Type I allergy to elderberry (Sambucus nigra) is elicited by a 33.2 kDa allergen with significant homology to ribosomal inactivating proteins

Clinical and Experimental Allergy

Volumn 33, Issue 12, 2003, Pages 1703-1710

  Forster Waldl E ^a   Marchetti, M ^b   Scholl I ^a   Focke, M ^a   Radauer, C ^a   Kinaciyan, T ^c   Nentwich, I ^d   Jager S ^a   Schmid, E R ^b   Boltz Nitulescu, G ^a   Scheiner, O ^a   Jensen Jarolim, E ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c Universitatsklinik fur Dermatologie   (Austria)

^d MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Berries; Elderberry flower; IgE; Pollen; Ribosomal inactivating protein (RIP); Sambucus nigra; Type I allergy

Indexed keywords

ALLERGEN; PROTEIN; RIBOSOMAL INACTIVATING PROTEIN; UNCLASSIFIED DRUG;

ALLERGENICITY; ALLERGIC RHINITIS; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS REACTION; DYSPNEA; HAY FEVER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMEDIATE TYPE HYPERSENSITIVITY; IMMUNOBLOTTING; ISOELECTRIC POINT; MASS SPECTROMETRY; PATHOGENESIS; PEPTIDE MAPPING; PH; POLLEN; PRICK TEST; PRIORITY JOURNAL; PROTEIN PURIFICATION; RADIOALLERGOSORBENT TEST; RHINOCONJUNCTIVITIS; SAMBUCUS NIGRA; SENSITIZATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SKIN TEST; SUMMER; SYMPTOM; TWO DIMENSIONAL ELECTROPHORESIS;

ALLERGENS; ANIMALS; BASE SEQUENCE; CROSS REACTIONS; FLOWERS; FRUIT; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; N-GLYCOSYL HYDROLASES; PLANT EXTRACTS; PLANT PROTEINS; POLLEN; SAMBUCUS NIGRA; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 10744219712     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2003.01811.x     Document Type: Article

References (32)

