Neurokinin receptors: Relevance to the emerging immune system

Archivum Immunologiae et Therapiae Experimentalis

Volumn 52, Issue 5, 2004, Pages 338-347

  Kang, Helen S ^a,b   Trzaska, Katarzyna A ^a,b   Corcoran, Kelly ^a,b   Chang, Victor T ^a,c   Rameshwar, Pranela ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cytokines; Hematopoiesis; Neurokinin; Neuropeptides; Substance P

Indexed keywords

AMINO ACID; CYTOKINE; NEUROKININ A; NEUROTRANSMITTER; SUBSTANCE P; TACHYKININ; TACHYKININ RECEPTOR;

BONE MARROW; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; PROTEIN INTERACTION; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; REVIEW;

ANIMALS; CYTOKINES; HEMATOPOIESIS; HUMANS; NEUROSECRETORY SYSTEMS; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; RECEPTORS, NEUROKININ-3; TACHYKININS;

EID: 10344253837     PISSN: 0004069X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (78)

1. Afan A. M., Broome C. S., Nicholls S. E., Whetton A. D. and Miyan J. A. (1997): Bone marrow innervation regulates cellular retention in the murine haemopoietic system. Br. J. Haematol., 98, 569-577.
2. Anjaria D. J., Rameshwar P., Deitch E. A., Xu Da-Zhong, Adams C. A., Forsythe R. M., Sambol J. T., Hauser C. J. and Livingston D. H. (2001): Hematopoietic failure following hemorrhagic shock is mediated partially through mesenteric lymph. Crit. Care Med., 29, 1780-1785.
3. Anjaria D. J., Rameshwar P., Zhong X.-D., Adams C. A., Forsythe R. M., Sambol J. T., Hauser C. J., Deitch E. A. and Livingston D. H. (2000): Hematopoietic failure following hemorrhagic shock is partially mediated by the gut. Surg. Forum, 51, 169-171.
4. Arai F., Ohneda O., Miyamoto T., Zhang X. Q. and Suda T. (2002): Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J. Exp. Med., 195, 1549-1563.
5. Bandari P. S., Qian J., Oh H. S., Potian J. A., Yehia G., Harrison J. S, and Rameshwar P. (2003): Crosstalk between neurokinin receptors is relevant to hematopoietic regulation: cloning and characterization of neurokinin2 promoter. J. Neuroimmunol., 138, 65-75.
6. Bandari, P. S., Qian J., Yehia G., Joshi D. D., Maloof P. B., Potian J., Oh H. S., Gascon P., Harrison J. S. and Rameshwar P. (2003): Hematopoietic growth factor inducible neurokinin-1 type: a transmembrane protein that is similar to neurokinin 1 interacts with substance P. Regul. Pept., 111, 169-178.
7. Bandari P. S., Qian J., Yehia G., Seegopaul H. P., Harrison J. S., Gascon P., Fernandes H. and Rameshwar P. (2001): Differences in the expression of neurokinin receptor in neural and bone marrow mesenchymal cells: implications for neuronal expansion from bone marrow cells. Neuropeptides, 36, 13-21.
8. Beaujouan J. C., Torrens Y., Saffroy M., Kemel M. L. and Glowinski J. (2004): A 25 year adventure in the field of tachykinins. Peptides, 25, 339-357.
9. Bellucci F., Carini F., Catalani C., Cucchi P., Lecci A., Meini S., Patacchini R., Quartara L., Ricci R., Tramontana M., Giuliani S. and Maggi C. A. (2002): Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. Br. J. Pharmacol., 135, 226-274.
10. Bhatt R., Rameshwar P., Goldstein K. and Siegel A. (2003): Effects of kindled seizures upon hematopoiesis in rats. Epilepsy Res., 54, 209-219.
11. Blanco P., Riminucci M., Gronthos S., and Robey P. G. (2001): Bone marrow stromal stem cells: Nature, biology, and potential applications. Stem Cells, 19, 180-192.
12. Cao T., Pintér E., Al-Rashed S., Gerard N., Hoult J. R. and Brain S. D. (2000): Neurokinin-1 receptor agonists are involved in mediating neutrophil accumulation in the inflamed, but not normal, cutaneous microvasculature: an in vivo study using neurokinin-1 receptor knockout mice. J. Immunol., 164, 5424-5429.
13. Coa Y. A., Wagers A. J., Beilhack A., Dusich J., Bachmann M. H., Negrin R. S., Weissman I. L. and Contag C. H. (2004): Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc. Natl. Acad. Sci. USA, 101, 221-226.
14. Caplan A. I. and Bruder S. P. (2001): Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol. Med., 7, 259-264.
