메뉴 건너뛰기




Volumn 1033, Issue , 2004, Pages 139-146

Acetyl-L-carnitine for the Treatment of HIV Lipoatrophy

Author keywords

Adipose; Antiretroviral; Fat; Lipodystrophy; Nucleoside reverse transcriptase inhibitor

Indexed keywords

ANTIRETROVIRUS AGENT; CARNITINE; LEVACECARNINE; NICOTINIC ACID; PIOGLITAZONE; PROTEINASE INHIBITOR; RIBOFLAVIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; THIAMINE; UBIDECARENONE; ZIDOVUDINE;

EID: 10644267458     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1320.013     Document Type: Conference Paper
Times cited : (10)

References (46)
  • 1
    • 0036840147 scopus 로고    scopus 로고
    • Management of metabolic complications associated with antiretroviral therapy for HIV-1 infection: Recommendations of an Intermitional AIDS Society-USA panel
    • SCHAMBELAN, M. et al. 2002. Management of metabolic complications associated with antiretroviral therapy for HIV-1 infection: recommendations of an Intermitional AIDS Society-USA panel. J. Acquired Immune Defic. Syndr. 31: 257-275.
    • (2002) J. Acquired Immune Defic. Syndr. , vol.31 , pp. 257-275
    • Schambelan, M.1
  • 2
    • 0036737110 scopus 로고    scopus 로고
    • Abnormalities of body fat distribution in HIV-infected persons treated with antiretroviral drugs: The Swiss HIV Cohort Study
    • BERNASCONI, E. et al. 2002. Abnormalities of body fat distribution in HIV-infected persons treated with antiretroviral drugs: the Swiss HIV Cohort Study. J. Acquired Immune Defic. Syndr. 31: 50-55.
    • (2002) J. Acquired Immune Defic. Syndr. , vol.31 , pp. 50-55
    • Bernasconi, E.1
  • 3
    • 0035951473 scopus 로고    scopus 로고
    • Lipodystrophy-associated morphological, cholesterol, and triglyceride abnormalities in a population-based HIV/AIDS treatment database
    • HEATH, K.V. et al. 2001. Lipodystrophy-associated morphological, cholesterol, and triglyceride abnormalities in a population-based HIV/AIDS treatment database. AIDS 15: 231-239.
    • (2001) AIDS , vol.15 , pp. 231-239
    • Heath, K.V.1
  • 4
    • 0036683037 scopus 로고    scopus 로고
    • Antiretroviral treatment patterns and incident HIV-associated morphologic and lipid abnormalities in a population-based cohort
    • HEATH, K.V. et al. 2002. Antiretroviral treatment patterns and incident HIV-associated morphologic and lipid abnormalities in a population-based cohort. J. Acquired Immune Defic. Syndr. 30: 440-447.
    • (2002) J. Acquired Immune Defic. Syndr. , vol.30 , pp. 440-447
    • Heath, K.V.1
  • 5
    • 18044376212 scopus 로고    scopus 로고
    • Lipodystrophy, metabolic disorders, and human immunodeficiency virus infection: Aquitaine Cohort, France, 1999
    • THIEBAUT, R. et al. 2000. Lipodystrophy, metabolic disorders, and human immunodeficiency virus infection: Aquitaine Cohort, France, 1999 Clin. Infect. Dis. 31: 1482-1487.
    • (2000) Clin. Infect. Dis. , vol.31 , pp. 1482-1487
    • Thiebaut, R.1
  • 6
    • 0035958793 scopus 로고    scopus 로고
    • Clinical assessment of HIV-associated lipodystrophy in an ambulatory population
    • LICHTENSTEIN, K.A. et al. 2001. Clinical assessment of HIV-associated lipodystrophy in an ambulatory population. AIDS 15: 1389-1398.
    • (2001) AIDS , vol.15 , pp. 1389-1398
    • Lichtenstein, K.A.1
  • 7
    • 0037093813 scopus 로고    scopus 로고
    • Factors related to lipodystrophy and metabolic alterations in patients with human immunodeficiency virus infection receiving highly active anti-retroviral therapy
    • SAVÉS, M. et al. 2002. Factors related to lipodystrophy and metabolic alterations in patients with human immunodeficiency virus infection receiving highly active anti-retroviral therapy. Clin. Infect. Dis. 34: 1397-1405.
