Activation of Chloride Secretion in Cystic Fibrosis Cells and Tissues by the Substituted Imidazole SRI 2931

Biochemistry

Volumn 42, Issue 45, 2003, Pages 13241-13249

  Jones, Julie R ^c   Schwiebert, Erik M ^a   DuVall, Michael D ^a   Venglarik, Charles J ^a   Wen, Hui ^a   Kovacs, Timea ^a   Mazur, Marina ^a   Clancy, John P ^a   Braunstein, Gavin ^a   Bates, Eleanor ^a   Greer, Heather ^a   Maddry, Joseph A ^b   Sorscher, Eric J ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORINE COMPOUNDS; NEGATIVE IONS; NUCLEIC ACIDS; TISSUE;

CYSTIC FIBROSIS (CF);

CELLS;

ACETAZOLAMIDE; ADENOSINE TRIPHOSPHATE; AMILORIDE; CHLORIDE; CYCLIC AMP; EGTAZIC ACID; HETEROCYCLIC COMPOUND; HEXOKINASE; IMIDAZOLE; NUCLEOSIDE; NUCLEOTIDE; SRI 2931; STAUROSPORINE; SURAMIN;

ANION TRANSPORT; ARTICLE; CELL PROLIFERATION; CHLORIDE TRANSPORT; CONTROLLED STUDY; CYSTIC FIBROSIS; EPITHELIUM CELL; HUMAN; HUMAN CELL; PANCREAS CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL DIVISION; CELL LINE, TUMOR; CELLS, CULTURED; CHLORIDE CHANNELS; CHLORIDES; COLON; CYSTIC FIBROSIS; DRUG EVALUATION, PRECLINICAL; HUMANS; IMIDAZOLES; INTESTINAL MUCOSA; ION TRANSPORT; MICE; MICE, INBRED CFTR; NASAL POLYPS; PATCH-CLAMP TECHNIQUES; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION;

EID: 10744224128     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0340447     Document Type: Article

References (21)

1. Sorscher, E. J. (1997) Cystic Fibrosis, Molecular Genetics, in Encyclopedia of Human Biology (Dulbecco, R., Ed.) 2nd ed., pp 107-114, Academic Press, San Diego.
2. Welsh, M. J., Ramsey, B. W., Accurso, F. J., and Cutting, G. R. (2001) Cystic Fibrosis, in The Metabolic and Molecular Bases of Inherited Disease (Scriver, C. R. et al., Eds.) 8th ed., pp 5121-5188, McGraw-Hill, New York.
3. Ma, T., Vetrivel, L., Yang, H., Pedemonte, N., Zegarra-Moran, O., Galietta, L. J., and Verkman, A. S. (2002) High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening, J. Biol. Chem. 277, 37235-37241.
4. Knowles, M. R., Clarke, L. L., and Boucher, R. C. (1991) Activation by extracellular nucleotides of chloride secretion in the airway epithelia of patients with cystic fibrosis, N. Engl. J. Med 325, 533-538.
5. Mason, S. J., Paradiso, A. M., and Boucher, R. C. (1991) Regulation of transepithelial ion transport and intracellular calcium by extracellular ATP in human normal and cystic fibrosis airway epithelium, Br. J. Pharmacol. 103, 1649-1656.
6. Stutts, M. J., Fitz, J. G., Paradiso, A. M., and Boucher, R. C. (1994) Multiple modes of regulation of airway epithelial chloride secretion by extracellular ATP, Am. J. Physiol. 267, C1442-C1451.
7. Cantiello, H. F., Prat, A. G., Reisin, I. L., Ercole, L. B., Abraham, E. H., Amara, J. F., Gregory, R. J., and Ausiello, D. A. (1994) External ATP and its analogues activate the cystic fibrosis transmembrane conductance regulator by a cyclic AMP-independent mechanism, J. Biol. Chem. 269, 11224-11232.
8. - conductance in polarized T84 cells by luminal extracellular ATP, Am. J. Physiol. 268, C425-C433.
9. Hwang, T. H., Schwiebert, E. M., and Guggino, W. B. (1996) Apical and basolateral ATP stimulates tracheal epithelial chloride secretion via multiple purinergic receptors, Am. J. Physiol. 270, C1611-C1623.
10. - currents activated by extracellular nucleotides in human bronchial cells, J. Membr. Biol. 156, 297-305.
11. Schoumacher, R. A., Ram, J., Iannuzzi, M. C., Bradbury, N. A., Wallace, R. W., Hon, C. T., Kelly, D. R., Schmid, S. M., Gelder, F. B., and Rado, T. A. (1990) A cystic fibrosis pancreatic adenocarcinoma cell line, Proc. Natl. Acad. Sci. U.S.A. 87, 4012-4016.
12. Drumm, M. L., Pope, H. A., Cliff, W. H., Rommens, J. M., Marvin, S. A., Tsui, L. C., Collins, F. S., Frizzell, R. A., and Wilson, J. M. (1990) Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer, Cell 62, 1227-1233.
13. - transport across the isolated turtle colon: parallel pathways for transmural ion movement, J. Membr. Biol. 37, 213-233.
14. Venglarik, C. J., Bridges, R. J., and Frizzell, R. A. (1990) A simple assay for agonist-regulated Cl and K conductances in salt-secreting epithelial cells, Am. J. Physiol. 259, C358-C364.
15. Taylor, A. L., Kudlow, B. A., Marrs, K. L., Gruenert, D. C., Guggino, W. B., and Schwiebert, E. M. (1998) Bioluminescence detection of ATP release mechanisms in epithelia, Am. J. Physiol. 275, C1391-C1406.
16. 2, Am. J. Physiol. 282(1), L12-L25.
17. Clancy, J. P., Ruiz, F. E., and Sorscher, E. J. (1999) Adenosine and its nucleotides activate wild type and R117H CFTR through the A2b receptor-coupled pathway, Am. J. Physiol. 276, C361-C369.
18. Widdicombe, J. H., and Widdicombe, J. G. (1995) Regulation of human airway surface liquid, Respir. Physiol. 99, 3-12.
19. Gao, L. J., Broughman, R., Iwamoto, T., Tomich, J. M., Venglarik, C. J., and Forman, H. J. (2001) Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia, Am. J. Respir. Cell Mol. Biol. 281, L24-L30.
20. Kelley, T. J., al-Nakkash, L., and Drumm, M. L. (1995) CFTR-mediated chloride permeability is regulated by type III phosphodiesterases in airway epithelial cells, Am. J. Respir. Cell Mol. Biol. 13, 657-664.
21. Schwiebert, E. M., Egan, M. E., Hwang, T. H., Fulmer, S. B., Allen, S. S., Cutting, G. R., and Guggino, W. B. (1995) CFTR regulates outwardly rectifying chloride channels through and autocrine mechanism involving ATP, Cell 81, 1063-1073.