Evaluation of the diffusion coefficient for controlled release of oxytetracycline from alginate/chitosan/poly(ethylene glycol) microbeads in simulated gastrointestinal environments

Biotechnology and Applied Biochemistry

Volumn 40, Issue 3, 2004, Pages 243-253

  Cruz, Maria C Pinto ^a   Ravagnani, Sergio P ^a   Brogna, Fabio M S ^a   Campana, Sérgio P ^b   Triviño, Galo Cardenas ^c   Lisboa, Antonio C Luz ^a   Mei, Lucia H Innocentini ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF CONCEPCIÓN   (Chile)

Author keywords

Alginate chitosan poly(ethylene glycol) microbeads; Controlled drug release; Oxytetracycline; Simulated gastrointestinal environment

Indexed keywords

CALCIUM COMPOUNDS; CHEMICAL RELAXATION; LEAST SQUARES APPROXIMATIONS; POLYETHYLENE GLYCOLS; SCANNING ELECTRON MICROSCOPY; SOLUBILITY; VISCOSITY;

DIFFUSIVITY; FREE WATER; GASTROINTESTINAL SYSTEMS; MICROBEADS;

DIFFUSION;

ALGINIC ACID; CHITOSAN; MACROGOL; OXYTETRACYCLINE;

ARTICLE; CONTROLLED RELEASE FORMULATION; DIFFUSION COEFFICIENT; DRUG SCREENING; DRUG SOLUBILITY; GASTROINTESTINAL TRACT; MATHEMATICAL ANALYSIS; PH;

ALGINATES; ANIMALS; ANTI-BACTERIAL AGENTS; CHITOSAN; COATED MATERIALS, BIOCOMPATIBLE; COMPUTER SIMULATION; DELAYED-ACTION PREPARATIONS; DIFFUSION; DRUG CARRIERS; GASTROINTESTINAL CONTENTS; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; MATERIALS TESTING; MICROSPHERES; MODELS, CHEMICAL; OXYTETRACYCLINE; POLYETHYLENE GLYCOLS;

EID: 10344260637     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20030216     Document Type: Article

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