    • (2002) Clin. Infect. Dis. , vol.34 , pp. 1397-1405
    • Savés, M.1
  • 8
    • 0037049347 scopus 로고    scopus 로고
    • Incidence of adipose tissue alterations in first-line antiretroviral therapy: The LipoICoNa study
    • GALLI, M. et al. 2002. Incidence of adipose tissue alterations in first-line antiretroviral therapy: the LipoICoNa study. Arch. Intern. Med. 162: 2621-2628.
    • (2002) Arch. Intern. Med. , vol.162 , pp. 2621-2628
    • Galli, M.1
  • 9
    • 0041914142 scopus 로고    scopus 로고
    • Gender differences in antiretroviral drug-related adipose tissue alterations
    • GALLI, M. et al. 2003. Gender differences in antiretroviral drug-related adipose tissue alterations. J. Acquired Immune Defic. Syndr. 34: 58-61.
    • (2003) J. Acquired Immune Defic. Syndr. , vol.34 , pp. 58-61
    • Galli, M.1
  • 10
    • 0037233820 scopus 로고    scopus 로고
    • Incidence of and risk factors for lipoatrophy (abnormal fat loss) in ambulatory HIV-1 infected patients
    • LICHTENSTEIN, K. et al. 2003. Incidence of and risk factors for lipoatrophy (abnormal fat loss) in ambulatory HIV-1 infected patients. J. Acquired Immune Defic. Syndr. 32: 48-56.
    • (2003) J. Acquired Immune Defic. Syndr. , vol.32 , pp. 48-56
    • Lichtenstein, K.1
  • 11
    • 0344197097 scopus 로고    scopus 로고
    • Incidence of lipoatrophy and lipohypertrophy in the Women's Interagency HIV Study
    • TIEN, P. et al. 2003. Incidence of lipoatrophy and lipohypertrophy in the Women's Interagency HIV Study. J. Acquired Immune Defic. Syndr. 34: 461-466.
    • (2003) J. Acquired Immune Defic. Syndr. , vol.34 , pp. 461-466
    • Tien, P.1
  • 12
    • 0035824745 scopus 로고    scopus 로고
    • Failure to maintain long-term adherence to highly active anti-retroviral therapy: The role of lipodystrophy
    • DURAN, S. et al. 2001. Failure to maintain long-term adherence to highly active anti-retroviral therapy: the role of lipodystrophy. AIDS 15: 2441-2444.
    • (2001) AIDS , vol.15 , pp. 2441-2444
    • Duran, S.1
  • 13
    • 0035119211 scopus 로고    scopus 로고
    • Self-reported symptoms after initiation of a protease inhibitor in HIV-infected patients and their impact on adherence to HAART
    • DURAN, S. et al. 2001. Self-reported symptoms after initiation of a protease inhibitor in HIV-infected patients and their impact on adherence to HAART. HIV Clin. Trials 2: 38-45.
    • (2001) HIV Clin. Trials , vol.2 , pp. 38-45
    • Duran, S.1
  • 14
    • 0037032941 scopus 로고    scopus 로고
    • Increased risk of lipoatrophy under stavudine in HIV-I infected patients: Results of a substudy from a comparative trial
    • JOLY, V. et al. 2002. Increased risk of lipoatrophy under stavudine in HIV-I infected patients: results of a substudy from a comparative trial. AIDS 16: 2447-2454.
    • (2002) AIDS , vol.16 , pp. 2447-2454
    • Joly, V.1
  • 15
    • 0345479155 scopus 로고    scopus 로고
    • Host factors may be more important than the choice of antiretrovirals in the development of lipoatrophy
    • MCCOMSEY, G. & J.F. MAA. 2003. Host factors may be more important than the choice of antiretrovirals in the development of lipoatrophy. AIDS Read 13: 539-559.
    • (2003) AIDS Read , vol.13 , pp. 539-559
    • McComsey, G.1    Maa, J.F.2
  • 16
    • 0032493043 scopus 로고    scopus 로고
    • A syndrome of peripheral lipodystrophy, hyperlipidaemia, and insulin resistance in patients receiving HIV protease inhibitors
    • CARR, A. et al. 1998. A syndrome of peripheral lipodystrophy, hyperlipidaemia, and insulin resistance in patients receiving HIV protease inhibitors. AIDS 12: F51-F58.
