Alterations of tumor suppressor genes (Rb, p16, p27 and p53) and an increased FDG uptake in lung cancer

Annals of Nuclear Medicine

Volumn 17, Issue 3, 2003, Pages 189-196

  Sasaki, Masayuki ^a   Sugio, Kenji ^a   Kuwabara, Yasuo ^a   Koga, Hirofumi ^a   Nakagawa, Makoto ^a   Chen, Tao ^a   Kaneko, Koichiro ^a   Hayashi, Kazutaka ^a   Shioyama, Yoshiyuki ^a   Sakai, Shuji ^a   Honda, Hiroshi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

FDG; Lung cancer; PET; Tumor suppressor gene

Indexed keywords

ACTIN ASSOCIATED PROTEIN, P27; ACTIN BINDING PROTEIN; ACTIN-ASSOCIATED PROTEIN, P27; DIAGNOSTIC AGENT; FLUORODEOXYGLUCOSE; FLUORODEOXYGLUCOSE F 18; PROTEIN P16; PROTEIN P27; PROTEIN P53; RADIOPHARMACEUTICAL AGENT; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; ARTICLE; CARCINOMA; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG TUMOR LEVEL; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL CARCINOMA; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG TUMOR; MALE; METABOLISM; METHODOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCINTISCANNING; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

EID: 10744219929     PISSN: 09147187     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02990021     Document Type: Article

References (40)

