Current therapeutic approaches in childhood chronic hepatitis B infection: A multicenter study

Journal of Gastroenterology and Hepatology (Australia)

Volumn 19, Issue 2, 2004, Pages 127-133

  Dikici, Bunyamin ^a   Ozgenc, Funda ^b   Kalayci, Ayhan Gazi ^e   Targan, Seref ^c   Ozkan, Tanju ^f   Selimoglu, Ayse ^g   Doganci, Tumay ^h   Kansu, Aydan ^h   Tosun, Selma ⁱ   Arslan, Nur ^d   Kasirga, Erhun ⁱ   Bosnak, Mehmet ^a   Haspolat, Kenan ^a   Buyukgebiz, Benal ^d   Aydogdu, Sema ^b   Girgin, Nurten ^h   Yagci, Rasit Vural ^b  

^a DICLE UNIVERSITY   (Turkey)

^b EGE UNIVERSITY   (Turkey)

^c Behcet Uz Children's Hospital   (Turkey)

^d DOKUZ EYLUL UNIVERSITY   (Turkey)

^e ONDOKUZ MAYIS UNIVERSITY   (Turkey)

^f ULUDAG UNIVERSITY   (Turkey)

^g ATATURK UNIVERSITY   (Turkey)

^h ANKARA UNIVERSITY   (Turkey)

ⁱ CELAL BAYAR UNIVERSITY   (Turkey)

Author keywords

Children; Chronic hepatitis B; Interferon ; Lamivudine; Therapy

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA2B INTERFERON; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; VIRUS DNA;

ABDOMINAL PAIN; ADOLESCENT; ALOPECIA; ARTHRALGIA; ARTICLE; CHILD; CHRONIC HEPATITIS; CLEARANCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; FATIGUE; FEMALE; FLU LIKE SYNDROME; GASTROINTESTINAL SYMPTOM; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; INJECTION; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MULTICENTER STUDY; MYALGIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEROCONVERSION; TREATMENT OUTCOME; WEIGHT REDUCTION;

EID: 10744221461     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2004.03209.x     Document Type: Article

References (29)

1. Rivkina A, Rybalov S, Chronic hepatitis B: current and future treatment options. Pharmacotherapy 2002; 22: 721-37.
2. Centers for Disease Control and Prevention. Hepatitis B virus: a comprehensive strategy for eliminating transmission in the United States through universal childhood vaccination. Recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR Recomm. Report 1991; 40: 1-25.
3. Braden GL. Treatment of Hepatitis B. Available from URL: http://www.medscape.com/viewarticle/434534
4. Wai CT, Lok AS. Treatment of hepatitis B. J. Gastroenterol. 2002; 37: 771-8.
5. Demirturk N, Usluer G, Ozgunes I, Colak H, Kartal ED, Dincer S. Comparison of different treatment combinations for chronic hepatitis B infection. J. Chemother. 2002; 14: 285-9.
6. Lok ASF, Chung HT, Liu VWS et al. Long-term follow-up of chronic hepatitis B patients treated with IFN-alpha. Gastroenterology 1993; 105: 1833-8.
7. Matthews GV, Nelson MR. The management of chronic hepatitis B infection. Int. J. STD AIDS 2001; 12: 353-7.
8. Bortolotti F. Treatment of chronic hepatitis B in children. J. Hepatol. 2003; 39(Suppl. 1): 200-5.
9. Knodell RG, Ishak KG, Black WC et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431-5.
10. Szmuness W. Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association. Prog. Med. Virol. 1978; 24: 40-69.
11. Mast EE, Alter MJ, Margolis HS. Strategies to prevent and control hepatitis B and C virus infections: a global perspective. Vaccine 1999; 17: 1730-1733.
12. Alberti A, Brunetto MR, Colombo M, Craxi A. Recent progress and new trends in the treatment of hepatitis B. J. Med. Virol. 2002; 67: 458-62.
13. Sokal E. Drug treatment of pediatric chronic hepatitis B. Paediatr. Drugs 2002; 4: 361-9.
14. Gurakan F, Kocak N, Ozen H, Yuce A. Comparison of standard and high dosage recombinant IFN-alpha 2b for treatment of children with chronic hepatitis B infection. Pediatr. Infect. Dis. J. 2000; 19: 52-6.
15. Boni C, Penna A, Ogg GS et al. LAM treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy. Hepatology 2001; 33: 963-71.
16. Boni C, Bertoletti A, Penna A et al. LAM treatment can restore T cell responsiveness in chronic hepatitis. J. Clin. Invest. 1998; 102: 867.
17. Liaw YF. Therapy of chronic hepatitis B: current challenges and opportunities. J. Viral Hepat. 2002; 9: 393-9.
18. Lewin S, Walters T, Locarnini S. Hepatitis B treatment: rational combination chemotherapy based on viral kinetic and animal model studies. Antiviral Res. 2002; 55: 381-96.
19. Schalm SW, Heathcote J, Cianciara J et al. LAM and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomized trial. Gut 2000; 46: 562-8.
20. Barbaro G, Zechini F, Pellicelli AM et al. Long-term efficacy of IFN-alpha-2b and LAM in combination compared to LAM monotherapy in patients with chronic hepatitis B. An Italian multicenter, randomized trial (Abstract). Hepatology 2001; 34: 319.
21. Dikici B, Bosnak M, Kara IH et al. Lamivudine and interferon-alpha combination treatment of childhood patients with chronic hepatitis B infection. Pediatr. Infect. Dis. J. 2001; 20: 988-92.
22. Dikici B, Bosnak M, Bosnak V et al. Combination therapy for children with chronic hepatitis B virus infection. J. Gastroenterol. Hepatol. 2002; 17: 1087-91.
23. Brook MG, Karayiannis P, Thomas HC. Which patients with chronic hepatitis B virus infection will respond to alpha-interferon therapy? A statistical analysis of predictive factors. Hepatology 1990; 12: 180-1.
24. Yao G, Wang B, Cui Z, Yao J, Zeng M. A randomized double-blind placebo-controlled study of lamivudine in the treatment of patients with chronic hepatitis B virus infection. Chin. Med. J. 1999; 112: 387-91.
25. Schenker BM, Zamora S, Benkebil F, Roulet M, Schibli S, Belli DC. Treatment of Chronic Hepatitis B in Children with a Combination of LAM and Alpha Interferon is not Better than with Alpha Interferon Alone. 34th Annual Meeting of ESPGHAN; May 9-12, Geneva, Switzerland. Geneva: ESPGHAN, 2001: 77.
26. Farrell G. Hepatitis B e antigen seroconversion: effects of LAM alone or in combination with IFN-alpha. J. Med. Virol. 2000; 61: 374-9.
27. Conjeevaram HS, Lok AS. Management of chronic hepatitis B. J. Hepatol. 2003; 38: 90-103.
28. Saracco G, Rizzetto M. A practical guide to the use of interferons in the management of hepatitis virus infections. Drugs 1997; 53: 74-85.
29. Mutimer D. Hepatitis B virus antiviral drug resistance: from the laboratory to the patient. Antivir. Ther. 1998; 3: 243-6.