Changes in Orbital Hemodynamics Induced by Nipradilol in Healthy Volunteers

Journal of Ocular Pharmacology and Therapeutics

Volumn 20, Issue 1, 2004, Pages 25-33

  Nakanishi, Megumi ^a   Sugiyama, Tetsuya ^a   Nakajima, Masayuki ^a   Ikeda, Tsunehiko ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EYE DROPS; NIPRADILOL; NITRIC OXIDE DONOR;

ADULT; ARTERY DILATATION; ARTICLE; BLOOD FLOW VELOCITY; BLOOD PRESSURE MEASUREMENT; COLOR ULTRASOUND FLOWMETRY; CONTROLLED STUDY; DRUG EFFECT; EVALUATION; HEMODYNAMIC MONITORING; HUMAN; HUMAN EXPERIMENT; INTRAOCULAR PRESSURE; MALE; NORMAL HUMAN; OPHTHALMIC ARTERY; ORBIT; RETINA ARTERY; VASCULAR RESISTANCE;

EID: 1042277987     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/108076804772745437     Document Type: Article

References (34)

1. Rankin, S.J.A., Walman, B.E., Buckley, A.R., and Drance, S.M. Color Doppler imaging and spectral analysis of the optic nerve vasculature in glaucoma. Am. J. Ophthalmol. 119:685-693, 1995.
2. Nicolela, M.T., Drance, S.M., Rankin, S.J.A., Buckley, A.R., and Walman, B.E. Color Doppler imaging in patients with asymmetric glaucoma and unilateral visual field loss. Am. J. Ophthalmol. 121:502-510, 1996.
3. Butt, Z., O'Brien, C., McKillop, G., Aspinall, P., and Allan, P. Color Doppler imaging in untreated high- and normal-pressure open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 38:690-696, 1997.
4. Caprioli, J. and Spaeth, G.L. Comparison of visual field deffects in the low-tension glaucomas with those in the high-tension glaucomas. Am. J. Ophthalmol. 97:730-737, 1984.
5. Kaiser, H.J., Schoetzau, A., Stumpfig, D., and Flammer, J. Blood-flow velocities of the extraocular vessels in patients with high-tension and normal-tension primary open-angle glaucoma. Am. J. Ophthalmol. 123:320-327, 1997.
6. Grunwald, J.E. Effect of timolol maleate on the retinal circulation of human eyes with ocular hypertension. Invest. Ophthalmol. Vis. Sci. 31:521-526, 1990.
7. Grunwald, J.E. Effect of two weeks of timolol maleate treatment on the normal retinal circulation. Invest. Ophthalmol. Vis. Sci. 32:39-45, 1991.
8. Netland, P.A., Grosskreutz, C.L., Feke, G.T., and Hart, L.J. Color Doppler ultrasound analysis of ocular circulation after topical calcium channel blocker. Am. J. Ophthalmol. 119:694-700, 1995.
9. Harris, A., Spaeth, G.L., Sergott, R.C., Katz, L.J., Cantor, L.B., and Martin, B.J. Retrobulbar arterial hemodynamic effects of betaxolol and timolol in normal-tension glaucoma. Am. J. Ophthalmol. 120:168-175, 1995.
10. Netland, P.A., Schwartz, B., Feke, G.T., Takamoto, T., Konno, S., and Goger, D.G. Diversity of response of optic nerve head circulation to timolol maleate in gel-forming solution. J. Glaucoma 8:164-171, 1999.
11. Uji, Y. Effect of beta blockers on blood velocity in the orbital arteries in chronic open-angle glaucoma. In Vascular Risk Factors and Neuroprotection in Glaucoma - Update 1996, Drance, S.M., ed., Kugler Publications, Amsterdam, 1996, pp. 241-248.
12. Masuda, K., Takase, M., Kitazawa, Y., Shiose, Y., Azuma, I., Ogawa, N., and Ohdo, S. Phase III comparative clinical study on KT-210 in patients with primary open-angle glaucoma and ocular hypertension: multicenter cooperative between-group comparative double-blind clinical trial with 0.5% timolol maleate ophthalmic solution. J. Eye 13:1771-1783, 1996.
13. Kanno, M., Araie, M., Tomita, K., and Sawanobori, K. Effects of topical nipradilol, a β-blocking agent with α-blocking and nitroglycerin-like activities, on aqueous humor dynamics and fundus circulation. Invest. Ophthalmol. Vis. Sci. 39:736-743, 1998.
14. Kanno, M., Araie, M., Koibuchi, H., and Masuda, K. Effects of topical nipradilol, a β-blocking agent with ablocking and nitroglycerin-like activities, on intraocular pressure and aqueous dynamics in humans. Br. J. Ophthalmol. 84:293-299, 2000.
