Subacute toxicity and toxicokinetics of a new antibiotic, DW-224a, after single and 4-week repeated oral administration in dogs

Biological and Pharmaceutical Bulletin

Volumn 26, Issue 6, 2003, Pages 832-839

  Han, Junghee ^a   Kim, Jong Choon ^b   Chung, Moon Koo ^a   Kim, Byungbae ^c   Choi, Dong Rack ^d  

^a Korea Institute of Toxicology   (South Korea)

^b Chonnam National University   (South Korea)

^c Hong Ik University   (South Korea)

^d DongWha Pharm Ind Co   (South Korea)

Author keywords

4 week oral administration; Dog; DW 224a; Subacute toxicity; Toxicokinetics

Indexed keywords

1 CYCLOPROPYL 6 FLUORO 7 [8 (METHOXYIMINO) 2,6 DIAZASPIRO[3,4]OCT 6 YL] 4 OXO 1,4 DIHYDRO[1,8]NAPHTHYRIDINE 3 CARBOXYLIC ACID; ANTIBIOTIC AGENT; CHOLESTEROL; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BODY WEIGHT; CHEMICAL ANALYSIS; CHOLESTEROL BLOOD LEVEL; CLINICAL OBSERVATION; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ACCUMULATION; DRUG ADMINISTRATION ROUTE; DRUG BLOOD LEVEL; DRUG SCREENING; FEMALE; FOOD INTAKE; HEMATOLOGY; HEMOCONCENTRATION; HISTOPATHOLOGY; MALE; MORTALITY; NONHUMAN; ORGAN WEIGHT; PARAMETER; SALIVATION; SERUM; SEX DIFFERENCE; TARGET ORGAN; TESTIS ATROPHY; THYMUS ATROPHY; TIME; TOXICITY; TOXICOKINETICS; URINALYSIS; VOMITING;

EID: 10644240819     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.26.832     Document Type: Article

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