Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: Structure-activity relationship at N-methyl-D-aspartate receptor glycine sites

Journal of Medicinal Chemistry

Volumn 39, Issue 23, 1996, Pages 4643-4653

  Guzikowski, Anthony P ^c   Cai, Sui Xiong ^a   Espitia, Stephen A ^a   Hawkinson, Jon E ^a   Huettner, James E ^b   Nogales, Daniel F ^c   Tran, Minhtam ^a   Woodward, Richard M ^a   Weber, Eckard ^a   Keana, John F W ^c  

^a Department of Pharmacokinetics and Drug Metabolism   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF OREGON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,7 DICHLOROKYNURENIC ACID; BENZAZEPINE DERIVATIVE; DIZOCILPINE; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL CELL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; AROMATIZATION; ARTICLE; BINDING SITE; CONTROLLED STUDY; DEMETHYLATION; DRUG ELIMINATION; DRUG POTENCY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; OOCYTE; RAT; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; XENOPUS;

ANIMALS; BENZAZEPINES; DIZOCILPINE MALEATE; ELECTRIC STIMULATION; GLYCINE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; NEURONS; RADIOLIGAND ASSAY; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM; XENOPUS;

EID: 10544233783     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960479z     Document Type: Article

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