15. Carter M. S. and Krause J. E. (1990): Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide γ. J. Neurosci., 10, 2203-2214.
16. Deans R. J. and Moseley A. B. (2000): Mesenchymal stem cells: biology and potential clinical uses. Exp. Hematol., 28, 875-884.
17. Donnelly D., Maudsley S., Gent J. P., Moser R. N., Hurrell C. R. and Findlay J. B. C. (1999): Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications. Biochem. J., 339, 55-61.
18. Fehder W. P. and Douglas S. D. (2001): Interactions between the nervous and immune systems. Semin. Clin. Neuropsychiatry, 6, 229-240.
19. Fras C., Kravetz P., Mody D. R. and Heggeness M. H. (2003): Substance P-containing nerves within the human vertebral body: an immunohistochemical study of the basiverterbral nerve. Spine J., 3, 63-67.
20. Graham G. J., Stevens J. M., Page N. M., Grant A. D., Brain S. D., Lowry P. J. and Gibbins J. M. (2004): Tachykinins regulate the function of platelets. Blood, 104, 1058-1065.
21. Goto T. and Tanaka T. (2002): Tachykinins and tachykinin receptors in the bone. Microsc. Res. Tech., 58, 91-97.
22. Goto T., Yamaza T., Mizuho A. and Tanaka K. T. (1998): Light-and electron-microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone. Cell Tissue Res., 293, 87-93.
23. Greco S. J., Corcoran K. E., Cho K. J. and Rameshwar P. (2004): Tachykinins in the emerging immune system: relevance to bone marrow homeostasis and maintenance of hematopoietic stem cells. Front Biosci., 9, 1782-1793.
24. Hiramoto M., Aizawa S., Iwase O., Nakano M., Toyama K., Hoque M., Nabeshima R., Kaidow A., Imai T., Hoshi H. and Handa H. (1998): Stimulatory effects of substance P on CD34 positive cell proliferation and differentiation in vitro are mediated by the modulation of stromal cell function. Int. J. Mol. Med., 1, 347-354.
25. Iversen P. O., Hjeltnes N., Holm B., Flatebo T., Strom-Gundersen I., Ronning W., Stanghelle J. and Benestad H. B. (2000): Depressed immunity and impaired proliferation of hematopoietic progenitor cells in patients with complete spinal cord injury. Blood, 96, 2081-2083.
26. Joshi D. D., Dang A., Yadav P., Qian J., Bandari P. S., Chen K., Donnelly R., Castro T., Gascon P., Haider A. and Rameshwar P. (2001): Negative feedback on the effects of stem cell factor on hematopoiesis is party mediated through neutral endopeptidase activity on substance P: a combined functional and proteomic study. Blood, 98, 2697-2706.
27. Kaushansky K. and Karplus A. P. (1993): Hematopoietic growth factors: understanding functional diversity in structural terms. Blood, 82, 3229.
28. Kondo M., Wagers A. J., Manz M. G., Prohaska S. S, Scherer D. C., Beilhack G. F., Shizuru J. A. and Weissman I. L. (2003): Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu. Rev. Immunol., 21, 759-806.
29. Kreisberg R., Detrick M. S. and Moore R. N. (1993): Opposing effects of tumor necrosis factor alpha and leukemia inhibitory factor in lipopolysaccharide-stimulated myelopoiesis. Infect. Immun., 61, 418-422.
30. Li Y., Douglas S. D. and Ho W. D. (2000): Human stem cells express substance P gene and its receptor. J. Hematother. Stem Cell Res., 9, 445.
31. Maestroni G. J. M. (1995): Adrenergic regulation of haematopoiesis. Pharmacol. Res., 32, 249-253.
32. Maloof P. B., Joshi D. D., Qian J., Gascon P., Singh D. and Rameshwar P. (2001): Induction of preprotachykinin-I and neurokinin-1 by adrenocorticotropin and prolactin. Implication for neuroendocrine-immune-hematopoietic axis. J. Neuroimmunol., 112, 188-196.
33. Manz M. G., Traver D., Miyamoto T., Weissman I. L. and Akashi K. (2001): Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood, 97, 3333-3341.
34. Moore K. A., Ema H. and Lemischka I. R. (1997): In vitro maintenance of highly purified, transplantable hematopoietic stem cells. Blood, 89, 4337-4347.
35. Morrison S. J., Shah N. M. and Anderson D. J. (1997): Regulatory mechanisms in stem cell biology. Cell, 88, 287-298.
36. Morteau O., Lu B., Gerard C. and Gerard N. P. (2001): Hemokinin I is a full agonist at the substance P receptor. Nat. Immunol., 2, 1088.
37. Muller-Sieburg C. E. and Deryugina E. (1995): The stromal cells' guide to the stem cell universe. Stem Cells, 13, 477-486.
