Integrin specificity of the cyclic Arg-Gly-Asp motif and its role in integrin-targeted gene transfer

Biotechnology and Applied Biochemistry

Volumn 40, Issue 3, 2004, Pages 281-290

  Wittekindt, Carsten ^a   Böttger, Michael ^b   Höltje, Hans Dieter ^a   Schäfer Korting, Monika ^c   Cartier, Régis ^b   Haberland, Annekathrin ^c  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Arg Gly Asp motif; Gene transfer; Integrin; Molecular modelling; S2 bridged cyclic Arg Gly Asp containing peptide (cRGD)

Indexed keywords

BIOCHEMISTRY; CELLS; COMPLEXATION; COMPUTATIONAL METHODS; CONDENSATION; DNA SEQUENCES; POLYETHYLENES; VIRUSES;

ADENOVIRUSES; COMPUTATIONAL DOCKING; DNA CARRIERS; TRANSFECTION;

GENE TRANSFER;

ARGINYLGLYCYLASPARTIC ACID; INTEGRIN; LIPOSOME; PEPTIDE; POLYCATION; POLYETHYLENEIMINE; POLYLYSINE; POLYVINYL DERIVATIVE; POLYVINYL SULFATE; PROTEIN; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ADENOVIRUS; ARTICLE; CELL AGGREGATION; COMPLEX FORMATION; DNA PURIFICATION; DNA SEQUENCE; GENE TARGETING; GENE TRANSFER; GENETIC TRANSFECTION; MOLECULAR MODEL; PHYSICAL CHEMISTRY; PROTEIN FUNCTION;

BINDING SITES; CELL ADHESION; CELL LINE; COMPUTER SIMULATION; DNA; ENDOTHELIAL CELLS; GENE TARGETING; GENETIC VECTORS; HUMANS; INTEGRIN ALPHAVBETA3; MODELS, CHEMICAL; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEIN BINDING; SENSITIVITY AND SPECIFICITY; TRANSFECTION;

ACRONICTA LEPORINA; ADENOVIRIDAE;

EID: 10344244470     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20030206     Document Type: Article

References (39)