1. 18F]fluorodeoxyglucose and positron emission tomography. Neurology 1982; 32: 1323-1329.
2. Leskinen-Kallio S, Ruotsalainen U, Någren K, Teräs M, Joensuu H. Uptake of carbon-11-methionine and fluorodeoxyglucose in non-Hodgkin's lymphoma: a PET study. J Nucl Med 1991; 32: 121-128.
3. Higashi K, Ueda Y, Seki H. F-18 FDG PET imaging is negative in bronchioloalveolar lung carcinoma. J Nucl Med 1998; 39: 1016-1020.
4. Vesselle H, Schmidt RA, Pugsley JM, Li M, Kohlmyer SG, Vallières E, et al. Lung cancer proliferation correlates with [F-18]fluorodeoxyglucose uptake by positron emission tomography. Clin Cancer Res 2000; 6: 3837-3844.
5. Higashi K, Ueda Y, Ayabe K, Sakurai A, Seki H, Nambu Y, et al. FDG PET in the evaluation of the aggressiveness of pulmonary adenocarcinoma: correlation with histopathological features. Nucl Med Commun 2000; 21: 707-714.
6. Duhaylongsod FG, Lowe VJ, Ratz EF, Vaughn AL, Coleman RE, Wolfe WG. Lung tumor growth correlations with glucose metabolism measured by fluoride-18 fluorodeoxyglucose positron emission tomography. Ann Thorac Surg 1995; 60: 1348-1362.
7. Higashi K, Ueda Y, Yagishita M. FDG PET measurement of the proliferative potential of non-small cell lung cancer. J Nucl Med 2000; 41: 85-92.
8. Xu HJ, Quinlan DC, Davidson AG, Hu SX, Summers CL, Li J, et al. Altered retinoblastoma protein expression and prognosis in early-stage non-small cell lung carcinoma. J Natl Cancer Inst 1994; 86: 695-699.
9. Tomizawa Y, Kohno T, Fujita T, Kiyama M, Saito R, Noguchi M, et al. Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma. Oncogene 1999; 18: 1007-1014.
10. Kip in non-small cell lung carcinoma: a prognostic factor independent of Ras. Cancer Res 1999; 59: 684-688.
11. Kip1 correlates with a shortened survival in non-small cell lung cancer. Lung Cancer 2001; 34: 83-90.
12. Ng CS, Zhang J, Wan S, Lee TW, Arifi AA, Mok T, et al. Tumor p16M is a possible marker of advanced stage in non-small cell lung cancer. J Surg Oncol 2002; 79: 101-106.
13. Sugio K, Tsukamoto S, Ushijima C, Yamazaki K, Kase S, Yamaguchi M, et al. Clinical significance of the Rb expression in adenocarcinoma of the lung. Anticancer Research 2001; 21: 1931-1936.
14. Koga T, Hashimoto S, Sugio K, Yoshino I, Nakagawa K, Yonemitsu Y, et al. Heterogeneous distribution of p53 immunoreactivity in human lung adenocarcinoma correlates with MDM2 protein expression, rather than with p53 gene mutation. Int J Cancer (Pred Oncol) 2001; 95: 232-239.
15. Mishina T, Dosaka-Akita H, Kinoshita I, Hommura F, Morikawa T, Katoh H, et al. Cyclin D1 expression in non-small cell lung cancers: its association with altered p53 expression, cell proliferation and clinical out come. Br J Cancer 1999; 80: 1289-1295.
16. Xu HJ, Hu SX, Cagle PT, Moore GE, Benedict WF. Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas. Cancer Res 1991; 51: 2735-2739.
17. Reissmann PT, Koga H, Takahashi R, Figlin RA, Holmes EC, Piantadosi S, et al. Inactivation of the retinoblastoma susceptibility gene in non-small cell lung cancer. The Lung Cancer Study Group. Oncogene 1993; 8: 1913-1919.
18. Dosaka-Akita H, Hu SX, Fujino M, Harada M, Kinoshita I, Hu HJ, et al. Altered retinoblastoma protein expression in non-small cell lung carcinoma: its synergistic effects with altered ras and p53 protein status on prognosis. Cancer 1997; 79: 1329-1337.
19. Brambilla E, Gazzeri S, Lantuejoul S, Coll JL, Moro D, Negoescu A, et al. p53 mutant immunophenotype and deregulation of p53 transcription pathway (Bc2, Bax, and Waf1) in precursor bronchial lesions of lung cancer. Clin Cancer Res 1998; 4: 1609-1618.
20. Brambilla E, Gazzeri S, Moro D, Lantuejoul S, Veyrenc S, Brambilla C. Alterations of Rb pathway (Rb-p16INK4-cyclin D1) in preinvasive bronchial lesions. Clin Cancer Res 1999; 5: 243-250.
21. Kawasaki M, Noguchi M, Morikawa A, Matsuno Y, Yamada T, Hirohashi S, et al. Nuclear p53 accumulation by small-sized adenocarcinomas of the lung. Pathol Int 1996; 46: 486-490.
22. Passlick B, Izbicki JR, Haussinger K, Thetter O, Pantel K. Immunohistochemical detection of p53 protein is not associated with a prognosis in non-small cell lung cancer. J Thorac Cardiovasc Surg 1995; 109: 1205-1211.
23. Huang C-I, Taki T, Higashiyama M, Kohno N, Miyake M. p16 protein expression is associated with a poor prognosis in squamous cell carcinoma of the lung. Br J Cancer 2000; 82: 374-380.
24. Gould MK, Maclean CC, Kuschner WG, Rydzak CE, Owens DK. Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesion: a metaanalysis. JAMA 2001; 285: 914-924.
25. Sasaki M, Kuwabara Y, Yoshida T, Nakagawa M, Koga H, Hayashi K, et al. Comparison of MET-PET and FDG-PET for differentiation between benign lesions and malignant tumors of the lung. Ann Nucl Med 2001; 15: 425-431.
26. Sasaki M, Ichiya Y, Kuwabara Y, Akashi Y, Yoshida T, Fukumura T, et al. The usefulness of FDG positron emission tomography for the detection of mediastinal lymph node metastases in patients with non-small cell lung cancer: a comparative study with X-ray computed tomography. Eur J Nucl Med 1996; 23: 741-747.
27. Dwamena BA, Sonnad SS, Angobaldo JO, Wahl RL. Metastases from non-small cell lung cancer: mediastinal staging in the 1990s - meta-analytic comparison of PET and CT. Radiology 1999; 213: 530-536.
28. Marom EM, McAdams HP, Erasmus JJ, Goodman PC, Culhane DK, Coleman RE, et al. Staging non-small cell lung cancer with whole-body PET. Radiology 1999; 212: 803-809.
29. 18F-fluoro-2-deoxy-glucose-positron emission tomography scan in non-small cell lung cancer: an analysis of 125 cases. J Clin Oncol 1999; 17: 3201-3206.
30. Kubota R, Kubota K, Yamada S, Tada Y, Ido T, Tamahashi N. Microautoradiographic study for the differentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics of fluorine-18-fluorodeoxyglucose uptake. J Nucl Med 1994; 35: 104-112.
31. Minn H, Clavo AC, Grénman R, Wahl RL. In vitro comparison of cell proliferation kinetics and uptake of tritiated fluorodeoxyglucose and L-methionine in squamous-cell carcinoma of the head and neck. J Nucl Med 1995; 36: 252-258.
32. Haberkorn U, Strauss LG, Reisser C, Haag D, Dimitrakopoulou A, Ziegler S, et al. Glucose uptake, perfusion, and cell proliferation in head and neck tumors: relationship of positron emission tomography to flow cytometry. J Nucl Med 1991; 32: 1548-1555.
33. Okada J, Yoshikawa K, Itami M, Imaseki K, Uno K, Itami J, et al. Positron emission tomography using fluorine-18-fluorodeoxyglucose in malignant lymphoma: a comparison with proliferative activity. J Nucl Med 1992; 33: 325-329.
34. 18F-FDG PET: histologic and immunohistochemical tissue analysis. J Nucl Med 2001; 42: 9-16.
35. Jacob R, Welkoborsky HJ, Mann WJ, Jauch M, Amedee R. [Fluorine-18]fluoro-deoxyglucose positron emission tomography, DNA ploidity and growth fraction in squamous-cell carcinomas of the head and neck. ORL Otorhinolaryngol Relat Spec 2001; 63: 307-313.
36. Higashi K, Clavo AC, Wahl RL. Does FDG uptake measure proliferative activity of human cancer cells? In vitro comparison with DNA flow cytometry and tritiated thymidine uptake. J Nucl Med 1993; 34: 414-419.
37. Haberkorn U, Ziegler SI, Oberdorfer F, Trojan H, Haag D, Peschke P, et al. FDG uptake, tumor proliferation and expression of glycolysis associated genes in animal tumor models. Nucl Med Biol 1994; 21: 827-834.
38. Minn H, Lapela M, Klemi PJ, Grénman R, Leskinen S, Lindholm P, et al. Prediction of survival with fluorine-18-fluoro-deoxyglucose and PET in head and neck cancer. J Nucl Med 1997; 38: 1907-1911.
39. Buck AC, Schirrmeister HH, Guhlmann C-A, Diederichs CG, Shen C, Buchmann I, et al. Ki-67 immunostaining in pancreas cancer and chronic active pancreatitis: Does in vivo FDG uptake correlate with proliferative activity? J Nucl Med 2001; 42: 721-725.
40. 68Ge transmission scan in PET study. KAKU IGAKU (Jpn J Nucl Med) 1994; 31: 1511-1517. (in Japanese)