Autoantibodies directed against the UDP-glucuronosyltransferases in human autoimmune hepatitis

Autoimmunity Reviews

Volumn 3, Issue 1, 2004, Pages 1-9

  Fabien, Nicole ^a   Desbos, Agnès ^a   Bienvenu, Jacques ^a   Magdalou, Jacques ^b  

^a CENTRE HOSPITALIER LYON SUD   (France)

^b Biopôle de l Université de Lorraine   (France)

Author keywords

Autoimmune hepatitis; LKM3 autoantibodies; UDP glucuronosyltransferases

Indexed keywords

AUTOANTIBODY; ENZYME ANTIBODY; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE ANTIBODY; LIVER KIDNEY MICROSOME ANTIBODY; MICROSOME ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; ANTIBODY TITER; AUTOIMMUNE HEPATITIS; DELTA AGENT HEPATITIS; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOFLUORESCENCE; KIDNEY MICROSOME; LIVER MICROSOME; NONHUMAN; PATHOGENESIS; REVIEW; WESTERN BLOTTING;

EID: 1042278954     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1568-9972(03)00051-X     Document Type: Review

References (39)

1. Alvarez F., Berg P.A., Bianchi F.B., et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 31:1999;929-938.
2. Crivelli O., Lavarini C., Chiaberge E., et al. Microsomal autoantibodies in chronic infection with the HBsAg associated delta (δ) agent. Clin Exp Immunol. 54:1983;232-238.
3. Philipp T., Durazzo M., Trautwein C., et al. Recognition of uridine diphosphate glucuronosyl transferases by LKM-3 antibodies in chronic hepatitis D. Lancet. 344:1994;578-581.
4. Strassburg C.P., Obermayer-Straub P., Alex B., et al. Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis. Gastroenterology. 111:1996;1576-1586.
5. Bachrich T., Thalhammer T., Jager W., et al. Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases. Hepatology. 33:2001;1053-1059.
6. Czaja A.J., Cassani F., Cataleta M., Valentini P., Bianchi F.B. Frequency and significance of antibodies to actin in Type 1 autoimmune hepatitis. Hepatology. 24:1996;1068-1073.
7. Donaldson P., Doherty D., Underhill J., Xilliams R. The molecular genetics of autoimmune liver disease. Hepatology. 20:1994;225-229.
8. Boberg K.M., Aadland E., Jahnsen J., Raknerud N., Stiris M., Bell H. Incidence and prevalence of primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis in a Norwegian population. Scand J Gastroenterol. 33:1998;99-103.
9. Obermayer-Straub P., Strassburg C.P., Manns M.P. Autoimmune hepatitis. J Hepatol. 32:2000;181-197.
10. Dalekos G.N., Zachou K., Liaskos C., Gatselis N. Autoantibodies and defined target autoantigens in autoimmune hepatitis: an overview. Eur J Intern Med. 13:2002;293-303.
11. Gregorio G.V., Portmann B., Reid F., et al. Autoimmune hepatitis in childhood: a 20-year experience. Hepatology. 25:1997;541-547.
12. Treichel U., Poralla T., Hess G., Manns M., Meyer zum Buschenfelde K.H. Autoantibodies to human asialoglycoprotein receptor in autoimmune-Type chronic hepatitis. Hepatology. 11:1990;606-612.
13. Homberg J.C., Abuaf N., Bernard O., et al. Chronic active hepatitis associated with anti-liver/kidney microsome antibody Type 1: a second Type of 'autoimmune' hepatitis. Hepatology. 7:1987;1333-1339.
14. Lunel F., Abuaf N., Frangeul L., et al. Liver/kidney microsome antibody Type 1 and hepatitis C virus infection. Hepatology. 16:1992;630-636.
15. Parez N., Herzog D., Jacqz-Aigrain E., Homberg J.C., Alvarez F. Study of the B cell response to cytochrome P450IID6 in sera from chronic hepatitis C patients. Clin Exp Immunol. 106:1996;336-343.
16. Vitozzi S., Lapierre P., Djilali-Saiah I., Alvarez F. Autoantibody detection in type 2 autoimmune hepatitis using a chimera recombinant protein. J Immunol Methods. 262:2002;103-110.
17. Lapierre P., Hajoui O., Homberg J.C., Alvarez F. Formiminotransferase cyclodeaminase is an organ-specific autoantigen recognized by sera of patients with autoimmune hepatitis. Gastroenterology. 116:1999;643-649.