    • (1998) AIDS , vol.12
    • Carr, A.1
  • 17
    • 0036151417 scopus 로고    scopus 로고
    • Body habitus changes and metabolic alterations in protease inhibitor-naive HIV-1-infected patients treated with two nucleoside reverse transcriptase inhibitors
    • GALLI, M. et al. 2002. Body habitus changes and metabolic alterations in protease inhibitor-naive HIV-1-infected patients treated with two nucleoside reverse transcriptase inhibitors. J. Acquired Immune Defic. Syndr. 29: 21-31.
    • (2002) J. Acquired Immune Defic. Syndr. , vol.29 , pp. 21-31
    • Galli, M.1
  • 18
    • 0033391005 scopus 로고    scopus 로고
    • A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy
    • SAINT-MARC, T. et al. 1999. A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy. AIDS 13: 1659-1667.
    • (1999) AIDS , vol.13 , pp. 1659-1667
    • Saint-Marc, T.1
  • 19
    • 0033924871 scopus 로고    scopus 로고
    • Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection
    • MALLAL, S.A. et al. 2000. Contribution of nucleoside analogue reverse transcriptase inhibitors to subcutaneous fat wasting in patients with HIV infection. AIDS 14: 1309-1316.
    • (2000) AIDS , vol.14 , pp. 1309-1316
    • Mallal, S.A.1
  • 20
    • 0035964717 scopus 로고    scopus 로고
    • Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy
    • SHIKUMA, C.M. et al. 2001. Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy. AIDS 15: 1801-1809.
    • (2001) AIDS , vol.15 , pp. 1801-1809
    • Shikuma, C.M.1
  • 21
    • 0042732970 scopus 로고    scopus 로고
    • Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6, and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy
    • KANNISTO, K. et al. 2003. Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6, and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy. AIDS 17: 1753-1762.
    • (2003) AIDS , vol.17 , pp. 1753-1762
    • Kannisto, K.1
  • 22
    • 0042410593 scopus 로고    scopus 로고
    • Mitochondrial proliferation, DNA depletion, and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients
    • PACE, C.S. et al. 2003. Mitochondrial proliferation, DNA depletion, and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients. Antivir. Ther. 8: 323-331.
    • (2003) Antivir. Ther. , vol.8 , pp. 323-331
    • Pace, C.S.1
  • 23
    • 0042438992 scopus 로고    scopus 로고
    • Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy
    • DOMINGO, P. et al. 1999. Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy. AIDS 13: 2261-2267.
    • (1999) AIDS , vol.13 , pp. 2261-2267
    • Domingo, P.1
  • 24
    • 0041823260 scopus 로고    scopus 로고
    • Mitochondria and lipodystrophy: Where are we now?
    • GERSCHENSON, M. 2003. Mitochondria and lipodystrophy: where are we now? Antivir. Ther. 8: 261-263.
    • (2003) Antivir. Ther. , vol.8 , pp. 261-263
    • Gerschenson, M.1
  • 25
    • 0037055028 scopus 로고    scopus 로고
    • Abacavir substitution for nucleoside analogs in patients with HIV lipoatrophy: A randomized trial
    • CARR, A. et al. 2002. Abacavir substitution for nucleoside analogs in patients with HIV lipoatrophy: a randomized trial. JAMA 288: 207-215.
    • (2002) JAMA , vol.288 , pp. 207-215
    • Carr, A.1
  • 26
    • 0037032924 scopus 로고    scopus 로고
    • Thymidine analogue withdrawal for lipoatrophic patients on protease-sparing therapy improves lipoatrophy, but compromises antiviral control: The PIILR extension study
    • SMITH, D.E. et al. 2002. Thymidine analogue withdrawal for lipoatrophic patients on protease-sparing therapy improves lipoatrophy, but compromises antiviral control: the PIILR extension study. AIDS 16: 2489-2491.
