Glial cell line-derived neurotrophic factor (GDNF) gene expression in the human brain: A post mortem in situ hybridization study with special reference to Parkinson's disease

Journal of Neural Transmission

Volumn 103, Issue 8-9, 1996, Pages 1043-1052

  Hunot, S ^a   Bernard, V ^a,b   Faucheux, B ^a   Boissiere F ^a   Leguern, E ^a   Brana, C ^b   Gautris, P P ^c   Guerin J ^c   Bloch, B ^b   Agid, Y ^a   Hirsch, E C ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b CNRS   (France)

^c HÔPITAL PELLEGRIN   (France)

Author keywords

Adult; Cell death; GDNF; In situ hybridization; Newborn infant; Parkinson's disease

Indexed keywords

NEUROTROPHIC FACTOR;

AGED; ARTICLE; ASTROCYTOMA; AUTOPSY; BRAIN; CELL DEATH; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; GENE EXPRESSION; GLIA CELL; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MESENCEPHALON; METHODOLOGY; NERVE CELL DEGENERATION; PARKINSON DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA PROBE; STAINING; TISSUE SECTION;

AGED; AGED, 80 AND OVER; BRAIN; CASE-CONTROL STUDIES; CELL DEATH; GENE EXPRESSION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; IN SITU HYBRIDIZATION; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; PARKINSON DISEASE;

EID: 10544242965     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01291789     Document Type: Article

References (43)

