메뉴 건너뛰기




Volumn 54, Issue 12, 2004, Pages 857-867

Pharmacological characteristics of KP-102 (GHRP-2), a potent growth hormone-releasing peptide

Author keywords

CAS 158861 67 7; Growth hormone releasing peptide 2; Hypothalamus; KP 102, growth hormone releasing property, Pharmacology; Pituitary; Pralmorelin

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; GLUTAMATE SODIUM; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR DERIVATIVE; PRALMORELIN; PROLACTIN;

EID: 10644241631     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1297041     Document Type: Article
Times cited : (17)

References (44)
  • 2
    • 0013935767 scopus 로고
    • Plasma growth hormone concentration in the rat determined by radioimmunoassay: Influence of sex, pregnancy, lactation, anesthesia, hypophysectomy and extrasellar pituitary transplants
    • Schalch, D. S., Reichlin, S., Plasma growth hormone concentration in the rat determined by radioimmunoassay: influence of sex, pregnancy, lactation, anesthesia, hypophysectomy and extrasellar pituitary transplants. Endocrinology 79, 275 (1966)
    • (1966) Endocrinology , vol.79 , pp. 275
    • Schalch, D.S.1    Reichlin, S.2
  • 3
    • 0015044981 scopus 로고
    • Regulation of immunoreactive growth hormone secretion in male rats
    • Takahashi, K., Daughaday, W. H., Kipnis, D. M., Regulation of immunoreactive growth hormone secretion in male rats. Endocrinology 88, 909 (1971)
    • (1971) Endocrinology , vol.88 , pp. 909
    • Takahashi, K.1    Daughaday, W.H.2    Kipnis, D.M.3
  • 4
    • 0015309674 scopus 로고
    • Growth hormone and ACTH secretion: Evidence for an inverse relationship in rats
    • Kokka, N., Garcia, J. F., George, R. et al., Growth hormone and ACTH secretion: evidence for an inverse relationship in rats. Endocrinology 90, 735 (1972)
    • (1972) Endocrinology , vol.90 , pp. 735
    • Kokka, N.1    Garcia, J.F.2    George, R.3
  • 5
    • 0015547364 scopus 로고
    • Effect of stress and hypothalamic differentiation on the secrection of growth hormone in the rat
    • Collu, R., Jequier, J. C., Letarte, J. et al., Effect of stress and hypothalamic differentiation on the secrection of growth hormone in the rat. Neuroendocrinology 11, 183 (1973)
    • (1973) Neuroendocrinology , vol.11 , pp. 183
    • Collu, R.1    Jequier, J.C.2    Letarte, J.3
  • 6
    • 0015990021 scopus 로고
    • Effect of septal lesions on plasma levels of MSH, corticosterone, GH, and prolactin before and after exposure to novel environment: Role of MSH in the septal syndrome
    • Brown, G. M., Uhlir, I. V., Seggie, J. et al., Effect of septal lesions on plasma levels of MSH, corticosterone, GH, and prolactin before and after exposure to novel environment: role of MSH in the septal syndrome. Endocrinology 94, 593 (1974)
    • (1974) Endocrinology , vol.94 , pp. 593
    • Brown, G.M.1    Uhlir, I.V.2    Seggie, J.3
  • 7
    • 0021368643 scopus 로고
    • Conformational energy studies and in vitro and in vivo activity data on growth hormone-releasing peptides
    • Momany, F. A., Bowers, C. Y., Reynolds, G. A. et al., Conformational energy studies and in vitro and in vivo activity data on growth hormone-releasing peptides. Endocrinology 114, 1531 (1984)
    • (1984) Endocrinology , vol.114 , pp. 1531
    • Momany, F.A.1    Bowers, C.Y.2    Reynolds, G.A.3
  • 8
    • 0021322884 scopus 로고
    • On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone
    • Bowers, C. Y., Momany, F. A., Reynolds, G. A. et al., On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 114, 1537 (1984)
