Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1- pyrophosphate availability in rat hepatocyte cultures

Nucleosides, Nucleotides and Nucleic Acids

Volumn 23, Issue 8-9, 2004, Pages 1235-1239

  Boer, Pnina ^a   Sperling, Oded ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

5 Phosphoribosyl 1 pyrophosphate; Caffeine; CP 91149; Dibutyryl cyclic AMP; Forskolin; Glucagon; Glycogenolysis

Indexed keywords

BUCLADESINE; CAFFEINE; FORSKOLIN; GLUCAGON; GLYCOGEN PHOSPHORYLASE; PHOSPHORIBOSYL PYROPHOSPHATE;

ANIMAL CELL; BIOAVAILABILITY; CONFERENCE PAPER; ENZYME ACTIVITY; ENZYME INHIBITION; GLYCOGEN LIVER LEVEL; GLYCOGEN STORAGE DISEASE TYPE 1; GLYCOGENOLYSIS; LIVER CELL CULTURE; MALE; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PROTEIN CONTENT; PROTEIN DEGRADATION; RAT; RECEPTOR AFFINITY; RECEPTOR DENSITY;

AMIDES; ANIMALS; ARGININE VASOPRESSIN; BUCLADESINE; CAFFEINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FORSKOLIN; GLUCAGON; GLYCOGEN PHOSPHORYLASE; HEPATOCYTES; INDOLES; LIVER; MALE; PHENYLEPHRINE; PHOSPHORIBOSYL PYROPHOSPHATE; RATS; RATS, WISTAR; TIME FACTORS;

ANIMALIA;

EID: 10344247158     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-200027496     Document Type: Conference Paper

References (8)

1. Becker, M.A. Hyperuricemia and gout. In The Metabolic and Molecular Bases of Disease, 8th Ed.; Scriver, C.R., Beaudet, A.L., Sly, W.S., Valle, D., Childs, B., Kinzler, K.W., Vogelstein, B., Eds.; McGraw-Hill: New York, NY, 2001; 2513-2535.
2. Chen, Y.-T. Glycogen storage diseases. In The Metabolic and Molecular Bases of Disease, 8th Ed.; Scriver, C.R., Beaudet, A.L., Sly, W.S., Valle, D., Childs, B., Kinzler, K.W., Vogelstein, B., Eds.; McGraw-Hill: New York, NY, 2001; 1521-1551.
3. Boer, P.; Mamet, R.; Sperling, O. Acceleration of purine synthesis in mouse liver by glycogenolytic hormones. Biochem. Med. Metab. Biol. 1991, 46, 185-195.
4. Boer, P.; Sperling, O. The role of cellular ribose-5-phosphate content in the regulation of 5-phosphoribosyl-1-pyrophosphate and de novo purine synthesis in human hepatoma (HepG2) cell line. Metabolism 1995, 44, 1469-1474.
5. Seglen, P.O. Preparation of isolated rat liver cells. Methods Cell Biol. 1976, 13, 29-83.
6. Christophe, J. Glucagon receptors: from genetic structure and expression to effector coupling and biological responses. Biochim. Biophys. Acta 1995, 1241, 45-57.
7. Itoh, H.; Okajima, F.; Ui, M. Conversion of adrenergic mechanism from an alpha- to a beta-type during primary culture of rat hepatocytes. Accompanying decreases in the function of the inhibitory guanine nucleotide regulatory component of adenylate cyclase identified as the substrate of islet-activating protein. J. Biol. Chem. 1984, 259, 15464-15473.
8. Martin, W.H.; Hoover, D.J.; Armento, S.J.; Stock, I.A.; et al. Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo. Proc. Natl. Acad. Sci. U. S. A. 1998, 95, 1776-1781.