Changes in rat lens proteins and glutathione reductase activity with advancing age

International Journal for Vitamin and Nutrition Research

Volumn 74, Issue 5, 2004, Pages 329-333

  Katakura, Kumiko ^a   Kishida, Kesa ^a   Hirano, Hiroko ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Aging; Crystallins; Gene expression; Glutathione reductase; Lenses; PAD; Protein; Rat

Indexed keywords

FLAVINE ADENINE NUCLEOTIDE; GLUTATHIONE REDUCTASE; LENS PROTEIN; MESSENGER RNA;

AGE; AGING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; MALE; NONHUMAN; RAT;

AGING; ANIMALS; BODY WEIGHT; CRYSTALLINS; FLAVIN-ADENINE DINUCLEOTIDE; GENE EXPRESSION; GLUTATHIONE REDUCTASE; LENS, CRYSTALLINE; ORGAN SIZE; RATS; RNA, MESSENGER; SOLUBILITY; WATER;

ANIMALIA;

EID: 10044249973     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831.74.5.329     Document Type: Article

References (22)

1. Iwata, S. (1984) Biochemistry of the lens. Atarasii Ganka. J. Eye 1, 19-25.
2. Iwata, S. (1980) Senile cataract and the glutathione. Taisha. J. Metabolism 17, 2173-2184.
3. Anderson, E.I., Wright, D.D. and Spector, A. (1979) The state of sulfhydryl groups in normal and cataractous human lens proteins. II. Cortical and nuclear regions. Exp. Eye Res. 29, 233-243.
4. Anderson, E. I. and Spector, A. (1978) The state of sulfhydryl groups in normal and cataractous human lens proteins. I. Nuclear region. Exp. Eye Res. 26, 407-417.
5. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275.
6. Rogers, K.M. and Augusteyn, R.C. (1978) Glutathione reductase in normal and cataractous human lenses. Exp. Eye Res. 27, 719-721.
7. Tillotson, J. A. and Baker, E.M. (1972) An enzymatic measurement of the riboflavin status in man. Am. J. Clin. Nutr. 25, 425-431.
8. 2 deficient rats. Current Eye Res. 3, 663-665.
9. Hustad, S., McKinley, M.C., McNulty, H., Schneede, J., Strain, J.J., Scott, J.M. and Ueland, P.M. (2002) Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation. Clin. Chem. 48, 1571-1577.
10. Harvey, J.W., Stockham, S.L., Scott, M.A., Johnson, P.J., Donald, J.J. and Chandler, C.J. (2003) Methemoglobinemia and eccentrocytosis in equine erythrocyte flavin adenine dinucleotide deficiency. Vet Pathol. 40, 632-642.
11. Hirano, H., Shirakura, Y., Murakami, H. and Ono, S. (1994) Change in lenticular water-soluble protein fraction of the rat with aging. Atarasii Ganka. J. Eye 11, 621-623.
12. Campisi, A., Di Giacomo, C., Russo, A., Sorrenti, V., Vanella, G., Acquaviva, R., Li Volti, G. and Vanella, A. (1999) Antioxidant systems in rat lens as a function of age: Effect of chronic administration of vitamin E and ascorbate. Aging Clin. Exp. Res. 11, 39-43.
13. Kamei, A. (1993) Glutathione levels of the human crystalline lens in aging and its antioxidant effect against the oxidation of lens proteins. Biol. Pharm. Bull. 16, 870-875.
14. Horiuchi, S., Hirano, H. and Ono, S. (1984) Reduced and oxidized glutathione concentrations in the lenses of riboflavin-deficient rats. J. Nutr. Sci. Vitaminol. 30, 401-403.
15. Cherian, M., Smith J.B., Jiang, X.-Y. and Abraham, B.C. (1999) Intrapolypeptide disulfides in human αA-crystallin and their effect on chaperone-like function. Mol. Cell. Biochem. 199, 163-167.
16. 2-Dependent NADH oxidation activity in senile cataractous human lens: Its relation to glutathione redox cycle. Jpn. J. Ophthalmol. 34, 188-195.
17. Yu, N.-T., Denagel, D.C., Pruett, P.L. and Kuck Jr., J.F.R. (1985) Disulfide bond formation in the eye lens. Proc. Natl. Acad. Sci. USA. 82, 7965-7968.
18. Ono, S., Oikawa, K., Hirano, H. and Obara, Y. (1986) Effects of aging on the formation of ester forms of riboflavin in the rat lens. Internat. J. Vit. Nutr. Res. 56, 259-262.
19. Ono, S., Hirano, H. and Sato, Y. (1982) Formation of flavin adenine dinucleotide and flavin mononucleotide by lens homogenate. Exp. Eye Res. 34, 297-301.
20. Ono, S., Hirano, H., Hamajima, S. and Horiuchi, S. (1981) Effects of riboflavin deficiency on the synthesis of ester forms of riboflavin in the rat lens. J. Nutr. Sci. Vitaminol. 27, 599-604.
21. Linetsky, M., Hill, J.M.W., Chemoganskiy, V.G., Hu, F. and Ortwerth, B.J. (2003) Studies on the mechanism of the UVA light-dependent loss of glutathione reductase activity in human lenses. Invest. Ophthalmol. Vis. Sci. 44, 3920-3926.
22. Ruotolo, R., Grassi, F., Percudani, R., Rivetti, C., Martorana, D., Maraini, G. and Ottonello, S. (2003) Gene expression profiling in human age-related nuclear cataract. Mol. Vis. 9, 538-548.