    • (1984) Endocrinology , vol.114 , pp. 1537
    • Bowers, C.Y.1    Momany, F.A.2    Reynolds, G.A.3
  • 9
    • 0027180817 scopus 로고
    • GH releasing peptides-structure and kinetics
    • Bowers, C. Y., GH releasing peptides-structure and kinetics. J. Pediatr. Endocrinol. 6, 21 (1993)
    • (1993) J. Pediatr. Endocrinol. , vol.6 , pp. 21
    • Bowers, C.Y.1
  • 10
    • 0029129652 scopus 로고
    • Design and biological activities of L-163,191 (MK-677): A potent, orally active growth hormone secretagogue
    • Patchett, A. A., Nargund, R. P., Tata, J. R. et al., Design and biological activities of L-163,191 (MK-677): a potent, orally active growth hormone secretagogue. Proc. Natl. Acad. Sci. USA 92, 7001 (1995)
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 7001
    • Patchett, A.A.1    Nargund, R.P.2    Tata, J.R.3
  • 11
    • 0032779234 scopus 로고    scopus 로고
    • Pharmacological characterization of a new oral GH secretagogue, NN 703
    • Hansen, B. S., Raun, K., Nielsen, K. K. et al., Pharmacological characterization of a new oral GH secretagogue, NN703. Eur. J. Endocrinol. 141, 180 (1999)
    • (1999) Eur. J. Endocrinol. , vol.141 , pp. 180
    • Hansen, B.S.1    Raun, K.2    Nielsen, K.K.3
  • 12
    • 0035079820 scopus 로고    scopus 로고
    • Preclinical pharmacology of CP-424,391, an orally active pyrazolinone-piperidine [correction of pyrazolidinone-piperidine] growth hormone secretagogue
    • Pan, L. C., Carpino, P. A., Lefker, B. A. et al., Preclinical pharmacology of CP-424,391, an orally active pyrazolinone-piperidine [correction of pyrazolidinone-piperidine] growth hormone secretagogue. Endocrine 14, 121 (2001)
    • (2001) Endocrine , vol.14 , pp. 121
    • Pan, L.C.1    Carpino, P.A.2    Lefker, B.A.3
  • 13
    • 9444246501 scopus 로고    scopus 로고
    • A receptor in pituitary and hypothalamus that functions in growth hormone release
    • Howard, A. D., Feighner, S. D., Cully, D. F. et al., A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273, 974 (1996)
    • (1996) Science , vol.273 , pp. 974
    • Howard, A.D.1    Feighner, S.D.2    Cully, D.F.3
  • 14
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima, M., Hosoda, H., Date, Y. et al., Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656 (1999)
    • (1999) Nature , vol.402 , pp. 656
    • Kojima, M.1    Hosoda, H.2    Date, Y.3
  • 15
    • 0034726741 scopus 로고    scopus 로고
    • Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats
    • Date, Y., Murakami, N., Kojima, M. et al., Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem. Biophys. Res. Commun. 275, 477 (2000)
    • (2000) Biochem. Biophys. Res. Commun. , vol.275 , pp. 477
    • Date, Y.1    Murakami, N.2    Kojima, M.3
  • 16
    • 0033711116 scopus 로고    scopus 로고
    • The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion
    • Wren, A. M., Small, C. J., Ward, H. L. et al., The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141, 4325 (2000)
    • (2000) Endocrinology , vol.141 , pp. 4325
    • Wren, A.M.1    Small, C.J.2    Ward, H.L.3
  • 17
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschõp, M., Smiley, D. L., Heiman, M. L., Ghrelin induces adiposity in rodents. Nature 407, 908 (2000)
    • (2000) Nature , vol.407 , pp. 908
    • Tschõp, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 18
    • 0025809717 scopus 로고
    • On the actions of the growth hormone-releasing hexapeptide, GHRP
