Diethylstilbestrol exposure during fetal development affects thymus: Studies in fourteen-month-old mice

Journal of Reproductive Immunology

Volumn 64, Issue 1-2, 2004, Pages 75-90

  Fenaux, J B ^a   Gogal Jr , R M ^a,b   Ahmed, S Ansar ^a  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^b Blacksburg VA 24060 USA ^*  (United States)

Author keywords

Apoptosis; Diethylstilbestrol (DES); Gender; Prenatal; Thymus

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DIETHYLSTILBESTROL;

ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CELL DISRUPTION; CONTROLLED STUDY; FEMALE; FETUS DEVELOPMENT; MALE; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; THYMOCYTE; THYMUS; UTERUS;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DIETHYLSTILBESTROL; ESTROGENS, NON-STEROIDAL; FEMALE; INJECTIONS, SUBCUTANEOUS; MALE; MICE; ORGAN SIZE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SEX FACTORS; T-LYMPHOCYTES; THYMUS GLAND;

EID: 10444243404     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2004.08.003     Document Type: Article

References (29)

1. S.A. Ahmed The immune system as a potential target for environmental estrogens (endocrine disrupters): a new emerging field Toxicology 150 2000 191 206
2. S.A. Ahmed, R.M. Gogal Jr., and J.E. Walsh A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay J. Immunol. Methods 170 1994 211 224
3. S.A. Ahmed, and N. Talal M.E. Kammuller N. Bloksma W. Seinen Auto-immunity and Toxicology 1989 Elsevier Science Publishers Holand 415
4. J. Calemine, R. Gogal, A. Lengi, P. Sponenberg, and S. Ahmed Immunomodulation by diethylstilbestrol is dose and gender related: effects on thymocyte apoptosis and mitogen-induced proliferation Toxicology 178 2002 101
5. K.J. Donner, K.M. Becker, B.D. Hissong, and S.A. Ahmed Comparison of multiple assays for kinetic detection of apoptosis in thymocytes exposed to dexamethasone or diethylstilbesterol Cytometry 35 1999 80 90
6. J.G. Forsberg Neonatal estrogen treatment and its consequences for thymus development, serum level of autoantibodies to cardiolipin, and the delayed-type hypersensitivity response J. Toxicol. Environ. Health A 60 2000 185 213
7. R.M. Gogal Jr., B.J. Smith, J. Kalnitsky, and S.D. Holladay Analysis of apoptosis of lymphoid cells in fish exposed to immunotoxic compounds Cytometry 39 2000 310 318
8. R.J. Golden, K.L. Noller, L. Titus-Ernstoff, R.H. Kaufman, R. Mittendorf, R. Stillman, and E.A. Reese Environmental endocrine modulators and human health: an assessment of the biological evidence Crit. Rev. Toxicol. 28 1998 109 227
9. K.A. Gould, J.D. Shull, and J. Gorski DES action in the thymus: inhibition of cell proliferation and genetic variation Mol. Cell Endocrinol. 170 2000 31 39
10. W.J. Hendry 3rd, X. Zheng, W.W. Leavitt, W.S. Branham, and D.M. Sheehan Endometrial hyperplasia and apoptosis following neonatal diethylstilbestrol exposure and subsequent estrogen stimulation in both host and transplanted hamster uteri Cancer Res. 57 1997 1903 1908
11. A.L. Herbst, H. Ulfelder, and D.C. Poskanzer Adenocarcinoma of the vagina Association of maternal stilbestrol therapy with tumor appearance in young women N. Engl. J. Med. 284 1971 878 881
12. S.D. Holladay, B.L. Blaylock, C.E. Comment, J.J. Heindel, W.M. Fox, K.S. Korach, and M.I. Luster Selective prothymocyte targeting by prenatal diethylstilbesterol exposure Cell Immunol. 152 1993 131 142
