Effect of Astrocytic Energy Metabolism Depressant on 14C-Acetate Uptake in Intact Rat Brain

Journal of Cerebral Blood Flow and Metabolism

Volumn 24, Issue 2, 2004, Pages 188-190

  Hosoi, Rie ^a   Okada, Maki ^a   Hatazawa, Jun ^b   Gee, Antony ^c   Inoue, Osamu ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

14C acetate; Astrocytic metabolism; Fluorocitrate; Rat

Indexed keywords

ACETIC ACID; CARBON 14; CYTOTOXIN; FLUOROCITRIC ACID; IOFETAMINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; CELL METABOLISM; CONTROLLED STUDY; CORPUS STRIATUM; ENERGY METABOLISM; INFUSION; MALE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN;

EID: 1042266616     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000098606.42140.02     Document Type: Article

References (16)

1. 14C]acetate in caudate nucleus, thalamus and motor cortex (cat). Brain Res 12:444-455
2. Berl S (1973) Biochemical consequences of compartmentation of glutamate and associated metabolites. In: metabolic compartmentation in the Brain (Balazs R and Cremer JE, eds), London: Macmillan Press, pp 3-17
3. Broer S, Rahman B, Pellegri G, Pellerin L, Martin JL, Verleysdonk S, Hamprecht B, Magistretti PJ (1997) Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons. J Biol Chem 272:30096-30102
4. 13C NMR. J Biol Chem 265:12916-12926
5. Halestrap AP, Price NT (1999) The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 343:281-299
6. 13C NMR spectroscopic study. J Neurochem 64:2773-2782
7. Hassel B, Bachelard H, Jones P, Fonnum F, Sonnewald U (1997) Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate. J Cereb Blood Flow Metab 17:1230-1238
8. Juel C, Halestrap AP (1999) Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter. J Physiol 517:633-642
9. Martinez Hernandez A, Bell KP, Norenberg MD (1977) Glutamine synthetase: glial localization in brain. Science 195:1356-1358
10. Muir D, Berl S, Clarke DD (1986) Acetate and fluoroacetate as possible markers for glial metabolism in vivo. Brain Res 380:336-340
11. Paulsen RE, Contestabile A, Villani L, Fonnum F (1987) An in vivo model for studying function of brain tissue temporarily devoid of glial cell metabolism: the use of fluorocitrate. J Neurochem 48:1377-1385
12. Paxinos G, Watson C (1998) The Rat Brain in stereotaxic coordinates 4th edition, San Diego: Academic Press
13. Pierre K, Magistretti PJ, Pellerin L (2002) MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain. J Cereb Blood Flow Metab 22:586-595
14. Price NT, Jackson VN, Halestrap AP (1998) Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J 329:321-328
15. Shields AF, Graham MM, Kozawa SM, Kozell LB, Link JM, Swenson ER, Spence AM, Bassingthwaighte JB, Krohn KA (1992) Contribution of labeled carbon dioxide to PET imaging of carbon-11-labeled compounds. J Nucl Med 33:581-584
16. Waniewski RA, Martin DL (1998) Preferential utilization of acetate by astrocytes is attributable to transport. J Neurosci 18:5225-5233