Clinical Evaluation of Roxithromycin: A Double-Blind, Placebo-Controlled and Crossover Trial in Patients with Acne Vulgaris

Journal of Dermatology

Volumn 31, Issue 1, 2004, Pages 6-9

  Ferahbas, Ayten ^a   Utas, Serap ^a   Aykol, Deniz ^a   Borlu, Murat ^a   Uksal, Umit ^a  

^a ERCIYES UNIVERSITY   (Turkey)

Author keywords

Acne vulgaris; Roxithromycin

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN; CLARITHROMYCIN; CLINDAMYCIN; COTRIMOXAZOLE; CYTOKINE; ERYTHROMYCIN; MACROLIDE; ROXITHROMYCIN; TETRACYCLINE;

ACNE; ACNE VULGARIS; ADOLESCENT; ADULT; ANTIBIOTIC THERAPY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIARRHEA; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; FEMALE; GASTROINTESTINAL SYMPTOM; HEADACHE; HUMAN; INFLAMMATORY DISEASE; MALAISE; MALE; PATIENT COMPLIANCE; PROPIONIBACTERIUM ACNES; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; TREATMENT OUTCOME; VAGINA CANDIDIASIS;

EID: 1042275334     PISSN: 03852407     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2004.tb00496.x     Document Type: Article

References (16)

1. Odom RB, James MD, Berger TG: Acne, in: Andrews' Diseases of the Skin, 9th ed, WB Saunders Company, Philadelphia, 2000, pp 284-293.
2. Strauss JS, Thiboutot DM: Diseases of the sebaceous glands, in Fitzpatrick TB, Freedberg IM, Eisen AZ, Wolf K (eds): Dermatology in General Medicine, 5th ed, McGraw-Hill, New York, 1999, pp 769-784.
3. Nishijima S, Kurokawa I, Kawabata S: Sensitivity of Propionibacterium acnes isolated from acne patients: Comparative study of antimicrobial agents, J Int Med Res, 24: 473-477, 1996.
4. Akamatsu H, Nishijima S, Akamatsu M, Kurokawa I, Asada Y: Clinical evaluation of roxithromycin in patients with acne, J Int Med Res, 24: 109-114, 1996.
5. Eady EA, Cove JH, Holland KT, Cunliff WJ: Erythromycin resistant propionibacteria in antibiotic-treated acne patients association with therapeutic failure, Br J Dermatol, 121: 51-57, 1989.
6. Auffret N: Acne today, What's new?, Presse Med, 29: 1091-1097, 2000.
7. O'Brien SC, Lewis JB, Cunliffe WJ: The Leeds revised acne grading system, J Dermatol Treatment, 9: 215-220, 1998.
8. Akamatsu H, Tomita T, Horio T: Effects of roxithromycin on the production of lipase and neutrophil chemotactic factor by Propionibacterium acnes, Dermatology, 204: 277-280, 2002.
9. Johnson BA, Nunley JR: Use of systemic agents in the treatment of acne vulgaris, Am Fam Physician, 62: 1823-1836, 2000
10. Gruber F, Grubisic-Greblo H, Kastelan M, Brajac I, Lenkovic M, Zamolo G: Azithromycin compared with minocyline in the treatment of acne comedonica and papulo-pustulosa, J Chemother, 10: 469-473, 1998.
11. Fernandez-Obregon AC: Azithromycin for the treatment of acne, Int J Dermatol, 39: 45-50, 2000.
12. Nishijima S, Akamatsu H, Akamatsu M, Kurokawa I, Asada Y: The antibiotic susceptibility of Propionibacterium acnes and Staphylococcus epidermidis isolated from acne, J Dermatol, 21: 166-171, 1994.
13. Ianaro A, Ialenti A, Maffia P, et al: Anti-inflammatory activity of macrolide antibiotics, J Pharmacol Exp Ther, 292: 156-163, 2000.
14. Shimane T, Asano K, Mizutani T, Suzaki H: Inhibitory action of roxithromycin on tumour necrosis factor-alpha production from mast cells in vitro, In Vivo, 13: 503-506, 1999.
15. Wakita H, Tokura Y, Furukawa F, Takigawa M: The macrolide antibiotic, roxithromycin suppresses IFN-gamma-mediated immunological functions of cultured normal human keratinocytes, Biol Pharm Bull, 19: 224-227, 1996.
16. Scaglione F, Rossoni G: Comparative anti-inflammatory effects of roxithromycin, azithromycin and clarithromycin, J Antimicrob Chemother, 41: 47-50, 1998.