13. K. Kamiya, T. Sato, N. Nishimura, Y. Goto, K. Kano, and T. Iguchi Expression of estrogen receptor and proto-oncogene messenger ribonucleic acids in reproductive tracts of neonatally diethylstilbestrol-exposed female mice with or without post-puberal estrogen administration Exp. Clin. Endocrinol. Diabetes 104 1996 111 122
14. E. Karpuzoglu-Sahin, B.D. Hissong, and S. Ansar Ahmed Interferon-gamma levels are upregulated by 17-beta-estradiol and diethylstilbestrol J. Reprod. Immunol. 52 2001 113 127
15. E. Karpuzoglu-Sahin, Y. Zhi-Jun, A. Lengi, N. Sriranganathan, and S. Ansar Ahmed Effects of long-term estrogen treatment on ifn-gamma, il-2 and il-4 gene expression and protein synthesis in spleen and thymus of normal c57bl/6 mice Cytokine 14 2001 208 217
16. S.L. Klein, A.B. Wisniewski, A.L. Marson, G.E. Glass, and J.P. Gearhart Early exposure to genistein exerts long-lasting effects on the endocrine and immune systems in rats Mol. Med. 8 2002 742 749
17. Y. Kuniyasu, T. Takahashi, M. Itoh, J. Shimizu, G. Toda, and S. Sakaguchi Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation Int. Immunol. 12 2000 1145 1155
18. Z.W. Lai, N.C. Fiore, P.J. Hahn, T.A. Gasiewicz, and A.E. Silverstone Differential effects of diethylstilbestrol and 2,3,7,8- tetrachlorodibenzo-p- dioxin on thymocyte differentiation, proliferation, and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture Toxicol. Appl. Pharmacol. 168 2000 15 24
19. M. Lenter, and T. Bishop Experimental Design and Analysis 1993 Valley Book Company Blacksburg, VA 223
20. M. Marselos, and L. Tomatis Diethylstilboestrol: I, pharmacology, toxicology and carcinogenicity in humans Eur. J. Cancer. 1992 1182 1189
21. R.R. Newbold, B.C. Bullock, and J.A. McLachlan Uterine adenocarcinoma in mice following developmental treatment with estrogens: a model for hormonal carcinogenesis Cancer Res. 50 1990 7677 7681
22. R.R. Newbold, and J.A. McLachlan Vaginal adenosis and adenocarcinoma in mice exposed prenatally or neonatally to diethylstilbestrol Cancer Res. 42 1982 2003 2011
23. I. Schmid, C.H. Uittenbogaart, B. Keld, and J.V. Giorgi A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry J. Immunol. Methods 170 1994 145 157
24. E.M. Shevach CD4+ CD25+ suppressor T cells: more questions than answers Nat. Rev. Immunol. 2 2002 389 400
25. B.J. Smith, and S.D. Holladay Immune alterations in geriatric mice dosed subacutely with diethylstilbestrol (DES) J. Appl. Toxicol. 17 1997 265 271
26. E. Suri-Payer, A.Z. Amar, A.M. Thornton, and E.M. Shevach CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells J. Immunol. 160 1998 1212 1218
27. A.N. Tchernitchin, N.N. Tchernitchin, M.A. Mena, C. Unda, and J. Soto Imprinting: perinatal exposures cause the development of diseases during the adult age Acta Biol. Hung. 50 1999 425 440
28. D.I. Verthelyi, and S.A. Ahmed Estrogen increases the number of plasma cells and enhances their autoantibody production in nonautoimmune C57BL/6 mice Cell Immunol. 189 1998 125 134
29. S. Yellayi, C. Teuscher, J.A. Woods, T.H. Welsh Jr., K.S. Tung, M. Nakai, C.S. Rosenfeld, D.B. Lubahn, and P.S. Cooke Normal development of thymus in male and female mice requires estrogen/estrogen receptor-alpha signaling pathway Endocrine 12 2000 207 213