Effects of Subinhibitory Concentrations of Macrolide Antibiotics on Pseudomonas aeruginosa

Chest

Volumn 125, Issue 2 SUPPL., 2004, Pages 62S-69S

  Wozniak, Daniel J ^a   Keyser, Rebecca ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine triphosphate binding cassette; Alginate; AsialoGM1; Biofilms; Cystic fibrosis transmembrane conductance regulator; Diffuse panbronchiolitis; Nucleotide binding domain; Pseudomonas aeruginosa; Twitching motility; Type IV pili

Indexed keywords

ADHESIN; ANTIINFECTIVE AGENT; CLARITHROMYCIN; MACROLIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATION; BIOFILM; BRONCHIOLITIS; CYSTIC FIBROSIS; DRUG EFFECT; DRUG EFFICACY; GROWTH INHIBITION; HOST PATHOGEN INTERACTION; HUMAN; LUNG INFECTION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PSEUDOMONAS AERUGINOSA; STRAIN IDENTIFICATION;

EID: 1042265016     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.125.2_suppl.62S     Document Type: Article

References (25)

1. Lyczak JB, Cannon C, Pier GB. Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microbes Infect 2000; 2:1051-1060
2. Pier GB. Pseudomonas aeruginosa: a key problem in cystic fibrosis. ASM News 1998; 6:339-347
3. Costerton JW, Stewart PS, Greenberg EP. Bacterial biofilms: a common cause of persistent infections. Science 1999; 284:1318-1322
4. Mah TC, O'Toole GA. Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol 2001; 9:34-39
5. Licking E. Getting a grip on bacterial slime. Business Week 1999; 13:98-100
6. Mattick JS, Whitchurch CB, Alm RA. The molecular genetics of type-4 fimbriae in Pseudomonas aeruginosa: a review. Gene 1996; 179:147-155
7. Mattick JS. Type IV pili and twitching motility. Annu Rev Microbiol 2002; 56:289-314
8. Shi W, Sun H. Type IV pilus-dependent motility and its possible role in bacterial pathogenesis. Infect Immun 2002; 70:1-4
9. Bradley DE. A function of Pseudomonas aeruginosa PAO polar pili: twitching motility. Can J Microbiol 1980; 26:146-154
10. Semmler A, Whitchurch CB, Mattick JS. A re-examination of twitching motility in Pseudomonas aeruginosa. Microbiology 1999; 145:2863-2873
11. Skerker JM, Berg HC. Direct observation of extension and retraction of type IV pili. Proc Natl Acad Sci U S A 2001; 98:6901-6904
12. Krivan HC, Roberts DD, Ginsburgh V. Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc beta 1-4 Gal found in some glycolipids. Proc Natl Acad Sci U S A 1988; 85:6157-6161
13. Imundo L, Barasch J, Prince A, et al. Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface. Proc Natl Acad Sci U S A 1995; 92:3019-3023
14. Prince A. Adhesins and receptors of Pseudomonas aeruginosa associated with infection of the respiratory tract. Microb Pathog 1992; 13:251-260
15. Sheth HB, Lee KK, Wong WY, et al. The pili of Pseudomonas aeruginosa strains PAK and PAO bind specifically to the carbohydrate sequence bGalNAc(1-4)bGal found in glycosphingolipids asialo-GM1 and asialo-GM2. Mol Microbiol 1994; 11:715-723
16. DiMango E, Zar HJ, Bryan R, et al. Diverse Pseudomonas aeruginosa gene products stimulate respiratory epithelial cells to produce interleukin-8. J Clin Invest 1995; 96:2204-2210
17. O'Toole GA, Kolter R. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Mol Microbiol 1998; 30:295-304
18. Comolli JC, Hauser AR, Waite L, et al. Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia. Infect Immun 1999; 67:3625-3630
19. Kang PJ, Hauser AR, Apodaca G, et al. Identification of Pseudomonas aeruginosa genes required for epithelial cell injury. Mol Microbiol 1997; 24:1249-1262
20. Kawamura-Sato K, Iinuma Y, Hasegawa T, et al. Effect of subinhibitory concentrations of macrolides on expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis. Antimicrob Agents Chemother 2000; 44:2869-2872
21. Kobayashi H. Biofilm disease: its clinical manifestation and therapeutic possibilities of macrolides. Am J Med 1995; 99:26S-30S
22. Bowman BJ, Bowman EJ. Mutations in subunit c of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site. J Biol Chem 2002; 277:3965-3972
23. O'Toole GA. Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple convergent signaling pathways: a genetic analysis. Mol Microbiol 1998; 28:449-461
24. Whitchurch CB, Erova TE, Emery JA, et al. Phosphorylation of the Pseudomonas aeruginosa response regulator AlgR is essential for type IV fimbria-mediated twitching motility. J Bacteriol 2002; 184:4544-4554
25. Wyckoff TJO, Wozniak DJ. Transcriptional analysis of genes involved in Pseudomonas aeruginosa biofilms. In: Doyle RJ, ed. Methods in enzymology. Pasadena, CA: Academic Press, 2001; 144-151