1. Agid Y, Ruherg M, Javoy-Agid F, Hirsch EC, Raisman-Vozari R, Vyas S, Faucheux B, Michel P, Kastner A, Blanchard V, Damier P, Villares J, Zhang P (1993) Are dopaminergic neurons selectively vulnerable to Parkinson's disease? In: Narabayashi H, Nagatsu T, Yanagisawa N, Mizuno Y (eds) Advances in neurology, vol 60. Raven Press, New York, pp 148-164
2. Alexi T, Hefti F (1993) Trophic actions of transforming growth factor α on mesencephalic dopaminergic neurons developing in culture. Neuroscience 55: 903-918
3. Altar CA, Boylan CB, Fritsche M, Jones BE, Jackson C, Wiegand SJ, Lindsay RM, Hyman C (1994) Efficacy of brain-derived neurotrophic factor and neurotrophin-3 on neurochemical and behavioral deficits associated with partial nigrostriatal dopamine lesions. J Neurochem 63: 1021-1032
4. Anglade P, Blanchard V, Raisman-Vozari R, Faucheux B, Herrero MT, Obeso JA, Mouatt-Prigent A, Kastner A, Strada O, Javoy-Agid F, Agid Y, Hirsch EC (1996) Is dopaminergic cell death accompanied by concomitant nerve plasticity? In: Battistin L, Scarlato G, Caraceni T, Ruggieri S (eds) Advances in neurology, vol 69. Lippincott Raven Publishers, Philadelphia, pp 195-208
5. Beck K, Knüsel B, Hefti F (1993) The nature of the trophic action of brain-derived neurotrophic factor, des(1-3)-insulin-like growth factor-1, and basic fibroblast growth factor on mesencephalic dopaminergic neurons developing in culture. Neuroscience 52: 855-866
6. Beck KD, Valverde J, Alexi T, Poulsen K, Moffat B, Vandlen RA, Rosenthal A, Hefti F (1995) Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373: 339-341
7. Bernard V, Gardiol A, Faucheux B, Bloch B, Agid Y, Hirsch EC (1996) Expression of glutamate receptors in the human and rat basal ganglia: effect of the dopaminergic denervation on AMPA receptor gene expression in the sriatopallidal complex in Parkinson's disease and rat with 6-OHDA lesion. J Comp Neurol 368: 553-568
8. Bernheimer H, Birkmayer W, Hornykiewicz, O, Jellinger K, Seitelberger F (1973) Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci 20: 415-455
9. Blum M, Weickert CS (1995) GDNF mRNA expression in normal postnatal development, aging, and in Weaver mutant mice. Neurobiol Aging 16: 925-929
10. Bowenkamp KE, Huffman AF, Gerhardt GA, Henry MA, Biddle PT, Hoffer BJ, Granholm A-CE (1995) Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. J Comp Neurol 355: 479-489
11. Brana C, Charron G, Aubert I, Carles D, Martin-Negrier ML, Fournier MC, Vital C, Bloch B (1995) Ontogeny of the striatal neurons expressing neuropeptide genes in the human fetus and neonate. J Comp Neurol 360: 2-19
12. 11C raclopride and positron emission tomography. Ann Neurol 31: 184-192
13. Cristina N, Chatellard-Causse C, Manier M, Feuerstein C (1995) GDNF: existence of a second transcript in the brain. Mol Brain Res 32: 354-357
14. Damier P, Hirsch EC, Zhang P, Agid Y, Javoy-Agid F (1993) Glutathione peroxidase, glial cells and Parkinson's disease. Neuroscience 52: 1-6
15. Hadjiconstantinou M, Fitkin JG, Dalia A, Neff NH (1991) Epidermal growth factor enhances striatal dopaminergic parameters in the 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine-treated mouse. J Neurochem 57: 479-482
16. Hagg T, Varon S (1993) Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. Proc Natl Acad Sci USA 90: 6315-6319
17. Humpel C, Hoffer B, Strömberg I, Bektesh S, Collins F, Oison L (1994) Neurons of the hippocampal formation express glial cell line-derived neurotrophic factor messenger RNA in response to kainate-induced excitation. Neuroscience 59: 791-795
18. Hyman C, Juhasz M, Jackson C, Wright P, Ip NY, Lindsay M (1994) Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. J Neurosci 14: 335-347
19. Knüsel B, Michel PP, Schwaber JS, Hefti F (1990) Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast factor, epidermal growth factor, insulin, and insulin-like growth factor I and II. J Neurosci 10: 558-570
20. Krieglstein K, Suter-Crazzolara C, Fischer WH, Unsicker K (1995) TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity. EMBO J 14: 736-742
21. 67 mRNA. Eur J Neurosci 7: 1199-1209
22. Levy R, Vila M, Herrero MT, Faucheux B, Agid Y, Hirsch EC (1995b) Striatal expression of substance P and methionin-enkephalin genes in patients with Parkinson's disease. Neurosci Lett 199: 220-224
23. Lin L-F H, Doherty DH, Lile JD, Bektesh S, Collins F (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260: 1130-1132
24. Mayer E, Dunnett SB, Pellitteri R, Fawcett JW (1993) Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons. I. Effects in vitro. Neuroscience 56: 379-388
25. Murray KD, Gall CM, Jones EG, Isackson PJ (1994) Differential regulation of brainderived neurotrophic factor and type II calcium/calmoduline-dependent protein kinase messenger RNA expression in Alzheimer's disease. Neuroscience 60: 37-48
26. Olson L, Humpel C, Strömberg I, Hoffer B, Collins F (1993) Brain sites of glial-cell-line derived neurotrophic factor synthesis as revealed by in situ hybridization. Soc Neurosci Abstr 19: 652
27. Otto D, Unsicker K (1990) Basic FGF reverses chemical and morphological deficits in the nigrostriatal system of MPTP-treated mice. J Neurosci 10: 1912-1921
28. Otto D, Unsicker K (1993) FGF-2-mediated protection of cultured mesencephalic dopaminergic neurons against MPTP and MPP+: specificity and impact of culture conditions, non-dopaminergic neurons, and astroglial cells. J Neurosci Res 34: 382-393
29. Phillips HS, Hains JM, Armanini M, Laramee GR, Johson SA, Winslow JW (1991) BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 7: 695-702
30. Poulsen KT, Armanini MP, Klein RD, Hynes MA, Phillips HS, Rosenthal A (1994) TGFβ2 and TGFβ3 are potent survival factors for midbrain dopaminergic neurons. Neuron 13: 1245-1252
31. Represa A, Niquet J, Pollard H, Ben-Ari Y (1995) Cell death, gliosis, and synaptic remodeling in the hippocampus of epileptic rats. J Neurobiol 26: 413-425
32. Schaar DG, Sieber B-A, Dreyfus CF, Black I (1993) Regional and cell-specific expression of GDNF in rat brain. Exp Neurol 124: 368-371
33. Schmidt-Kastner R, Tomac A, Hoffer B, Bektesh S, Rosenzweig B, Olson L (1994) Glial cell-line derived neurotrophic factor (GDNF) mRNA upregulation in striatum and cortical areas after pilocarpine-induced status epilepticus in rats. Mol Brain Res 26: 325-330
34. Scott SA, Mufson EJ, Weingartner JA, Skau KA, Crutcher KA (1995) Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J Neurosci 15: 6213-6221
35. Springer JE, Mu X, Bergmann LW, Trojanowski JQ (1994) Expression of GDNF mRNA in rat and human nervous tissue. Exp Neurol 127: 167-170
36. Springer JE, Seeburger JL, He J, Gabrea A, Blankenhorn EP, Bergman LW (1995) cDNA sequence and differential mRNA regulation of two forms of glial cell line-derived neurotrophic factor in Schwann cells and rat skeletal muscle. Exp Neurol 131: 47-52
37. Strömberg I, Björklund L, Johanson M, Tomac A, Collins F, Olson L, Hoffer B, Humpel C (1993) Glial cell line-derived neurotrophic factor is expressed in the developing but not adult striatum and stimulates developing dopamine neurons in vivo. Exp Neurol 124: 401-412
38. Studer L, Spenger C, Seiler RW, Altar CA, Lindsay RM, Hyman C (1995) Comparison of the effects of the neurotrophins on the morphological structure of dopaminergic neurons in cultures of rats substantia nigra. Eur J Neurosci 7: 223-233
39. Suter-Crazzolara C, Unsicker K (1994) GDNF is expressed in two forms in many tissues outside the CNS. NeuroReport 5: 2486-2488
40. Tomac A, Lindqvist E, Lin L-F H, Ögren SO, Young D, Hoffer BJ, Olson L (1995) Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373: 335-339
41. Treanor J, Hefti F, Siegel M, Beck K (1995) Characterization of GDNF binding to putative GDNF receptor. Soc Neurosci Abstr 21: 1301
42. Unsicker K (1994) Growth factors in Parkinson's disease. Prog Growth Factor Res 5: 73-87
43. Vila M, Herrero MT, Levy R, Faucheux B, Ruberg M, Guillen J, Luquin MR, Guridi J, Javoy-Agid F, Agid Y, Obeso JA, Hirsch EC (1996) Consequences of nigrostriatal denervation on the γ-aminobutyric acidic neurons of substantia nigra pars reticulata and superior colliculus in parkinsonian syndromes. Neurology 46: 802-809