Electrospray mass spectrometry of a series of mixed nitrido 99gTc-heterocomplexes conjugated with bio-active molecules

European Journal of Mass Spectrometry

Volumn 10, Issue 5, 2004, Pages 605-611

  Tubaro, Michela ^a   Marotta, Ester ^a   Tisato, Francesco ^b   Bolzati, Cristina ^b   Porchia, Marina ^b   Refosco, Fiorenzo ^b   Tomasin, Patrizia ^b   Cavazza Ceccato, Mario ^c   Traldi, Pietro ^a  

^a CNR Consiglio Nazionale delle Ricerche   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

Bio active molecules; Collisionally induced decomposition; Electrospray mass spectrometry; Radiopharmaceuticals; Technetium

Indexed keywords

CYSTEINE; PHOSPHINE; RADIOPHARMACEUTICAL AGENT; TECHNETIUM;

ARTICLE; BINDING AFFINITY; CHEMICAL PROCEDURES; CHEMICAL REACTION; DECOMPOSITION; ELECTROSPRAY MASS SPECTROMETRY; REACTION ANALYSIS;

BIOTIN; CYSTEINE; NITROGEN COMPOUNDS; PIPERAZINES; RADIOISOTOPES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TECHNETIUM; TECHNETIUM COMPOUNDS;

EID: 10044293918     PISSN: 14690667     EISSN: None     Source Type: Journal    
DOI: 10.1255/ejms.677     Document Type: Article

References (18)

1. S. Jurisson, D. Berning, W. Jia and D.S. Ma, "Coordination Compounds in nuclear medicine", Chem. Rev. 93, 1137 (1993).
2. P.J. Blower and S. Prakash, "The chemistry of rhenium in nuclear medicine", Perspective on Bioinorganic Chemistry, 4, 91 (1999).
3. S. Jurisson and J.D. Lydon, "Potential technetium small molecule radiopharmaceuticals", Chem. Rev. 99, 2205 (1999).
4. S. Liu and D.S. Edwards, "99mTc-Labeled small peptides as diagnostic radiopharmaceuticals", Chem. Rev. 99, 2235 (1999).
5. E. Deutsch, K. Libson and J.L. Vanderheyden, Technetium and rhenium and other metals in Chemistry and Nuclear Medicine - III, Ed by M. Nicolini, G. Bandoli and U. Mazzi. Cortina International, Verona, Italy, p. 13 (1989).
6. F. Tisato, C. Bolzati, M. Porchia and F. Refosco, "Contribution of electrospray mass spectrometry for the characterization, design, and development of nitrido technetium and rhenium heterocomplexes as potential radiopharmaceuticals", Mass Spectrom. Rev. 23, 309 (2004).
7. E. Marotta, F. Tisato, F. Refosco, C. Bolzati, M. Porchia and P. Traldi, "Electrospray mass spectrometry in the structural characterization of a mixed nitrido-Tc heterocomplex of interest for myocardial imaging", Rapid Commun. Mass Spectrom. 17, 1225 (2003).
8. B. Johannsen, R. Berger, P. Brust, H.J. Pietzsch, M. Scheunemann, S. Seifert, H. Spies and R. Syher, "Structural modification of receptor-binding technetium-99m complexes in order to improve brain uptake", Eur. J. Nucl. Med. 24, 316 (1997).
9. + in bioorganometallic chemistry: design, structure, and in vitro affinity of a 5HT1A receptor and the alfal-adrenergic receptor", J. Am. Chem. Soc. 121, 6076 (1999).
10. G. Paganelli, P. Magnani, F. Zito, E. Villa, F. Sudati, L. Lopalco, C. Rossetti, M. Malcoviti, F. Chiolerio and E. Seccamani, "Three-step monoclonal antibody tumor targeting in carcinoembryonic antigen-positive patients", Cancer Res. 51, 5960 (1991).
11. 99mTc labeled biotin conjugate in a tumor 'pretargeting' approach with monoclonal antibodies", Angew. Chem. Int. Ed. 31, 1507 (1992).
12. 2+ (PXP = diphosphine ligand). A novel tool for the selective labelling of small molecules", J. Am. Chem. Soc. 121, 11468 (1999).
13. 2+ metal fragment: a technetium-nitrido synthon for use with biologically active molecules. The N-(2-Methoxyphenyl)piperazyl-cysteine analogues as examples", Bioconjugate Chem. 14, 1231 (2003).
14. 2+ (PXP = Diphosphine Ligand)", Bioconjugate Chem. 12, 1035 (2001).
15. F. Tisato and T. Maina, unpublished data.
16. B.A. Nock, T. Maina, E. Malagò, A. Duatti, M. Porchia, F. Refosco and F. Tisato, in Technetium and rhenium and other metals in Chemistry and Nuclear Medicine - VI, Ed by M. Nicolini and U. Mazzi. SG Editoriali, Padova, Italy, p. 479 (2002).
17. M. Karni and A. Mandelbaum, "The even electron rule", Org. Mass Spectrom. 15, 53 (1980).
18. M. Tubaro, E. Marotta, P. Traldi, C. Bolzati, M. Porchia, F. Refosco and F. Tisato, "ESI/MS in the structural characterisation of some nitrido-Re heterocomplexes", Int. J. Mass Spectrom. 232, 239 (2004).