38. Novotny G. E. K. (1992): Direct innervation of lymphatic organs in the rat. Ann. NY Acad. Sci., 650, 6-8.
39. Nowicki M. and Miskowiak B. (2003): Substance P - a potent risk factor in childhood lymphoblastic leukaemia. Leukemia, 6, 1096-1099.
40. Nowicki M., Miskowiak B. and Ostalska-Nowicka D. (2003): Detection of substance P and its mRNA in human blast cells in childhood lymphoblastic leukaemia using immunocytochemistry and in situ hybridisation. Folia Histochem. Cytobiol., 41, 33-36.
41. Owen T. A., Smock S. L., Prakash S., Pinder L., Brees D., Krull D., Castleberry T. A., Clancy Y. C., Marks S. C. Jr., Safadi F. F. and Popoff S. N. (2003): Identification and characterization of the genes encoding human and mouse osteoactivin. Crit. Rev. Eukaryot. Gene Expr., 13, 205-220.
42. Oyamada H., Takatsuji K., Senba E., Mantyh P. W. and Tohyama M. (1999): Postnatal development of NK1, NK2, and NK3 neurokinin receptors expression in the rat retina. Brain Res. Dev. Brain Res., 117, 59-70.
43. Page N. M., Bell N. J., Gardiner S. M., Manyonda I. T., Brayley K. J., Strange P. G. and Lowry P. J. (2003): Characterization of the endokinins: human tachykinins with cardiovascular activity. Proc. Natl. Acad. Sci. USA, 100, 6245-6250.
44. Pascual D. W., Bost K. L., Xu-Amano J., Kiyono H. and McGhee J. R. (1992): The cytokine-like action of substance P upon B cell differentiation. Reg. Immunol., 4, 100-104.
45. Patacchini R., Lecci A., Holzer P. and Maggi C. (2004): Newly discovered tachykinins raise new questions about their peripheral roles and the tachykinin nomenclature. Trends Pharmacol. Sci., 25, 1-3.
46. Patacchini R. and Maggi C. A. (2001): Peripheral tachykinin receptors as targets for new drugs. Eur. J. Pharmacol., 429, 13-21.
47. Pennefather J. N., Lecci A., Candenas M. L., Patak E., Pinto F. M. and Maggi C. A. (2004): Tachykinins and tachykinin receptors: a growing family. Life Sci., 74, 1445-1463.
48. Punzel M. and Ho A. D. (2001): Divisional history and pluripotency of human hematopoietic stem cells. Ann. NY Acad. Sci., 938, 72-81.
49. Qian J., Ramroop K., McLeod A., Bandari P., Livingston D. H., Harrison J. S. and Rameshwar P. (2001): Induction of hypoxia-inducible factor-1α and caspase-3 in hypoxic bone marrow stroma is negatively regulated by the delayed production of substance P. J. Immunol., 167, 4600-4608.
50. Quartara L. and Maggi C. A. (1998): The tachykinin NK1 receptor: part II. Distribution and pathophysiological roles. Neuropeptides, 32, 1-49.
51. Quinlan D. Jr., Rameshwar P., Qian J., Maloof P. B., Mohr A. M., Hauser C. J. and Livingston D. H. (1998): Effect of hypoxia on the hematopoietic and immune modulator preprotachykinin-1. Arch. Surg., 133, 1328-1334.
52. Rameshwar P. (1997): Substance P: a regulatory neuropeptide for hematopoiesis and immune functions. Clin. Immunol. Immunopathol., 85, 129-133.
53. Rameshwar P., Ganea D. and Gascón P. (1993): In vitro stimulatory effect of substance P on hematopoiesis. Blood, 81, 391-398.
54. Rameshwar P. and Gascon P. (1995): Substance P (SP) mediates production of stem cell factor and interleukin-1 in bone marrow stroma: potential autoregulatory role for these cytokines in SP receptor expression and induction Blood, 86, 482-490.
55. Rameshwar P. and Gascon P. (1996): Induction of negative hematopoietic regulators by neurokinin-A in bone marrow stroma. Blood, 88, 98-106.
56. Rameshwar P. and Gascon P. (1996): Neural regulation of hematopoiesis by the tachykinins. Mol. Biol. Hemat., 5, 463.
57. Rameshwar P. and Gascon P. (1997): Hematopoietic modulation by the tachykinins. Acta Haematol., 98, 59-64.
58. Rameshwar P., Gascon P. and Ganea D. (1993): Stimulation of interleukin 2 production in murine lymphocytes by substance P and related tachykinins. J. Immunol., 151, 2484-2496.
59. Rameshwar P., Joshi D. D., Yadav P., Gascón P., Qian J., Chang V. T., Anjaria A., Harrison J. S. and Xiaosong S. (2001): Mimicry between neurokinin-1 and fibronectin may explain the transport and stability of increased substance P-immunoreactivity in patients with bone marrow fibrosis. Blood, 97, 3025-3031.
