Multiplicity of inferences in clinical trials: Adjustment methods, clinical interpretation issues;Du bon usage des tests dans les essais cliniques

Medecine/Sciences

Volumn 20, Issue 2, 2004, Pages 231-235

  Jouan Flahault, Chrystel ^a   Casset Semanaz, Florence ^b   Minini, Pascal ^b  

^a Les Entreprises du Médicament   (France)

^b GLAXOSMITHKLINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; CLINICAL RESEARCH; CLINICAL TRIAL; DATA ANALYSIS; REVIEW; STATISTICAL ANALYSIS; VALIDATION PROCESS;

EID: 1042302932     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/2004202231     Document Type: Review

References (10)

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3. Bauer P. Multiple testing in clinical trials. Stat Med 1991; 10: 871-90.
4. Senn S. Statistical issues in drug development. New york: Wiley, 1997.
5. Sankoh AJ, Huque MF, Dubey SD. Some comments on frequently used multiple endpoint adjustment methods in clinical trials. StatMed 1997; 16: 2529-42.
6. Holm S. A simple sequentially rejective multiple test procedure. Scand J Stat 1979; 6: 65-70.
7. ICH E9, Statistical principles for clinical trials. International conference on harmonisation of technical requirements for the registration of pharmaceuticals for human use. Adopted by CPMP, juillet 2000, issued as CPMP/ICH/364/96.
8. O'Brien P. Procedures for comparing samples with multiple endpoints. Biometrics 1984; 40: 1079-87.
9. Marcus R, Peritz E, Gabriel KR. On closed testing procedure with special reference to ordered analysis of variance. Biometrika 1976; 67: 655-60.
10. Point to consider on multiplicity issues in clinical trials. CPMP/EWP/908/99, adoption by CPMP, septembre 2002.