Using a small molecule inhibitor of peptide: N-glycanaseto probe its role in glycoprotein turnover

Chemistry and Biology

Volumn 11, Issue 12, 2004, Pages 1677-1687

  Misaghi, Shahram ^a   Pacold, Michael E ^a   Blom, Daniël ^a   Ploegh, Hidde L ^a   Korbel, Gregory Alan ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASPASE; GLYCOPEPTIDASE; GLYCOPROTEIN; HLA ANTIGEN CLASS 1; LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE CHLOROMETHYL KETONE; Z VAL ALA ASP(OME) FLUOROMETHYLKETONE; Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE;

ANIMAL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; BINDING SITES; CASPASES; CELL LINE, TUMOR; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; GLYCOPROTEINS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MICE; MOLECULAR STRUCTURE; PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL) ASPARAGINE AMIDASE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA;

EID: 10644226176     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2004.11.010     Document Type: Article

References (33)

1. L. Ellgaard, M. Molinari, and A. Helenius Setting the standards: quality control in the secretory pathway Science 286 1999 1882 1888
2. L. Ellgaard, and A. Helenius ER quality control: towards an understanding at the molecular level Curr. Opin. Cell Biol. 13 2001 431 437
3. L. Ellgaard, and A. Helenius Quality control in the endoplasmic reticulum Nat. Rev. Mol. Cell Biol. 4 2003 181 191
4. R.E. Dempski Jr., and B. Imperiali Oligosaccharyl transferase: gatekeeper to the secretory pathway Curr. Opin. Chem. Biol. 6 2002 844 850
5. P.A. Wearsch, C.A. Jakob, A. Vallin, R.A. Dwek, P.M. Rudd, and P. Cresswell Major histocompatibility complex class I molecules expressed with monoglucosylated N-linked glycans bind calreticulin independently of their assembly status J. Biol. Chem. 279 2004 25112 25121
6. D. Blom, C. Hirsch, P. Stern, D. Tortorella, and H.L. Ploegh A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised EMBO J. 23 2004 650 658
7. C. Hirsch, S. Misaghi, D. Blom, M.E. Pacold, and H.L. Ploegh Yeast N-glycanase distinguishes between native and non-native glycoproteins EMBO Rep. 5 2004 201 206
8. T.H. Plummer Jr., J.H. Elder, S. Alexander, A.W. Phelan, and A.L. Tarentino Demonstration of peptide:N-glycosidase F activity in endo-beta-N-acetylglucosaminidase F preparations J. Biol. Chem. 259 1984 10700 10704
9. H. Park, T. Suzuki, and W.J. Lennarz Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation Proc. Natl. Acad. Sci. USA 98 2001 11163 11168
10. T. Suzuki, H. Park, N.M. Hollingsworth, R. Sternglanz, and W.J. Lennarz PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase J. Cell Biol. 149 2000 1039 1052
11. C. Hirsch, D. Blom, and H.L. Ploegh A role for N-glycanase in the cytosolic turnover of glycoproteins EMBO J. 22 2003 1036 1046
12. M.T. Heemels, and H. Ploegh Generation, translocation, and presentation of MHC class I-restricted peptides Annu. Rev. Biochem. 64 1995 463 491
13. M.H. Furman, H.L. Ploegh, and D. Tortorella Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules J. Biol. Chem. 277 2002 3258 3267
14. B.N. Lilley, and H.L. Ploegh A membrane protein required for dislocation of misfolded proteins from the ER Nature 429 2004 834 840
15. E.J. Wiertz, D. Tortorella, M. Bogyo, J. Yu, W. Mothes, T.R. Jones, T.A. Rapoport, and H.L. Ploegh Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction Nature 384 1996 432 438
16. E.J. Wiertz, T.R. Jones, L. Sun, M. Bogyo, H.J. Geuze, and H.L. Ploegh The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol Cell 84 1996 769 779
17. M. Garcia-Calvo, E.P. Peterson, B. Leiting, R. Ruel, D.W. Nicholson, and N.A. Thornberry Inhibition of human caspases by peptide-based and macromolecular inhibitors J. Biol. Chem. 273 1998 32608 32613
18. S. Katiyar, T. Suzuki, B.J. Balgobin, and W.J. Lennarz Site-directed mutagenesis study of yeast peptide:N-glycanase. Insight into the reaction mechanism of deglycosylation J. Biol. Chem. 277 2002 12953 12959
19. R.D. Klausner, J. Lippincott-Schwartz, and J.S. Bonifacino The T cell antigen receptor: insights into organelle biology Annu. Rev. Cell Biol. 6 1990 403 431
20. H. Yu, G. Kaung, S. Kobayashi, and R.R. Kopito Cytosolic degradation of T-cell receptor alpha chains by the proteasome J. Biol. Chem. 272 1997 20800 20804
21. J.B. Huppa, and H.L. Ploegh The alpha chain of the T cell antigen receptor is degraded in the cytosol Immunity 7 1997 113 122
22. J.C. Powers, J.L. Asgian, O.D. Ekici, and K.E. James Irreversible inhibitors of serine, cysteine, and threonine proteases Chem. Rev. 102 2002 4639 4750
23. T.M. Caserta, A.N. Smith, A.D. Gultice, M.A. Reedy, and T.L. Brown Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties Apoptosis 8 2003 345 352
24. R.G. Spiro Role of N-linked polymannose oligosaccharides in targeting glycoproteins for endoplasmic reticulum-associated degradation Cell. Mol. Life Sci. 61 2004 1025 1041
25. T. Suzuki, H. Park, K. Kitajima, and W.J. Lennarz Peptides glycosylated in the endoplasmic reticulum of yeast are subsequently deglycosylated by a soluble peptide: N-glycanase activity J. Biol. Chem. 273 1998 21526 21530
26. S. Weng, and R.G. Spiro Demonstration of a peptide:N-glycosidase in the endoplasmic reticulum of rat liver Biochem. J. 322 1997 655 661
27. Y. Ye, Y. Shibata, C. Yun, D. Ron, and T.A. Rapoport A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol Nature 429 2004 841 847
28. D. Tortorella, C.M. Story, J.B. Huppa, E.J. Wiertz, T.R. Jones, I. Bacik, J.R. Bennink, J.W. Yewdell, and H.L. Ploegh Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential J. Cell Biol. 142 1998 365 376
29. F. Hochstenbach, V. David, S. Watkins, and M.B. Brenner Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly Proc. Natl. Acad. Sci. USA 89 1992 4734 4738
30. K. Takegawa, K. Yamabe, K. Fujita, M. Tabuchi, M. Mita, H. Izu, A. Watanabe, Y. Asada, M. Sano, and A. Kondo Cloning, sequencing, and expression of Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase in Escherichia coli Arch. Biochem. Biophys. 338 1997 22 28
31. A. Rehm, P. Stern, H.L. Ploegh, and D. Tortorella Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor EMBO J. 20 2001 1573 1582
32. E. Ponnusamy, U. Fotadar, A. Spisni, and D. Fiat A novel method for the rapid, nonaqueous tert-butoxycarbonylation of some O-17-labeled amino-acids and O-17-NMR parameters of the products Synthesis (Stuttgart) 1 1986 48 49
33. Palmer, J.T. May 1993. Process for forming a fluoromethyl ketone. U.S. patent 5,210,272.