    • Bowers, C. Y., Sartor, A. O., Reynolds, G. A. et al., On the actions of the growth hormone-releasing hexapeptide, GHRP. Endocrinology 128, 2027 (1991)
    • (1991) Endocrinology , vol.128 , pp. 2027
    • Bowers, C.Y.1    Sartor, A.O.2    Reynolds, G.A.3
  • 19
    • 0031979460 scopus 로고    scopus 로고
    • Orally active growth hormone secretagogues: State of the art and clinical perspectives
    • Ghigo, E., Arvat, E., Camanni, F., Orally active growth hormone secretagogues: state of the art and clinical perspectives. Ann. Med. 30, 159 (1998)
    • (1998) Ann. Med. , vol.30 , pp. 159
    • Ghigo, E.1    Arvat, E.2    Camanni, F.3
  • 20
    • 0036787457 scopus 로고    scopus 로고
    • The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats
    • Date, Y., Murakami, N., Toshinai, K. et al., The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123, 1120 (2002)
    • (2002) Gastroenterology , vol.123 , pp. 1120
    • Date, Y.1    Murakami, N.2    Toshinai, K.3
  • 21
    • 0028170866 scopus 로고
    • Effect of D-Ala-D-beta Nal-Ala-Trp-D-phe-Lys-NH2 (KP-102) on GH secretion in urethane-anesthetized rats
    • Sawada, H., Sugihara, H., Onose, H. et al., Effect of D-Ala-D-beta Nal-Ala-Trp-D-phe-Lys-NH2 (KP-102) on GH secretion in urethane-anesthetized rats. Regul. Pept. 53, 195 (1994)
    • (1994) Regul. Pept. , vol.53 , pp. 195
    • Sawada, H.1    Sugihara, H.2    Onose, H.3
  • 22
    • 0029117082 scopus 로고
    • GH responses to intravenous bolus infusions of GH releasing hormone and GH releasing peptide 2 separately and in combination in adult volunteers
    • Tiulpakov, A. N., Brock, C. G., Pringle, P. J. et al., GH responses to intravenous bolus infusions of GH releasing hormone and GH releasing peptide 2 separately and in combination in adult volunteers. Clin. Endocrinol. (Oxf.) 43, 347 (1995)
    • (1995) Clin. Endocrinol. (Oxf.) , vol.43 , pp. 347
    • Tiulpakov, A.N.1    Brock, C.G.2    Pringle, P.J.3
  • 23
    • 0030155430 scopus 로고    scopus 로고
    • Characteristics of growth hormone secretion responsiveness to growth hormone-releasing peptide-2 (GHRP-2 or KP-102) in calves
    • Roh, S. G., Matsunaga, N., Hidaka, S. et al., Characteristics of growth hormone secretion responsiveness to growth hormone-releasing peptide-2 (GHRP-2 or KP-102) in calves. Endocr. J. 43, 291 (1996)
    • (1996) Endocr. J. , vol.43 , pp. 291
    • Roh, S.G.1    Matsunaga, N.2    Hidaka, S.3
  • 24
    • 0030602806 scopus 로고    scopus 로고
    • Effects of the synthesized growth hormone releasing peptide, KP-102, on growth hormone release in sodium glutamate monohydrated-treated low growth rats
    • Nakagawa, T., Ukai, K., Ohyama, T. et al., Effects of the synthesized growth hormone releasing peptide, KP-102, on growth hormone release in sodium glutamate monohydrated-treated low growth rats. Life Sci. 59, 705 (1996)
    • (1996) Life Sci. , vol.59 , pp. 705
    • Nakagawa, T.1    Ukai, K.2    Ohyama, T.3
  • 25
    • 0022225355 scopus 로고
    • Growth hormone responses to multiple injections of a fragment of human growth hormone-releasing factor in conscious male and female rats
    • Clark, R. G., Robinson, I. C., Growth hormone responses to multiple injections of a fragment of human growth hormone-releasing factor in conscious male and female rats. J. Endocrinol. 106, 281 (1985)
    • (1985) J. Endocrinol. , vol.106 , pp. 281
    • Clark, R.G.1    Robinson, I.C.2
  • 27
    • 0027322753 scopus 로고
    • Stimulation of growth hormone release from rat primary pituitary cells by L-692,429, a novel non-peptidyl GH secretagogue