    • (2002) AIDS , vol.16 , pp. 2489-2491
    • Smith, D.E.1
  • 27
    • 0034457359 scopus 로고    scopus 로고
    • Fasting hyperinsulinemia in human immunodeficiency virus-infected men: Relationship to body composition, gonadal function, and protease inhibitor use
    • HADIGAN, C. et al. 2000. Fasting hyperinsulinemia in human immunodeficiency virus-infected men: relationship to body composition, gonadal function, and protease inhibitor use. J. Clin. Endocrinol. Metab. 85: 35-41.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 35-41
    • Hadigan, C.1
  • 28
    • 0042262053 scopus 로고    scopus 로고
    • Effects of testosterone administration on fat distribution, insulin sensitivity, and atherosclerosis progression
    • BHASIN, S. 2003. Effects of testosterone administration on fat distribution, insulin sensitivity, and atherosclerosis progression. Clin. Infect. Dis. 37: S142-S149.
    • (2003) Clin. Infect. Dis. , vol.37
    • Bhasin, S.1
  • 29
    • 0036682588 scopus 로고    scopus 로고
    • Effect of recombinant human growth hormone in the treatment of visceral fat accumulation in HIV infection
    • ENGELSON, E.S. et al. 2002. Effect of recombinant human growth hormone in the treatment of visceral fat accumulation in HIV infection. J. Acquired Immune Defic. Syndr. 30: 379-391.
    • (2002) J. Acquired Immune Defic. Syndr. , vol.30 , pp. 379-391
    • Engelson, E.S.1
  • 30
    • 0036172410 scopus 로고    scopus 로고
    • Effects of recombinant human growth hormone on hepatic lipid and carbohydrate metabolism in HIV-infected patients with fat accumulation
    • SCHWARZ, J.M. et al. 2002. Effects of recombinant human growth hormone on hepatic lipid and carbohydrate metabolism in HIV-infected patients with fat accumulation. J. Clin. Endocrinol. Metab. 87: 942.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 942
    • Schwarz, J.M.1
  • 31
    • 0034457359 scopus 로고    scopus 로고
    • Fasting hyperinsulinemia in human immunodeficiency virus-infected men: Relationship to body composition, gonadal function, and protease inhibitor use
    • HADIGAN, C. et al. 2000. Fasting hyperinsulinemia in human immunodeficiency virus-infected men: relationship to body composition, gonadal function, and protease inhibitor use. J. Clin. Endocrinol. Metab. 85: 35-41.
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 35-41
    • Hadigan, C.1
  • 32
    • 0001893502 scopus 로고    scopus 로고
    • A pilot study for the use of pioglitazone in the treatment of highly active antiretroviral therapy lipodystrophy syndromes
    • CALMY, A., et al. 2001. A pilot study for the use of pioglitazone in the treatment of highly active antiretroviral therapy lipodystrophy syndromes. Antivir. Ther. 6: 32.
    • (2001) Antivir. Ther. , vol.6 , pp. 32
    • Calmy, A.1
  • 33
    • 0043157304 scopus 로고    scopus 로고
    • Rosiglitazone in the treatment of HAART-associated lipodystrophy - A randomized double-blind placebo-controlled study
    • SUTINEN, J. et al. 2003. Rosiglitazone in the treatment of HAART-associated lipodystrophy - a randomized double-blind placebo-controlled study. Antivir. Ther. 8: 199-207.
    • (2003) Antivir. Ther. , vol.8 , pp. 199-207
    • Sutinen, J.1
  • 34
    • 0036797087 scopus 로고    scopus 로고
    • Improved insulin sensitivity and body fat distribution in HIV-infected patients treated with rosiglitazone: A pilot study
    • GELATO, M.C. et al. 2002. Improved insulin sensitivity and body fat distribution in HIV-infected patients treated with rosiglitazone: a pilot study. J. Acquired Immune Defic. Syndr. 31: 163-170.
    • (2002) J. Acquired Immune Defic. Syndr. , vol.31 , pp. 163-170
    • Gelato, M.C.1
  • 35
    • 0032184874 scopus 로고    scopus 로고
    • L-Carnitine: Therapeutic applications of a conditionally-essential amino acid
    • KELLY, G.S. 1998. L-Carnitine: therapeutic applications of a conditionally-essential amino acid. Altern. Med. Rev. 3: 345-360.
    • (1998) Altern. Med. Rev. , vol.3 , pp. 345-360
    • Kelly, G.S.1
  • 36
    • 0033841244 scopus 로고    scopus 로고
    • Nutrients and HIV: Part three-N-acetylcysteine, alpha-lipoic acid, L-glutamine, and L-carnitine
    • PATRICK, L. 2000. Nutrients and HIV: part three-N-acetylcysteine, alpha-lipoic acid, L-glutamine, and L-carnitine. Altern. Med. Rev. 5: 290-305.
