990;840-843.
17. Hermann J., Heinen E., Kroll H.J., Rudorff K.H., Kruskemper H.L. Thyroid function and thyroid hormone metabolism in elderly people. Low T3-syndrome in old age. Klin. Wochenschr. 59:1981;315-318.
18. Hilleman D., Miller M.A., Parker R., Doering P., Pieper J.A. Optimal management of amiodarone therapy: efficacy and side effects. Pharmacotherapy. 18:1998;138S-145S. (Review).
19. Hurwitz J. Interpreting laboratory tests in the elderly. Clin. Biochem. 26:1993;433-434.
20. Inada M., Nishikawa M., Kawai I. Hypothyroidism associated with positive results of the perchlorate discharge test in elderly patients. Am. J. Med. 74:1983;1010-1015.
21. Leovey A., Sztojka I., Paragh G., Mohacsi A. Atypical clinical features of hypo- and hyperthyroidism in elederly age. Ther. Hung. 39:1991;167-174.
22. Leung W.H., Lau C.P., Wong C.K., Wang C. Amiodarone induced thyroiditis. Am. Heart J. 118:1989;848-849.
23. Ligthart G.J., Corberand J.X., Fournier C., Galanaud P., Hijmans W., Kennes B., Muller-Hermelink H.K., Steinmann G.G. Admission criteria for immunogerontological studies in man: the SENIEUR protocol. Mech. Aging Dev. 28:1984;47-55.
24. Ligthart G.J., Corberand J.X., Geertzen H.G., Meinders A.E., Knook D.L., Hijmans W. Necessity of the assessment of health status in human immunogerontological studies: evaluation of the SENIEUR protocol. Mech. Ageing Dev. 55:1990;89-105.
25. Loh K.C. Amiodarone-induced thyroid disorders: a clinical review. Postgrad. Med. J. 76:2000;133-140. (Review).
26. Mariotti S., Sansoni P., Barbesino G., Caturegli P., Monti D., Cossarizza A., Giacomelli T., Passeri G., Fagiolo U., Pinchera A., Franceschi C. Thyroid and other organ-specific autoanti-bodies in healthy centenarians. Lancet. 339:1992;1506-1508.
27. Mariotti S., Barbesino G., Caturegli P., Bartalena L., Sansoni P., Fagnoni F., Monti D., Fagiolo U., Franceschi C., Pinchera A. Complex alteration of thyroid function in healthy centenarians. J. Clin. Endocrinol. Metab. 77:1993;1130-1134.
28. Mariotti S., Chiovato L., Franceschi C., Pinchera A. Thyroid autoimmunity and aging. Exp. Gerontol. 33:1998;535-541. (Review).
29. Mariotti S., Barbesino G., Chiovato L., Marino M., Pinchera A., Zuliani G., Mezzetti A., Fellin R. Circulating thyroid autoantibodies in a sample of Italian octo-nonagenarians: relationship to age, sex, disability, and lipid profile. Aging. 11:1999;362-366.
30. Martino E., Aghini-Lombardi F., Mariotti S., Bartalena L., Lenziardi M., Ceccarelli C., Bambini G., Safran M., Braverman L.E., Pinchera A. Amiodarone iodine-induced-hypothyroidism: risk factors and follow-up in 28 cases. Clin. Endocrinol. 26:1987;227-237.
31. Martino E., Aghini-Lombardi F., Bartalena L., Grasso L., Loviselli A., Velluzzi F., Pinchera A., Braverman L.E. Enhanced susceptibility to amiodarone-induced hypothyroidism in patients with thyroid autoimmune disease. Arch. Intern. Med. 154:1994;2722-2726.
32. Martino E., Bartalena L., Bogazzi F., Braverman L.E. The effects of amiodarone on the thyroid. Endocr. Rev. 22:2001;240-254. (Review).
33. Mc Gregor, A.M., Weetman, A.P., Ratanachaiyavong, S., 1985. Iodine: an influence on the development of autoimmune thyroid disease? In: Hall, R., Köbberling, J. (Eds.), Thyroid Disorders Associated with Iodine Deficiency and Excess. Raven Press, New York, pp. 209-216 (Serono Symposium).
34. Monteiro E., Galvao-Teles A., Santos M.L., Mourao L., Correia M.J., Lopo Tuna J., Ribeiro C. Antithyroid antibodies as an early marker for thyroid disease induced by Amiodarone. Br. Med. J. 292:1986;227-228.
35. Nademanee K., Singh B.N., Callahan B., Hendrickson J.A., Hershman J.M. Amiodarone, thyroid hormone indexes, and altered thyroid function: long-term serial effects in patients with cardiac arrhythmias. Am. J. Cardiol. 58:1986;981-986.
36. Nakajima K., Yamazaki K., Yamada E., Kanaji Y., Kosaka S., Sato K., Takano K. Amiodarone stimulates interleukin-6 production in cultured human thyrocytes, exerting cytotoxic effects on thyroid follicles in suspension culture. Thyroid. 11:2001;101-109.
37. Ordene K.W., Pan C., Barzel U.S., Surks M.I. Variable thyrotropin response to thyrotropin-releasing hormone after small decreases in plasma thyroid hormone concentrations in patients of advanced age. Metabolism. 32:1983;881-888.
38. Robuschi G., Safran N., Braverman L.E., Gnudi A., Roti E. Hypothyroidism in the elderly. Endocr. Rev. 8:1987;142-145.
39. Rowe J.W., Kahn R.L. Human aging: usual and successful. Science. 237:1987;143-149.
40. Sandhu R.S., Davies P.H. Amiodarone induced thyroid dysfunction: pathophysiology diagnosis and management. Adverse Drug React. Toxicol. Rev. 20:2001;105-116. (Review).
41. Tomer Y., Shonfeld Y. Ageing and autoantibodies. Autoimmunity. 1:1988;141-149.
42. Trip M.D., Wiersinga W.M., Plomp T.A. Incidence, predictability, and pathogenesis of amiodarone-induced thyrotoxicosis and hypothyroidism. Am. J. Med. 91:1991;507-515.
43. Tunbridge W.M.G., Evered D.C., Hall R., Appleton D., Brewis M., Clark F., Evans J.G., Young E., Bird T., Smith P.A. The spectrum of thyroid disease in a community: the Whickham survey. Clin. Endocrinol. 7:1977;481-483.
44. Unger J., Lambert M., Jonckeer M.H., Denayer P. Amiodarone and the thyroid: pharmacological, toxic and therapeutic effects. J. Intern. Med. 233:1993;435-443.
45. Vandenberghe H. The role of the laboratory in geriatric medicine: overview. Clin. Chem. 26:1993;427-428.
46. Wiersinga, W.M., Decoulx, M., Grimbert, I., 1985. Thyroid radioisotope uptake is preserved in iodine-induced hypothyroidism, but not in iodine-induced thyrotoxicosis or in euthyroidism during iodide excess. In: Hall, R., Köbberling, J. (Eds.), Thyroid Disorders Associated with Iodine Deficiency or Excess. Raven Press, New York, pp. 197-200.
47. Wollman S.H., Herveg J.P., Tachiwaki O. Histologic changes in tissue components of the hyperplastic thyroid gland during its involution in the rat. Am. J. Anat. 189:1990;35-44.