    • Cheng, K., Chan, W. W., Butler, B. et al., Stimulation of growth hormone release from rat primary pituitary cells by L-692,429, a novel non-peptidyl GH secretagogue. Endocrinology 132, 2729 (1993)
    • (1993) Endocrinology , vol.132 , pp. 2729
    • Cheng, K.1    Chan, W.W.2    Butler, B.3
  • 28
    • 0017253257 scopus 로고
    • Evidence for an endogenous ultradian rhythm governing growth hormone secretion in the rat
    • Tannenbaum, G. S., Martin, J. B., Evidence for an endogenous ultradian rhythm governing growth hormone secretion in the rat. Endocrinology 98, 562 (1976)
    • (1976) Endocrinology , vol.98 , pp. 562
    • Tannenbaum, G.S.1    Martin, J.B.2
  • 30
    • 0025482793 scopus 로고
    • Interplay of somatostatin and growth hormone-releasing hormone in genesis of episodic growth hormone secretion
    • Tannenbaum, G.S., Painson, J.C., Lapointe, M. et al., Interplay of somatostatin and growth hormone-releasing hormone in genesis of episodic growth hormone secretion. Metabolism 39 (Suppl.), 35 (1990)
    • (1990) Metabolism , vol.39 , Issue.SUPPL. , pp. 35
    • Tannenbaum, G.S.1    Painson, J.C.2    Lapointe, M.3
  • 31
    • 0017119179 scopus 로고
    • Antiserum to somatostatin prevents stress-induced inhibition of growth hormone secretion in the rat
    • Terry, L. C., Willoughby, J. O., Braseau, P et al., Antiserum to somatostatin prevents stress-induced inhibition of growth hormone secretion in the rat. Science 192, 565 (1976)
    • (1976) Science , vol.192 , pp. 565
    • Terry, L.C.1    Willoughby, J.O.2    Braseau, P.3
  • 32
    • 0018759132 scopus 로고
    • Immunoreactive somatostatin in rat hypophyseal portal blood: Effect of anesthetics
    • Chihara, K., Arimura, A., Serially A. V., Immunoreactive somatostatin in rat hypophyseal portal blood: effect of anesthetics. Endocrinology 104, 1434 (1979)
    • (1979) Endocrinology , vol.104 , pp. 1434
    • Chihara, K.1    Arimura, A.2    Serially, A.V.3
  • 33
    • 0015969751 scopus 로고
    • Studies on the mechanism of pentobarbital-induced GH release in the rat
    • Martin, J. B., Studies on the mechanism of pentobarbital-induced GH release in the rat. Neuroendocrinology 13, 339 (1974)
    • (1974) Neuroendocrinology , vol.13 , pp. 339
    • Martin, J.B.1
  • 34
    • 0021077695 scopus 로고
    • The absence of an age-related change in the pituitary response to growth hormone-releasing factor in rats
    • William, B., The absence of an age-related change in the pituitary response to growth hormone-releasing factor in rats. Neuroendocrinology 37, 463 (1983)
    • (1983) Neuroendocrinology , vol.37 , pp. 463
    • William, B.1
  • 35
    • 0024335194 scopus 로고
    • Growth hormone response induced by synthetic human growth hormone-releasing factor (1-44) in healthy dogs
    • Abribat, T., Regnier, A., Morre, M., Growth hormone response induced by synthetic human growth hormone-releasing factor (1-44) in healthy dogs. Zentralbl. Veterinärmed. A 36, 367 (1989)
    • (1989) Zentralbl. Veterinärmed. A , vol.36 , pp. 367
    • Abribat, T.1    Regnier, A.2    Morre, M.3
  • 36
    • 0027674207 scopus 로고
    • Measurements of serum pituitary hormones and dynamic tests to evaluate the pituitary functions
    • Nakai, T., Measurements of serum pituitary hormones and dynamic tests to evaluate the pituitary functions. Nippon Rinsho 51, 2667 (1993)
    • (1993) Nippon Rinsho , vol.51 , pp. 2667
    • Nakai, T.1
  • 37
    • 0025293153 scopus 로고
    • Morphological effects of somatostatin on rat somatotrophs previously activated by growth hormone-releasing factor