1. Wu, G. and Wu, C. H. (1987) J. Biol. Chem. 262, 4429-4432
2. Wagner, E., Zenke, M., Cotten, M., Beug, H. and Birnstiel, M. L. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 3410-3414
3. Kircheis, R., Kichler, A., Wallner, G., Kursa, M., Ogris, M., Felzmann, T., Buchberger, M. and Wagner, E. (1997) Gene Ther. 4, 409-418
4. Kim, J. S., Maruyama, A., Akaike, T. and Kim, S. W. (1998) Pharm. Res. 15, 116-121
5. Collins, L., Gustafsson, K. and Fabre, J. W. (2000) Transplantation 69, 1041-1050
6. Hart, S. L., Harbottle, R. P., Cooper, R., Miller, A., Williamson, R. and Coutelle, C. (1995) Gene Ther 2, 552-554
7. Hood, J. D., Bednarski, M., Frausto, R., Guccione, S., Reisfeld, R. A., Xiang, R. and Cheresh, D. A. (2002) Science 296, 2404-2407
8. Remy, J. S., Kichler, A., Mordvinov, V., Schuber F. and Behr, J. P. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 1744-1748
9. Tros de Ilarduya, C. and Düzgünes, N. (2000) Biochim. Biophys. Acta 1463, 333-342
10. Haberland, A., Zaitsev, S., Dallüge, R., Schneider, M., Zastrow, H., Sukhorukov, G. B., Vorob'ev, V. I. and Böttger, M. (2003) Biol. Membrane 20, 278-287
11. Xiong, J.-P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S. L. and Arnaout, M. A. (2002) Science 296, 151-155
12. Schnorrenberg, G. and Gerhardt, H. (1989) Tetrahedron 45, 7759-7764
13. Atherton, E. and Sheppard, R. C. (1989) Solid Phase Synthesis: A Practical Approach, IRL Press, Oxford
14. Karas, M. and Hillenkamp, F. (1988) Anal. Chem. 60, 2299-2304
15. Weiner, S. J., Kollman, P. A., Case, D. A., Singh, U. C., Ghio, C., Alagona, G., Profeta, S. and Weiner, P. J. (1984) J. Am. Chem. Soc. 106, 765-784
16. Morris, G. M., Goodsell, D. S., Huey, R. and Olson, A. J. (1996) J. Comput. Aided Mol. Des. 10, 293-304
17. GRID v. 21, Molecular Discovery Ltd., Oxford, U.K.
18. Lindahl, E., Hess, B. and van der Spoel, D. (2001) J. Mol. Mod. 7, 306-317
19. Harbottle, R. P., Cooper, R. G., Hart, S. L., Ladhoff, A., McKay, T., Knight, A. M., Wagner, E., Miller, A. D. and Coutelle, C. (1998) Hum. Gene Ther 9, 1037-1047
20. Marinelli, L., Lavecchia, A., Gottschalk, K.-E., Novellino, E. and Kessler, H. (2003) J. Med. Chem. 46, 4393-4404
21. Schaffner, P. and Dard, P. P. (2003) Cell. Mol. Life Sci. 60, 119-132
22. Hart, S. L., Collins, L., Gustafsson, K. and Farbre, J. W. (1997) Gene Ther. 4, 1225-1230
23. Elefteriou, F., Exposito, J. Y., Garrone, R. and Lethias, C. (1999) Eur. J. Biochem. 263, 840-848
24. Scott, E. S., Wiseman, J. W., Evans, M. J. and Colledge, W. H. (2001) J. Gene Med. 3, 125-134
25. Trubetskoy, V. S., Loomis, A., Hagstrom, J. E., Budker, V. G. and Wolff, J. A. (1999) Nucleic Acids Res. 27, 3090-3095
26. Lucius, H., Haberland, A., Zaitsev, S., Dallüge, R., Schneider, M. and Böttger, M. (2001) Mol. Biol. Rep. 28, 157-165
27. Emi, N., Kidoaki, S., Yoshikawa, K. and Saito, H. (1997) Biochim. Biophys. Res. Commun. 231, 421-424
28. Niidome, T., Ohmori, N., Ichinose, A., Wada, A., Mihara, H., Hirayama, T. and Aoyagi, H. (1997) J. Biol. Chem. 272, 15307-15312
29. Kwoh, D. Y., Coffin, C. C., Lollo, C. P., Jovenal, J., Banaszcyk, M. G., Mullen, P., Phillips, A., Amini, J., Fabrycki, R. M., Bartholomew, R. M. et al. (1999) Biochem. Biophys. Acta 1444, 171-190
30. Dallüge, R., Haberland, A., Zaitsev, S., Schneider, M., Zastrow, H., Sukhorukov, G. and Böttger, M. (2002) Biochim. Biophys. Acta 1576, 45-52
31. Haberland, A., Dallüge, R., Zaitsev, S., Stahn, R. and Böttger, M. (1999) Somat. Cell Mol. Genet. 25, 237-245
32. Koivunen, E., Gay, D. A. and Ruoslahti, E. (1993) J. Biol. Chem. 268, 20205-20210
33. Ruoslahti, E. (1996) Annu. Rev. Cell. Dev. Biol. 12, 697-715
34. Smith, L. L. and Giachelli, C. M. (1998) Exp. Cell. Res. 242, 351-360
35. Erbacher, P., Remy, J. S. and Behr, J. P. (1999) Gene Ther. 6, 138-145
36. Schraa, A. J., Kok, R. J., Berendsen, A. D., Moorlag, H. E., Bos, E. J., Meijer, D. K. F., de Leij, L. F. M. H. and Molema, G. (2002) J. Controlled Release 83, 241-251
37. Lee, L. K., Siapati, E., Jenkins, R. G., McAnulty, R. J., Hart, S. L. and Shamlou, P. A. (2003) Med. Sci. Monit. 9, BR54-BR61
38. Sukhorukov, G. B., Donath, E., Davis, S., Lichtenfeld, H., Caruso, F., Popov, V. I. and Möhwald, H. (1998) Polym. Adv. Technol. 9, 759-767
39. Tubetskoy, V. S., Wong, S. C., Subbotin, V., Budker, V. G., Loomis, A., Hagstrom, J. E. and Wolff, J. A. (2003) Gene Ther. 10, 261-271