18. Ballot E., Homberg J.C., Johanet C. Antibodies to soluble liver antigen: an additional marker in Type 1 autoimmune hepatitis. J Hepatol. 33:2000;208-215.
19. Ma Y., Okamoto M., Thomas M.G., et al. Antibodies to conformational epitopes of soluble liver antigen define a severe form of autoimmune liver disease. Hepatology. 35:2002;658-664.
20. Wies I., Brunner S., Henninger J., et al. Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis. Lancet. 355:2000;1510-1515.
21. Beaune P., Dansette P.M., Mansuy D., et al. Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hyroxylates the drug. Proc Natl Acad Sci USA. 84:1987;551-555.
22. Czaja A.J., Cassani F., Cataleta M., Valentini P., Bianchi F.B. Antinuclear antibodies and patterns of nuclear immunofluorescence in Type 1 autoimmune hepatitis. Dig Dis Sci. 42:1997;1688-1696.
23. Mulder A.H.L., Horst G., Haagsma E.B., Limburg P.C., Kleibeuker J.H., Kallenberg G.M. Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases. Hepatology. 17:1993;411-417.
24. Sobajima J., Ozaki S., Uesugi H., et al. High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 are significant target antigens of perinuclear anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis. Gut. 44:1999;867-873.
25. Mackenzie P.I., Owens I.S., Burchell B., et al. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics. 7:1997;255-269.
26. Meech R., Mackenzie P.I. Structure and function of uridine diphosphate glucuronosyl-transferases. Clin Exp Pharmacol Physiol. 24:1997;907-915.
27. Tukey R.H., Strassburg C.P. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol. 40:2000;581-616.
28. Siest G., Antoine B., Fournel S., Magdalou J., Thomassin J. The glucuronosyltransferases: what progress can pharmacologists expect from molecular biology and cellular enzymology? Biochem Pharmacol. 36:1987;983-987.
29. Georges H., Jarecki J., Netter P., Magdalou J., Lapicque F. Glycation of human serum albumin by acylglucuronides of nonsteroidal anti-inflammatory drugs of the series of phenylpropionates. Life Sci. 65:1999;25-30.
30. Fournel-Gigleux S., Jackson M.R., Wooster R., Burchell B. Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture. FEBS Lett. 243:1989;119-122.
31. Peters W.H., Jansen P.L. Immunocharacterization of UDP- glucuronyltransferase isoenzymes in human liver, intestine and kidney. Biochem Pharmacol. 37:1988;564-567.
32. Ghersi-Egea J.F., Perrin R., Leininger-Muller B., et al. Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain. Biochem Pharmacol. 45:1993;647-658.
33. Strassburg C.P., Manns M.P., Tukey R.T. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. J Biol Chem. 273:1998;8719-8726.
34. Bosma P.J., Chowdhury J.R., Bakker C., et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med. 333:1995;1171-1175.
35. Strassburg C.P., Manns M.P., Tukey R.H. Expression of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer. Cancer Res. 57:1997;2979-2985.
36. Obermayer-Straub P., Strassburg C., Clemente M.G., Philipp T., Tukey R.H., Manns M.P. Recognition of three different epitopes on UDP- glucuronosyltransferases by LKM-3 antibodies in patients with autoimmune hepatitis D. Gut. 37:1995;100A.
37. Robin M.A., Maratrat M., Le Roy M., et al. Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera. J Clin Invest. 98:1996;1471-1480.
38. Terrier N., Benoit E., Senay C., et al. Human and rat liver UDP-glucuronosyltransferases are targets of ketoprofen acylglucuronide. Mol Pharmacol. 56:1999;226-234.
39. Obermayer-Straub P., Strassburg C.P., Manns M.P. Target proteins in human autoimmunity: cytochromes P450 and UDP-glucuronosyltransferases. Can J Gastroenterol. 14:2000;429-439.