α-lipoic acid, an anti-obesity agent?

Expert Opinion on Investigational Drugs

Volumn 13, Issue 12, 2004, Pages 1641-1643

  Doggrell, Sheila A ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Doggrell Biomedical Communications   (New Zealand)

Author keywords

lipoic acid; AMP activated protein kinae; Body weight; Obesity; Otsuka Long Evans Tokushima Fatty rats

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A CARBOXYLASE; ANTIOBESITY AGENT; CORTICOTROPIN RELEASING FACTOR; FATTY ACID; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; LEPTIN; MELANIN CONCENTRATING HORMONE; METFORMIN; NEUROPEPTIDE Y; PROOPIOMELANOCORTIN; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; DIABETIC NEUROPATHY; DIET THERAPY; DRUG TARGETING; ENERGY EXPENDITURE; ENZYME REPRESSION; FATTY ACID BLOOD LEVEL; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HYPERTENSION; INSULIN BLOOD LEVEL; LIFE EXPECTANCY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; RAT; RAT STRAIN; RISK FACTOR; SUSTAINED DRUG RELEASE; WEIGHT REDUCTION;

ANIMALS; ANTI-OBESITY AGENTS; DISEASE MODELS, ANIMAL; HUMANS; LIPID METABOLISM; METFORMIN; MULTIENZYME COMPLEXES; OBESITY; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, INBRED OLETF; RATS, SPRAGUE-DAWLEY; THIOCTIC ACID;

EID: 10344246061     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.13.12.1641     Document Type: Article

References (11)

1. KIM M-S, PARK J-Y, NAMKOONG C et al.: Anti-obesity effect of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein. Nat. Med. (2004) 10:727-733.
2. PEETERS A, BARENDREGT JJ, WILLEKENS F et al.: Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann. Intern. Med. (2003) 138:24-42.
3. HARDIE DG: The AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology (2003) 144 5179-5183.
4. ANDERSSON U, FILIPSSON K, ABBOTT CR et al: AMP-activated protein kinase plays a role in the control of food intake. J. Biol. Chem. (2004) 279:12005-12008.
5. MINOKOSHI Y, ALQUIER T, FURUKAWA N et al.: AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature (2004) 428:569-574.
6. MUSI N, HIRSHMAN MF, NYGREN J et al.: Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with Type 2 diabetes. Diabetes (2002) 51:2074-2081.
7. JACOB S, STREEPER RS, FOGT DL et al.: The antioxidant α-lipoic acid enhances insulin-stimulated metabolism in insulin-resistant rat skeletal muscle. Diabetes (1996) 45 1024-1029.
8. EASON RC, ARCHER HE, AKHTAR S, BAILEY CJ: Lipoic acid increases glucose uptake by skeletal muscles of obese diabetic ob /ob mice. Diabetes Obes. Metab. (2002) 4:29-35.
9. BITAR MS, WAHID S, PILCHER SM, AL-SALEH E, AL-MULLA F: α-Lipoic acid mitigates insulin resistance in Goto-Kakizaki rats. Horm. Metab. Res. (2004) 36:542-549.
10. ZIEGLER D, HANEFELD M, RUHNAU KJ et al.: Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant α-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study). Diabetologia (1995) 38:1425-1433.
11. BERNKOP-SCHNURCH A, REICH-ROHRWIG E, MARSCHULTZ M, SCHUHBAUER M, KRATZEL M: Development of a sustained release dosage form for α-lipoic acid. II. Evaluation in human volunteers. Drug Dev. Ind. Pharm. (2004) 30:35-42.