Antioxidant activity of N-substituted indole 2- and 3-carboxamides

Ankara Universitesi Eczacilik Fakultesi Dergisi

Volumn 33, Issue 2, 2004, Pages 109-116

  Ölgen, Süreyya ^a   Çoban, Tülay ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Antioxidant activity; Lipid peroxidation; N substituted and N H indole amide derivatives; Superoxide dismutases

Indexed keywords

ALPHA TOCOPHEROL; AMIDE; INDOLE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE;

ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; LIPID PEROXIDATION; LIVER MICROSOME; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

EID: 10344252823     PISSN: 10153918     EISSN: 25646524     Source Type: Journal    
DOI: 10.1501/eczfak_0000000404     Document Type: Article

References (14)

1. Shen, T. Y., Winter, C. A. "Chemical And Biological Studies On Indomethacin, Sulindac And Their Analogs" Advances İn Drug Research, 12, 89 (1977).
2. Unangst, P. C., Conner, D. T., Stabler, R. S., Weikert, R. J., Carethers, M. E., Kennedy, J. A., Thueson, D. Q., Chesnut, J. C., Adolphson, R. L. Conroy, M. C. "Novel Indolecarboxamidotetrazoles As Potential Antiallergy Agents" J. Med. Chem. 32, 1360 (1989).
3. Williams, T. M., Ciccarone, T. M., Mactough, S. C., Rooney, C. S., Balani, S. K., Condra, J. H., Einini, E. A., Goldman, M. E., Greenlee, W. J., Kauffman, L. R., O'brien, J. A., Sardana, V. V., Schleif, W. A., Theoharides, A. D., Anderson, P. S. "5-Chloro-3-(Phenylsulfonyl)İndole-2-Carboxamide: A Novel, Non-Nucleoside İnhibitor Of HIV-1 Reverse Transcriptase" J. Med. Chem. 36, 1291 (1993).
4. Kelly, T. A., Mcneil, D. W., Rose, J. M., David, E., Shih, C. K., Grob, P. M. "Novel Non-Nucleoside İnhibitors Of Human İmmunodeficiency Virus Type 1 Reverse Transcriptase. 6. 2-İndol-3-Y1- And 2-Azaindol-3-Y1-Dipyridodiazepinones" J. Med. Chem. 40, 2430 (1997).
5. Mendel, D. B., Laird, A. D., Smolich, B. D., Blake, R. A., Liang, C., Hannah, A. L., Shaheen, R. M., Ellis, L. M., Weitman, S., Shawver, L. K., Cherrington, J. M. "Development Of Su5416, A Selective Small Molecule İnhibitor Of Vgef Receptor Thyrosine Kinase Activity, As An Anti-Angiogenesis Agent" Anti-Cancer Drug Design, 15, 29 (2000).
6. Cirrincione, G., Almerico, A. M., Barraja, P., Diana, P., Lauria, A., Passannanti, A., Musiu, C., Pani, A., Murtas, P., Minnei, C., Marongui, M. E., Lacolla, P. "Derivatives Of The New Ring System İndolo[1,2-C]Benzo[1, 2,3]Triazine With Potent Antitumor And Antimicrobial Activity" J. Med. Chem. 42, 2561 (1999).
7. Kim, D. H., Guinosso, C. J., Buzby, G. C., Herbst, D. R., Mccaully, R. J. "Mercaptopropanoyl İndoline-2-Carboxylic Acids And Related Compounds As Potent Angiotensin Converting Enzyme İnhibitors And Antihypertansive Agents" J. Med. Chem. 26, 394 (1983).
8. Antosiewich, J., Damiani, E., Jassem, W., Wozniak, M., Orena, M., Greci, L. "Influence Of Structure On The Antioxidant Activity Of İndolinic Nitroxide Radicals" Free Radical Biology And Medicine, 22, 249 (1997).
9. Sreejayan, N., Mao, M. N. A. "Free Radical Scavenging Activity Of Curcuminoids" Arzneim.-Forsch./Drug Res. 46, 169 (1996).
10. Ölgen, S., Çoban, T. "Synthesis And Antioxidant Properties Of Novel N- Substituted İndole 2-Carboxamide And 3-Acetamide Derivatives" Arch. Pharm. 335, 331 (2002).
11. Ölgen, S., Güner, E., Fabregat, A. M., Crespo, M. I., Nebioǧlu, D. "Syntheses And Biological Evaluation Of İndole-2 And 3-Carboxamides: New Selective Cyclooxygenase-2 İnhibitors" Die Pharmazie, 57, 238 (2002).
12. Mccord, J. M., Fridovich, J. M. "Preparation And Assay Of Superoxide Dismutases" Methods Enzymol. 53, 382 (1978).
13. 4 İntoxication, And Vitamin E Deficiency" Biochem. Med. 23, 303 (1980).
14. Arutla, S., Arra, G. S., Prabhakar, C. M., Krishna, D. R. "Pro- And Anti-Oxidant Effects Of Some Antileprotic Drugs İn Vitro And Their İnfluence On Super Oxide Dismutase Activity" Arzneim.-Forsch./Drug Res. 48, 1024 (1998).