60. Rameshwar P., Oh H. S., Yook C., Gascon P. and Chang V. T. (2003): Substance P-fibronectin-cytokine interactions in myeloproliferative disorder with bone marrow fibrosis. Acta Haematol., 109, 1-10.
61. Rameshwar P., Poddar A. and Gascón, P. (1997): Hematopoietic regulation mediated by interactions among the neurokinins and cytokines. Leuk. Lymphoma, 28, 1-10.
62. Santoni G., Amantini C., Lucciarini R., Pompei P., Perfumi M., Nabissi M., Morrone S. and Picoli M. (2003): Expression of substance P and its neurokinin-1 receptor on thymocytes: functional relevance in the regulation of thymocyte apoptosis and proliferation. Neuroimmunomodulation, 10, 232-246.
63. Scholzen T. E., Steinhoff M., Sindrilaru A., Schwarz A., Bunnett N. W., Luger T. A., Armstrong C. A. and Ansel J. C. (2004): Cutaneous allergic contact dermatitis responses are diminished in mice deficient in neurokinin 1 receptors and augmented by neurokinin 2 receptor blockage. FASEB J., 18, 1007-1009.
64. Selim A. A., Abdelmagid S. M., Kanaan R. A., Smock S. L., Owen T. A., Popoff S. N. and Safadi F. F. (2003): Anti-osteoactivin antibody inhibits osteoblast differentiation and function in vitro. Crit. Rev. Eukaryot. Gene Expr., 13, 265-275.
65. Simeonidis S., Castagliuolo I., Pan A., Liu J., Wang C. C., Mykoniatis A., Pasha A., Valenick L., Sougioultzis S., Zhao D. and Pothoulakis C. (2003): Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-κB site on its promoter. Proc. Natl. Acad. Sci. USA, 100, 2957-2962.
66. Suzuki R., Furuno T., McKay D. M., Wolvers D., Teshima R., Nakanishi M. and Bienenstock J. (1999): Direct neurite-mast cell communication in vitro occurs via the neuropeptide substance P. J. Immunol., 163, 2410-2415.
67. Tabarowski Z., Gibson-Berry K. and Felten S. Y. (1996): Noradrenergic and peptidergic innervation of the mouse femur bone marrow. Acta Histochem., 98, 453-457.
68. Van Hagen P. M., Krenning E. P., Kwekkeboom D. J., Reubi J. C., Anker-Lugtenburg P. J., Lowenbert B. and Lamberts S. W. (1994): Somatostatin and the immune and haematopoetic system: a review. Eur. J. Clin. Invest., 24, 91-99.
69. Weihe E., Nohr D., Michel S., Muller S., Zentel H. J., Fink T. and Krekel J. (1991): Molecular anatomy of the neuro-immune comnection. Int. J. Neurosci., 59, 1-23.
70. Weinstock J. V. (2004): The role of substance P, hemokinin and their receptor in governing mucosal inflammation and granulomatous responses. Front Biosci., 9, 1936-1943.
71. Weterman M. A., Ajubi N., van Dinter I. M., Degen W. G., van Muijen G. N., Ruitter D. J. and Bloemers H. P. (1995): nmb, a novel gene, is expressed in low-metastatic human melanoma cell lines and xenografts. Int. J. Cancer, 60, 73-81.
72. Wu C. J., Livingston D. H., Hauser C. J., Deitch E. A. and Rameshwar P. (2001): Trauma inhibits BFU-E and CFU-GM colony growth through the production of TGF-β1 by bone marrow stroma. Ann. Surg., 234, 224-232.
73. Yamazaki K. and Allen T. D. (1990): Ultrastructural morphometric study of efferent nerve terminals on murine bone marrow stromal cells, and the recognition of a novel anatomical unit: the "neuro-reticular complex". Am. J. Anat., 187, 261-276.
74. Yao R., Rameshwar P., Donnelly R. J. and Siegel A. (1999): Neurokinin-1 expression and colocalization with glutamate and GABA in the hypothalamus of the cat. Mol. Brain Res., 71, 149-158.
75. Zhang Y., Lu L., Furlonger C., Wu G. E. and Paige C. J. (2000): Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nat. Immunol., 1, 392-397.
76. Zhang Y. and Paige C. J. (2003): T-cell developmental blockage by tachykinins antagonists and the role of hemokinin 1 in T lymphopoiesis. Blood, 102, 2165-2172.
77. Zhou D., Kusnecov A. W., Shurin M, R., DePaoli M. and Rabin B. S. (1993): Exposure to physical and psychological stressors elevates plasma interleukin 6: relationship to the activation of hypothalamic-pituitary-adrenal axis. Endocrinology, 133, 2523-2530.
78. Zon L. I. (1995): Developmental biology of hematopoiesis. Blood, 86, 2876-2891.