Metal-Induced Reversible Structural Interconversion of Human Mitochondrial NAD(P)+-Dependent Malic Enzyme

Proteins: Structure, Function and Genetics

Volumn 54, Issue 3, 2004, Pages 404-411

  Kuo, Chu Wei ^a   Hung, Hui Chih ^b   Tong, Liang ^c   Chang, Gu Gang ^d  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Enzyme conformation; Enzyme inhibition; Enzyme mechanism; Enzyme structure; Metal site; Slow binding

Indexed keywords

LUTETIUM; MALATE DEHYDROGENASE; MALATE DEHYDROGENASE (DECARBOXYLATING); MALATE DEHYDROGENASE (OXALOACETATE DECARBOXYLATING) (NAD+); MALATE DEHYDROGENASE-(OXALOACETATE-DECARBOXYLATING) (NAD+); MANGANESE; METAL; MITOCHONDRIAL ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME REACTIVATION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; ENZYMOLOGY; FLUORESCENCE; HUMAN; ISOMERISM; ISOMERIZATION; KINETICS; METABOLISM; METAL BINDING; MITOCHONDRION; PHOTOCHEMICAL QUENCHING; PRIORITY JOURNAL; PROTEIN CONFORMATION; SLOW BINDING;

BINDING SITES; CIRCULAR DICHROISM; ENZYME ACTIVATION; FLUORESCENCE; HUMANS; ISOMERISM; KINETICS; LUTETIUM; MALATE DEHYDROGENASE; MANGANESE; METALS; MITOCHONDRIA; MODELS, MOLECULAR; NAD; NADP; PROTEIN CONFORMATION;

COLUMBA; KOBUS;

EID: 1042291216     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10635     Document Type: Article

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