    • (2000) Altern. Med. Rev. , vol.5 , pp. 290-305
    • Patrick, L.1
  • 38
    • 0025336324 scopus 로고
    • Determination of L-carnitine in biological fluids and tissues
    • DEUFEL, T. 1990. Determination of L-carnitine in biological fluids and tissues. J. Clin. Chem. Clin. Biochem. 28: 307-311.
    • (1990) J. Clin. Chem. Clin. Biochem. , vol.28 , pp. 307-311
    • Deufel, T.1
  • 39
    • 0026580218 scopus 로고
    • Carnitine deficiency in AIDS patients
    • DE SIMONE, C. et al. 1992. Carnitine deficiency in AIDS patients. AIDS 6: 203-205.
    • (1992) AIDS , vol.6 , pp. 203-205
    • De Simone, C.1
  • 40
    • 18344406455 scopus 로고    scopus 로고
    • Effect of L-carnitine on human immunodeficiency virus-1-associated apoptosis: A pilot study
    • MORETTI, S. et al. 1998. Effect of L-carnitine on human immunodeficiency virus-1-associated apoptosis: a pilot study. Blood 91: 3817-3824.
    • (1998) Blood , vol.91 , pp. 3817-3824
    • Moretti, S.1
  • 41
    • 0032976918 scopus 로고    scopus 로고
    • Acetyl-L-carnitine administration increases insulin-like growth factor 1 levels in asymptomatic HIV-1-infected subjects: Correlation with its suppressive effect on lymphocyte apoptosis and ceramide generation
    • DI MARZIO, L. et al. 1999. Acetyl-L-carnitine administration increases insulin-like growth factor 1 levels in asymptomatic HIV-1-infected subjects: correlation with its suppressive effect on lymphocyte apoptosis and ceramide generation. Clin. Immunol. 92: 103-110.
    • (1999) Clin. Immunol. , vol.92 , pp. 103-110
    • Di Marzio, L.1
  • 42
    • 0031290516 scopus 로고    scopus 로고
    • Effect of acetyl-L-carnitine in the treatment of painful peripheral neuropathies in HIV+ patients
    • SCARPINI, E. et al. 1997. Effect of acetyl-L-carnitine in the treatment of painful peripheral neuropathies in HIV+ patients. J. Peripher. Nerv. Syst. 2: 250-252.
    • (1997) J. Peripher. Nerv. Syst. , vol.2 , pp. 250-252
    • Scarpini, E.1
  • 43
    • 0035834537 scopus 로고    scopus 로고
    • Plasma carnitine in HIV-associated neuropathy
    • SIMPSON, D.M. et al. 2001. Plasma carnitine in HIV-associated neuropathy. AIDS 15: 2207-2208.
    • (2001) AIDS , vol.15 , pp. 2207-2208
    • Simpson, D.M.1
  • 44
    • 0035876311 scopus 로고    scopus 로고
    • L-Carnitine for the treatment of highly active antiretroviral therapy-related hypertriglyceridemia in HIV-infected adults
    • LOIGNON, M. & E. TOMA. 2001. L-Carnitine for the treatment of highly active antiretroviral therapy-related hypertriglyceridemia in HIV-infected adults. AIDS 15: 1194-1195.
    • (2001) AIDS , vol.15 , pp. 1194-1195
    • Loignon, M.1    Toma, E.2
  • 45
    • 0028210728 scopus 로고
    • Carnitine depletion in peripheral blood mononuclear cells from patients with AIDS: Effect of oral carnitine
    • DE SIMONE, C. et al. 1994. Carnitine depletion in peripheral blood mononuclear cells from patients with AIDS: effect of oral carnitine. AIDS 8: 655-660.
    • (1994) AIDS , vol.8 , pp. 655-660
    • De Simone, C.1
  • 46
    • 0035198276 scopus 로고    scopus 로고
    • L-Carnitine in the treatment of HIV-associated lipodystrophy syndrome
    • MAUSS, S. & G. SCHMUTZ. 2001. L-Carnitine in the treatment of HIV-associated lipodystrophy syndrome. HIV Med. 2: 59-60.
    • (2001) HIV Med. , vol.2 , pp. 59-60
    • Mauss, S.1    Schmutz, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.