1. Van Damme EJ, Peumans WJ, Barre A, Rougé P. Plant lectins. A composite of several distinct families of structurally and evolutionary related proteins with diverse biological roles. In: Critical reviews in plant sciences. Boca Raton, FL, 1998; 575-692.
2. Baum LG, Derbin K, Perillo NL, Wu T, Pang M, Uittenbogaart C. Characterization of terminal sialic acid linkages on human thymocytes. Correlation between lectin-binding phenotype and sialyltransferase expression. J Biol Chem 1996; 271:10793-9.
3. Chintalacharuvu SR, Emancipator SN. The glycosylation of IgA produced by murine B cells is altered by Th2 cytokines. J Immunol 1997; 159:2327-33.
4. Tong HH, James M, Grants I, Liu X, Shi G, DeMaria TF. Comparison of structural changes of cell surface carbohydrates in the eustachian tube epithelium of chinchillas infected with a Streptococcus pneumoniae neuraminidase-deficient mutant or its isogenic parent strain. Microb Pathogen 2001; 31:309-17.
5. Durham S. ABC of allergies. Summer hay fever. BMJ 1998; 316:843-5.
6. Chen Y, Peumans WJ, Van Damme EJ. The Sambucus nigra type-2 ribosome-inactivating protein SNA-I' exhibits in planta antiviral activity in transgenic tobacco. FEBS Lett 2002; 516:27-30.
7. Au TK, Collins RA, Lam TL, Ng TB, Fong WP, Wan DC. The plant ribosome inactivating proteins luffin and saporin are potent inhibitors of HIV-1 integrase. FEBS Lett 2000; 471:169-72.
8. Wang YX, Jacob J, Wingfield PT et al. Anti-HIV and anti-tumor protein MAP30, a 30 kDa single-strand type-I RIP, shares similar secondary structure and beta-sheet topology with the A chain of ricin, a type-II RIP. Protein Sci 2000; 9:138-44.
9. Citores L, Miguel Ferreras J, Munoz R, Benitez J, Jimenez P, Girbes T. Targeting cancer cells with transferrin conjugates containing the non-toxic type 2 ribosome-inactivating proteins nigrin b or ebulin 1. Cancer Lett 2002; 184:29-35.
10. Sibbald B, Barnes G, Durham SR. Skin prick testing in general practice: a pilot study. J Adv Nurs 1997; 26:537-42.
11. Jensen-Jarolim E, Gerstmayer G, Kraft D, Scheiner O, Ebner H, Ebner C. Serological characterization of allergens in poppy seeds. Clin Exp Allergy 1999; 29:1075-9.
12. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248-54.
13. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680-5.
14. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. 1979. Biotechnology 1992; 24:145-9.
15. Görg A, Postel W, Gunther S. The current state of two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis 1988; 9:531-46.
16. Gill SC, von Hippel PH. Calculation of protein extinction coefficients from amino acid sequence data. Anal Biochem 1989; 182:319-26.
17. Kussmann M, Roepstorff P. Sample preparation techniques for peptides and proteins analyzed by MALDI-MS. Methods Mol Biol 2000; 146:405-24.
18. Shevchenko A, Wilm M, Vorm O, Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem 1996; 68:850-8.
19. Van Damme EJ, Roy S, Barre A, Rouge P, Van Leuven F, Peumans WJ. The major elderberry (Sambucus nigra) fruit protein is a lectin derived from a truncated type 2 ribosome-inactivating protein. Plant J 1997; 12:1251-60.
20. Van Damme EJ, Barre A, Rouge P, Van Leuven F, Peumans WJ. Isolation and molecular cloning of a novel type 2 ribosome-inactivating protein with an inactive B chain from elderberry (Sambucus nigra) bark. J Biol Chem 1997; 272:8353-60.
21. Rodriguez M, Vega F, Garcia MT et al. Hypersensitivity to latex, chestnut, and banana. Ann Allergy 1993; 70:31-4.
22. Gall H, Kalveram KJ, Forck G, Sterry W. Kiwi fruit allergy: a new birch pollen-associated food allergy. J Allergy Clin Immunol 1994; 94:70-6.
23. Blanco C, Carrillo T, Castillo R, Quiralte J, Cuevas M. Avocado hypersensitivity. Allergy 1994; 49:454-9.
24. Jensen-Jarolim E, Leitner A, Hirschwehr R et al. Characterization of allergens in Apiaceae spices: anise, fennel, coriander and cumin. Clin Exp Allergy 1997; 27:299-306.
25. Reider N, Sepp N, Fritsch P, Weinlich G, Jensen-Jarolim E. Anaphylaxis to camomile: clinical features and allergen cross-reactivity. Clin Exp Allergy 2000; 30:1436-43.
26. Jarolim E, Rumpold H, Endler AT et al. IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Betula verrucosa. Allergy 1989; 44:385-95.
27. Ferreira F, Hirtenlehner K, Jilek A et al. Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: potential use of hypoallergenic isoforms for immunotherapy. J Exp Med 1996; 183:599-609.
28. Breitenbach M, Ferreira F, Jilek A et al. Biological and immunological importance of Bet v 1 isoforms. Adv Exp Med Biol 1996; 409:117-26.
29. Ganglberger E, Sponer B, Schöll I et al. IgE mimotopes are safe for therapy of type I allergy when presented as monovalent fusion proteins. FASEB J 2001; 15:254-56.
30. Valenta R, Duchene M, Ebner C et al. Profilins constitute a novel family of functional plant pan-allergens. J Exp Med 1992; 175:377-85.
31. Breiteneder H, Ebner C. Molecular and biochemical classification of plant-derived food allergens. J Allergy Clin Immunol 2000; 106:27-36.
32. Mikkola JH, Alenius H, Kalkkinen N, Turjanmaa K, Palosuo T, Reunala T. Hevein-like protein domains as a possible cause for allergen cross-reactivity between latex and banana. J Allergy Clin Immunol 1998; 102:1005-12.