15. Sugiyama, T., Kida, T., Mizuno, K., Kojima, S., and Ikeda, T. Involvement of nitric oxide in the ocular hypotensive action of nipradilol. Curr. Eye Res. 23:346-351, 2001.
16. Okamura, T., Kitamura, Y., Uchiyama, M., Toda, M., Ayajiki, K., and Toda. N. Canine retinal arterial and arteriolar dilatation induced by nipradilol, a possible glaucoma therapeutic. Pharmacology 53:302-310, 1996.
17. Kojima, S., Sugiyama, T., Shimizu, K., Ishida, O., Nakajima, M., Azuma, I., and Goh, Y. Effect of a nitric oxide donor on intraocular pressure. J. Jpn. Ophthalmol. Soc. 100:181-186, 1996.
18. Sugiyama, T., Oku, H., Kojima, S., Shimizu, K., Ishida, O., and Azuma, I. Effect of nitric oxide donor on optic nerve head circulation. J. Jpn. Ophthalmol. Soc. 100:5-10, 1996.
19. Drance, S.M., Sweeney, V.P., Morgan, R.W., and Feldman, F. Studies of factors involved in the production of low tension glaucoma. Arch. Ophthalmol. 89:457-465, 1973.
20. Hamard, P., Hamard, H., Dufaux, J., and Quesnot, S. Optic nerve head blood flow using a laser Doppler velocimeter and haemorheology in primary open angle glaucoma and normal pressure glaucoma. Br. J. Ophthalmol. 78:449-453, 1994.
21. Phelps, C.D., and Corbett, J.J. Migraine and low-tension glaucoma. Invest. Ophthalmol. Vis. Sci. 26:1105-1108, 1985.
22. Shields, M.B. Textbook of glaucoma (3rd ed), Williams & Wilkins, Baltimore, 1992, pp. 175-177.
23. Araie, M., Sekine, M., Suzuki, Y., and Koseki, N. Factors contributing to the progression of visual field damage in eyes with normal-tension glaucoma. Ophthalmology 101:1440-1444, 1994.
24. Collaborative Normal-Tension Glaucoma Study Group: The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am. J. Ophthalmol. 126:498-505, 1998.
25. Baxter, G.M., Williamson, T.H., Mckillop, G., and Dutton, G.N. Color Doppler ultrasound of orbital and optic nerve blood flow: effects of posture and timolol 0.5%. Invest. Ophthalmol. Vis. Sci. 33:604-610, 1992.
26. Williamson, T.H., Frco, F., and Harris, A. Color Doppler ultrasound imaging of the eye and orbit. Surv. Ophthalmol. 40:255-267, 1996.
27. Quaranta, L., Harris, A., Donato, F., Cassamali, M., Semeraro, F., Nascimbeni, G., Gandolfo, E., and Quaranta, C.A. Color Doppler imaging of ophthalmic artery and blood flow velocity: a study of repeatability and agreement. Ophthalmology 104:653-658, 1997.
28. Alm, A. cular circulation. In Adler's Physiology of the Eye (9th ed), Hart, W.M. Jr., ed., CV Mosby Press, St. Louis, 1992, pp. 198-227.
29. Riva, C.E., and Loebl, M. Autoregulation of blood flow in the capillaries of the human macula. Invest. Ophthalmol. Vis. Sci. 16:568-571, 1997.
30. Riva, C.E., Grunwald, J.E., and Pettig, B.L. Autoregulation of human retinal blood flow - an investigation with laser Doppler velocimetry. Invest. Ophthalmol. Vis. Sci. 27:1706-1712, 1986.
31. Chiou, G.C.Y., Liu, S.X.L., Li, B.H.P., Chiang, C.H., and Varma, R.S. Ocular hypertensive effects of L-arginine and its derivatives and their actions on ocular blood flow. J. Ocular Pharmacol. 11:1-10, 1995.
32. Trible, J.R., Sergott, R.C., Speath, G.L., Wison, R.P., Katz, L.J., Moster, M.R., and Schmidt, C.M. Trabeculectomy is associated with retrobulbar hemodynamic changes - a color Doppler analysis. Ophthalmology 101:340-351, 1994.
33. Mizuno, K., Koide, T., Saito, N., Fujii, M., Nagahara, M., Tomidokoro, A., Tamaki, Y., and Araie, M. Topical nipradilol: effects on optic nerve head circulation in humans and periocular distribution in monkeys. Invest. Ophthalmol. Vis. Sci. 43:3243-3250, 2002.
34. Kida, T., Sugiyama, T., Harino, S., Kitanishi, K., and Ikeda, T. The effect of nipradilol, an α-β blocker, on retinal blood flow in healthy volunteers. Curr. Eye Res. 23:128-132, 2001.