Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies

Molecular Therapy

Volumn 10, Issue 6, 2004, Pages 1140-1142

  Jiang, H ^a   Wang, Z ^a   Serra, D ^a   Frank, M M ^a   Amalfitano, A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Ad; Alternative complement pathway; Gene therapy; Toxicity

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENT COMPONENT C3; CYTOKINE; GENE PRODUCT; VIRUS ANTIBODY;

ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; CARDIOVASCULAR SYSTEM; CELLULAR IMMUNITY; CLEARANCE; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; CYTOKINE RELEASE; GENE TRANSFER; HOST CELL; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFLAMMATION; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN BINDING; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; VIRUS INFECTIVITY; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANTIBODIES; COMPLEMENT C3; COMPLEMENT PATHWAY, ALTERNATIVE; EDETIC ACID; EGTAZIC ACID; GENETIC VECTORS; HUMANS;

ADENOVIRIDAE;

EID: 10344260641     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.08.015     Document Type: Article

References (5)

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