    • Shimada, O., Tosaka-Shimada, H., Ishikawa, H., Morphological effects of somatostatin on rat somatotrophs previously activated by growth hormone-releasing factor. Cell. Tissue Res. 261, 219 (1990)
    • (1990) Cell. Tissue Res. , vol.261 , pp. 219
    • Shimada, O.1    Tosaka-Shimada, H.2    Ishikawa, H.3
  • 38
    • 0029061494 scopus 로고
    • Growth hormone-releasing peptide-6 stimulated sleep, growth hormone, ACTH and cortisol release in normal man
    • Frieboes, R. M., Murck, H., Maier, P. et al., Growth hormone-releasing peptide-6 stimulated sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology 61, 584 (1995)
    • (1995) Neuroendocrinology , vol.61 , pp. 584
    • Frieboes, R.M.1    Murck, H.2    Maier, P.3
  • 39
    • 0030909925 scopus 로고    scopus 로고
    • Activation of the hypothalamo-pituitary-adrenal axis by the growth hormone (GH) secretagogue, GH-releasing peptide-6, in rats
    • Thomas, G. B., Fairhall, K. M., Robinson, I. C., Activation of the hypothalamo-pituitary-adrenal axis by the growth hormone (GH) secretagogue, GH-releasing peptide-6, in rats. Endocrinology 138, 1585 (1997)
    • (1997) Endocrinology , vol.138 , pp. 1585
    • Thomas, G.B.1    Fairhall, K.M.2    Robinson, I.C.3
  • 40
    • 0035083793 scopus 로고    scopus 로고
    • Biologic activities of growth hormone secretagogues in humans
    • Ghigo, E., Arvat, E., Giorolano, R. et al., Biologic activities of growth hormone secretagogues in humans. Endocrine 14, 87 (2001)
    • (2001) Endocrine , vol.14 , pp. 87
    • Ghigo, E.1    Arvat, E.2    Giorolano, R.3
  • 41
    • 0031253840 scopus 로고    scopus 로고
    • Mechanism of action of growth hormone-releasing peptide- 2 in bovine pituitary cells
    • Roh, S. G., He, M. L., Matsunaga, N. et al., Mechanism of action of growth hormone-releasing peptide-2 in bovine pituitary cells. J. Anim. Sci. 75, 2744 (1997)
    • (1997) J. Anim. Sci. , vol.75 , pp. 2744
    • Roh, S.G.1    He, M.L.2    Matsunaga, N.3
  • 42
    • 0027414444 scopus 로고
    • Systemic administration of growth hormone-releasing peptide (GHRP-6) activates hypothalamic arcuate neurons
    • Dickson, S. L., Leng, G., Robinson, I. C. A. F., Systemic administration of growth hormone-releasing peptide (GHRP-6) activates hypothalamic arcuate neurons. Neuroscience 53, 303 (1993)
    • (1993) Neuroscience , vol.53 , pp. 303
    • Dickson, S.L.1    Leng, G.2    Robinson, I.C.A.F.3
  • 43
    • 0032894675 scopus 로고    scopus 로고
    • An electro-physiological and morphological investigation of the projections of growth hormone-releasing peptide-6-responsive neurons in the rat arcuate nucleus to the median eminence and to the paraventricular nucleus
    • Honda, K., Bailey, A. R., Bull, P. M. et al., An electro-physiological and morphological investigation of the projections of growth hormone-releasing peptide-6-responsive neurons in the rat arcuate nucleus to the median eminence and to the paraventricular nucleus. Neuroscience 90, 875 (1999)
    • (1999) Neuroscience , vol.90 , pp. 875
    • Honda, K.1    Bailey, A.R.2    Bull, P.M.3
  • 44
    • 0030762351 scopus 로고    scopus 로고
    • Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues
    • Guan, X. M., Yu, H., Palyha, O. C. et al., Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res. Mol. Brain Res. 48, 23 (1997)
    • (1997) Brain Res. Mol. Brain Res. , vol.48 , pp. 23
    • Guan, X.M.1    Yu, H.2    Palyha, O.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.