Improved immune responses to influenza vaccination in the elderly using an immunostimulant patch

Vaccine

Volumn 23, Issue 7, 2005, Pages 946-950

  Frech, Sarah A ^a   Kenney, Richard T ^a   Spyr, Christian A ^b   Lazar, Hedvika ^b   Viret, Jean François ^b   Herzog, Christian ^b   Glück, Reinhard ^b   Glenn, Gregory M ^a  

^a IOMAI Corporation   (United States)

^b Berna Biotech AG   (Switzerland)

Author keywords

Adjuvant; Elderly; Immunostimulant patch; Influenza; LT

Indexed keywords

ESCHERICHIA COLI ENTEROTOXIN; INFLUENZA VACCINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HEMAGGLUTINATION; HUMAN; IMMUNE RESPONSE; IMMUNOSTIMULATION; INFLUENZA; INFLUENZA VACCINATION; LANGERHANS CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PRURITUS; RASH; SEROCONVERSION; SIDE EFFECT;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, CUTANEOUS; ADOLESCENT; ADULT; AGED; BACTERIAL TOXINS; ENTEROTOXINS; ESCHERICHIA COLI PROTEINS; FEMALE; HUMANS; INFLUENZA VACCINES; INFLUENZA, HUMAN; MALE; MIDDLE AGED;

EID: 10444228872     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2004.06.036     Document Type: Article

References (22)

1. E. Crocetti, S. Arniani, F. Bordoni, G. Maciocco, M. Zappa, and E. Buiatti Effectiveness of influenza vaccination in the elderly in a community in Italy Eur. J. Epidemiol. 17 2 2001 163 168
2. K.L. Nichol, and M. Goodman Cost effectiveness of influenza vaccination for healthy persons between ages 65 and 74 years Vaccine 20 Suppl. 2 2002 21 24
3. E. Bernstein, D. Kaye, E. Abrutyn, P. Gross, M. Dorfman, and D.M. Murasko Immune response to influenza vaccination in a large healthy elderly population Vaccine 17 1 1999 82 94
4. I.A. de Bruijn, E.J. Remarque, C.M. Jol-van der Zijde, M.J. van Tol, R.G. Westendorp, and D.L. Knook Quality and quantity of the humoral immune response in healthy elderly and young subjects after annually repeated influenza vaccination J. Infect. Dis. 179 1 1999 31 36
5. P.A. Gross, A.W. Hermogenes, H.S. Sacks, J. Lau, and R.A. Levandowski The efficacy of influenza vaccine in elderly persons. A meta-analysis and review of the literature Ann. Intern. Med. 123 7 1995 518 527
6. EMEA. CPMP note for guidance on harmonisation of requirements for influenza vaccines. London: The European Agency for the Evaluation of Medicinal Products, Human Medicines Evaluation Unit; 1997. p. 1-18.
7. J. Olsson, A. Wikby, B. Johansson, S. Lofgren, B.O. Nilsson, and F.G. Ferguson Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study Mech. Ageing Dev. 121 1-3 2000 187 201
8. R.T. Kenney, and R. Edelman Survey of human-use adjuvants Expert Rev. Vaccines 2 2 2003 167 188
9. V. Baldo, T. Menegon, C. Bonello, A. Floreani, R. Trivello, and G. Collaborative Comparison of three different influenza vaccines in institutionalised elderly Vaccine 19 25-26 2001 3472 3475
10. F. Pregliasco, C. Mensi, W. Serpilli, L. Speccher, P. Masella, and A. Belloni Immunogenicity and safety of three commercial influenza vaccines in institutionalized elderly Aging (Milano) 13 1 2001 38 43
11. R. Glück, R. Mischler, B. Finkel, J.U. Que, B. Scarpa, and S.J. Cryz Jr. Immunogenicity of new virosome influenza vaccine in elderly people Lancet 344 8916 1994 160 163
12. M. Guebre-Xabier, S.A. Hammond, D.E. Epperson, J. Yu, L. Ellingsworth, and G.M. Glenn Immunostimulant patch containing heat labile enterotoxin from E. coli enhances immune responses to injected influenza vaccine through activation of skin dendritic cells J. Virol. 77 9 2003 5218 5225
13. M. Guebre-Xabier, S.A. Hammond, L.R. Ellingsworth, and G.M. Glenn Immunostimulant patch enhances immune responses to influenza virus vaccine in aged mice J. Virol. 78 14 2004 7610 7618
14. G.M. Glenn, R.T. Kenney, S.A. Hammond, and L.R. Ellingsworth Transcutaneous immunization and immunostimulant strategies Immunol. Allergy Clin. N. Am. 23 2003 787 813
15. G.M. Glenn, D.N. Taylor, X. Li, S. Frankel, A. Montemarano, and C.R. Alving Transcutaneous immunization: a human vaccine delivery strategy using a patch Nat. Med. 6 12 2000 1403 1406
16. S.A. Hammond, D. Walwender, C.R. Alving, and G.M. Glenn Transcutaneous immunization: T-cell responses and boosting of existing immunity Vaccine 19 2001 2701 2707
17. G.M. Glenn, R.T. Kenney, L.R. Ellingsworth, S.A. Frech, S.A. Hammond, and J.P. Zoeteweij Transcutaneous immunization and immunostimulant strategies: capitalizing on the immunocompetence of the skin Expert Rev. Vaccines 2 2 2003 253 267
18. K.L. Nichol Complications of influenza and benefits of vaccination Vaccine 17 Suppl. 1 1999 47 52
19. S. Gravenstein, and H.E. Davidson Current strategies for management of influenza in the elderly population Clin. Infect. Dis. 35 6 2002 729 737
20. D.C. Powers, and R.B. Belshe Effect of age on cytotoxic T lymphocyte memory as well as serum and local antibody responses elicited by inactivated influenza virus vaccine J. Infect. Dis. 167 3 1993 584 592
21. F. Güereña-Burgueño, E.R. Hall, and D.N. Taylor Safety and immunogenicity of a prototype enterotoxigenic Escherichia coli vaccine administered transcutaneously Infect. Immun. 70 4 2002 1874 1880
22. E.T. Ryan, T.I. Crean, M. John, J.R. Butterton, J.D. Clements, and S.B. Calderwood In vivo expression and immunoadjuvancy of a mutant of heat-labile enterotoxin of Escherichia coli in vaccine and vector strains of Vibrio cholerae Infect. Immun. 67 4 1999 1694 1701