Immunogenicity of parathyroid allografts in the rat: Immunosuppressive dosages effective in passenger leukocyte-rich small bowel transplants are not effective in parathyroid gland transplants with few passenger leukocytes

Langenbeck's Archives of Surgery

Volumn 389, Issue 1, 2004, Pages 46-52

  Timm, S ^a   Otto, C ^b   Begrich, D ^b   Moskalenko, V ^b   Hamelmann, W ^a   Ulrichs, K ^b   Thiede, A ^a   Timmermann, W ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Department of Surgery ^*  (Germany)

Author keywords

Indirect allorecognition; Major histocompatibility complex (MHC); Parathyroids; Passenger leukocytes; Small intestine

Indexed keywords

CYCLOSPORIN A;

ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; HETEROTOPIC TRANSPLANTATION; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOHISTOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INTESTINE GRAFT; LEUKOCYTE RICH SMALL INTESTINE GRAFT; LONG TERM CARE; MALE; NONHUMAN; PARATHYROID TRANSPLANTATION; PARATHYROIDECTOMY; PRIORITY JOURNAL; RAT; SMALL INTESTINE;

ANIMALS; CALCIUM; CYCLOSPORINE; GRAFT REJECTION; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; LEUKOCYTES; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; PARATHYROID GLANDS; RATS; RATS, INBRED LEW; RATS, INBRED WF; TRANSPLANTATION, HOMOLOGOUS;

EID: 1042288465     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00423-003-0435-x     Document Type: Article

References (30)

1. Wingert DJ, Friesen SR, Iliopoulos JI, Pierce DE, Thomas JH, Hermreck AS (1986) Post-thyroidectomy hypocalcemia. Am J Surg 152:606-609
2. Arlt W, Fremerey C, Callies F, Reincke M, Schneider P, Timmermann W, Allolio B (2002) Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D. Eur J Endocrinol 146:215-222
3. Thomusch O, Machens A, Sekulla C, Ukkat J, Brauckhoff M, Dralle H (2003) The impact of surgical technique on postoperative hypoparathyroidism in bilateral thyroid surgery: a multivariate analysis of 5846 consecutive patients. Surgery 133:180-1853
4. Luts L, Sundler F (1998) Autotransplantation of parathyroid glands, a study on morphological changes. Transplantation 66:446-453
5. Hasse C, Zielke A, Klöck G, Schlosser A, Barth P, Zimmermann U, Sitter H, Lorenz W, Rothmund M (1998) Amitogenic alginates: key to first clinical application of microencapsulation technology. World J Surg 22:659-665
6. Hasse C, Klöck G, Schlosser A, Zimmermann U, Rothmund M (1997) Parathyroid allotransplantation without immunosuppression. Lancet 350:1296-1297
7. Saxe AW, Gibson G, Elfont E (1990) In vitro assessment of parathyroid immunogenicity: the effect of cryopreservation. Surgery 108:56-62
8. Wozniewicz B, Migaj M, Giera B, Prokurat A, Tollczko T, Sawichi A, Nawrot J, Gorski A, Zabritkowska T, Kossakowska AE (1996) Cell culture of human parathyroid cells. Transplant Proc 28:3542-3544
9. Timm S, Otto C, Gassel A, Hamelmann W, Timmermann W, Ulrichs K, Thiede A (2001) Influence of donor MHC antigen expression on graft survival after rat parathyroid allotransplantation. Langenbecks Arch Surg 386:430-433
10. Rahusen F, Munda R, Hariharan S, First MR, Demmy A (1997) Combined kidney-pancreas and parathyroid transplantation: a case report. Clin Transplant 11:341-343
11. Euvrard S, Kanitakis J, Claudy A (2003) Skin cancers after organ transplantation. N Engl J Med 348:1681-1691
12. Jenkins FJ, Rowe DT, Rinaldo CR Jr (2003) Herpes virus infections in organ transplant recipients. Clin Diagn Lab Immunol 10:1-7
13. Mahalati K, Kahan BD (2000) Pharmacological surrogates of allograft outcome. Ann Transplant 5:14-23
14. Lee KK, Langrehr JM, Stangl MJ, Banner B, Lee TK, Muller A, Schraut WH (1993) Successful treatment of ongoing intestinal allograft rejection permits recovery of graft structure and function. Am J Surg 165:131-136
15. Otto C, Gasser M, Waaga-Gasser AM, Rohde AC, Lenhard M, Jost S, Gassel HJ, Ulrichs K, Timmermann W (2002) Prolongation of small bowel allograft survival with a sequential therapy consisting of a synthetic MHC class II peptide and temporarily low-dose cyclosporine A. Hum Immunol 63:880-887
16. Timmermann W, Otto C, Gasser M, Meyer D, Parthum E, Schad J, Koch M, Gassel HJ, Ulrichs K, Thiede A (2000) Long-term small bowel allograft function induced by short-term FK 506 application is associated with split tolerance. Transpl Int 13 [Suppl 1]:532-536
17. Timmermann W, Gasser M, Meyer D, Kellersmann R, Gassel H-J, Otto C, Theide A (1999) Progress in experimental intestinal transplantation in small animal models. Acta Gastroenterol Belg 62:216-220
18. Schwarzenbach G (1955) The complexones and their analytical application. Analyst 80:713-729
19. Game DS, Lechler RJ (2002) Pathways of allorecognition: implications for transplantation tolerance. Transpl Immunol 10:101-108
20. Joosten SA, Van Knoten C, Paul SC (2003) Pathogenesis of chronic allograft rejection. Transpl Int 16:137-145
21. Fabre JW, Morris PJ (1973) The role of passenger leucocytes in the rejection of renal allografts in the rat. Transplantation 15:631-633
22. Sollinger HW, Mack E, Cook K, Belzer FO (1983) Allotransplantation of human parathyroid tissue without immunosuppression. Transplantation 36:599-603
23. Decker GA, Stark JH, Botha JR, Margolius LP, Decker G (1995) Allotransplantation of parathyroid cells. Lancet 345:124
24. Sekine Y, Bowen LK, Heidler KM, Van Rooijen N, Brown JW, Cummings OW, Wilkes DS (1997) Role of passenger leukocytes in allograft rejection: effect of depletion of donor alveolar macrophages on the local production of TNF-alpha, T helper 1/T helper 2 cytokines, IgG subclasses, and pathology in a rat model of lung transplantation. J Immunol 159:4084-4093
25. Rogers NJ, Lechler RI (2001) Allorecognition. Am J Transplant 1:97-102
26. Bjerneroth G, Juhlin C, Rastad J, Akerström G, Klareskog L (1993) MHC class I and II antigen expression on parathyroid tissue and prospects for their allogeneic transplantation. Transplantation 56:717-721
27. Bloom AD, Economou AD, Gebel HM (1986) Indefinite survival of rat parathyroid allografts without postoperative immunosuppression. Surgery 100:1032-1036
28. Niimi M, Takashina M, Takami H, Shirasugi N, Hamano K, Esato K, Matsumoto K, Ikeda Y, Shatari T, Kodaira S, Kameyama K (2000) Experimental parathyroid transplantation: human parathyroid grafts survived and functioned in mice treated with anti-CD4 monoclonal antibody. Biomed Pharmacother 54 [Suppl 1]:80-82
29. Waaga AM, Chandraker A, Spadafora-Ferreira M, Iyengar A, Khoury S, Carpenter C, Sayhed MH (1998) Mechanisms of indirect allorecognition. Transplantation 65:876-883
30. Shoskes DA, Wood KJ (1984) Indirect presentation of MHC antigens in transplantation. Immunol Today 15:32-38