Methemoglobinemia and eccentrocytosis in equine erythrocyte flavin adenine dinucleotide deficiency

Veterinary Pathology

Volumn 40, Issue 6, 2003, Pages 632-642

  Harvey, J W ^a   Stockham, S L ^b,d   Scott, M A ^b,e   Johnson, P J ^b   Donald, J J ^b,f   Chandler, C J ^c  

^a University of Florida College of Veterinary Medicine   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d KANSAS STATE UNIVERSITY   (United States)

^e MICHIGAN STATE UNIVERSITY   (United States)

^f Alpha Scientific Ltd   (New Zealand)

Author keywords

Cytochrome b5; Eccentrocytes; Erythrocytes; FAD; Flavin adenine dinucleotide; Glutathione reductase deficiency; Methemoglobinemia; Reductase deficiency; Riboflavin

Indexed keywords

CYTOCHROME B5 REDUCTASE; FLAVINE ADENINE NUCLEOTIDE; GLUTATHIONE; GLUTATHIONE REDUCTASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; CYTOCHROME REDUCTASE; RIBOFLAVIN;

ARTICLE; BIOCHEMISTRY; CLINICAL FEATURE; CYTOPATHOLOGY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME DEFICIENCY; ERYTHROCYTOSIS; FLAVIN ADENINE DINUCLEOTIDE DEFICIENCY; HORSE DISEASE; LABORATORY TEST; METHEMOGLOBINEMIA; NONHUMAN; VITAMIN DEFICIENCY; VITAMIN METABOLISM; ANIMAL; ANIMAL DISEASE; BLOOD; CHEMISTRY; DRUG EFFECT; ELECTRON MICROSCOPY; ENZYMOLOGY; ERYTHROCYTE; HORSE; METABOLISM; NEUTROPHIL; PATHOPHYSIOLOGY; ULTRASTRUCTURE;

ANIMALIA; EQUIDAE; EQUUS CABALLUS;

ANIMALS; CYTOCHROME REDUCTASES; ERYTHROCYTES; FLAVIN-ADENINE DINUCLEOTIDE; GLUTATHIONE REDUCTASE; HORSE DISEASES; HORSES; METHEMOGLOBINEMIA; MICROSCOPY, ELECTRON; NADP; NEUTROPHILS; RIBOFLAVIN;

EID: 1542706086     PISSN: 03009858     EISSN: None     Source Type: Journal    
DOI: 10.1354/vp.40-6-632     Document Type: Article

References (50)

1. Agar NS, Gruca M, Harley JD: Studies on glucose-6-phosphate dehydrogenase, glutathione reductase and regeneration of reduced glutathione in the red blood cells of various mammalian species. Aust J Exp Biol Med Sci 52:607-614, 1974
2. Ajmar F, Gaetani G, Garre C, Bianchi G, Salvidio E: Effect of primaquine on erythrocytes with NADH-methaemoglobin reductase deficiency and low glutathione reductase activity. Br J Haematol 23:333-341, 1972
3. Anderson BB, Giuberti M, Perry GM, Salsini G, Casadio I, Vullo C: Low red blood cell glutathione reductase and pyridoxine phosphate oxidase activities not related to dietary riboflavin: selection by malaria? Am J Clin Nutr 57:666-672, 1993
4. Beutler E: Effect of flavin compounds on glutathione reductase activity: in vivo and in vitro studies. J Clin Invest 48:1957-1966, 1969
5. Beutler E: Red Cell Metabolism. A Manual of Biochemical Methods, 3rd ed. Grune & Stratton, Orlando, FL, 1984
6. Board PG, Pidcock ME: Methaemoglobinaemia resulting from heterozygosity of two NADH-methaemoglobin reductase variants: characterization as NADH-ferricyanide reductase. Br J Haematol 47:361-370, 1981
7. Christopher MM: Relation of endogenous Heinz bodies to disease and anemia in cats: 120 cases (1978-1987). J Am Vet Med Assoc 194:1089-1095, 1989
8. Christopher MM: Hematologic complications of diabetes mellitus. Vet Clin North Am Small Anim Pract 25:625-637, 1995
9. Constantinescu A, Pick U, Handelman GJ, Haramaki N, Han D, Podda M, Tritschler HJ, Packer L: Reduction and transport of lipoic acid by human erythrocytes. Biochem Pharmacol 50:253-261, 1995
10. Della Rovere F, Granata A, Saija A, Broccio M, Tomaino F, Zirilli A, De Caridi G, Broccio G: -SH groups and glutathione in cancer patient's blood. Anticancer Res 20: 1595-1598, 2000
11. Dixon PM, McPherson EA: Familial methaemoglobinaemia and haemolytic anaemia in the horse associated with decreased erythrocytic glutathione reductase and glutathione. Equine Vet J 9:198-201, 1977
12. Dror Y, Stern F, Komarnitsky M: Optimal and stable conditions for the determination of erythrocyte glutathione reductase activation coefficient to evaluate riboflavin status. Int J Vitam Nutr Res 64:257-262, 1994
13. Eda S, Kikugawa K, Beppu M: Oxidatively damaged erythrocytes are recognized by membrane proteins of macrophages. Free Radic Res 27:23-30, 1997
14. Fischer TM: Transcellular cross bonding of red blood cell membrane. Biochim Biophys Acta 861:277-286, 1986
15. Fischer TM, Meloni T, Pescarmona GP, Arese P: Membrane cross bonding in red cells in favic crises: a missing link in the mechanism of extravascular haemolysis. Br J Haematol 59:159-169, 1985
16. Floridi A, Palmerini CA, Fini C, Pupita M, Fidanza F: High performance liquid chromatographic analysis of flavin adenine dinucleotide in whole blood. Int J Vitam Nutr Res 55:187-191, 1985
17. Gaetani GF, Garre C, Ajmar F, Bianchi GL: Influence of riboflavin and of erythrocyte stroma on glutathione reductase activity in normal, glucose 6 phosphate dehydrogenase deficient and low glutathione reductase individuals. Biomedicine 19:469-474, 1973
18. Harvey JW: The erythrocyte: physiology, metabolism and biochemical disorders. In: Clinical Biochemistry of Domestic Animals, ed. Kaneko JJ, Harvey JW, and Bruss ML, 5th ed., pp. 157-203. Academic Press, San Diego, CA, 1997
19. Harvey JW: Hereditary methemoglobinemia. In: Schalm's Veterinary Hematology, ed. Feldman BF, Zinkl JG, and Jain NC, 5th ed., pp. 1008-1011. Lippincott Williams & Wilkins, Philadelphia, PA, 2000
20. Harvey JW: Atlas of Veterinary Hematology. Blood and Bone Marrow of Domestic Animals, pp. 1-228. WB Saunders, Philadelphia, PA, 2001
21. Harvey JW, Kaneko JJ: Mammalian erythrocyte glutathione reductase: kinetic constants and saturation with cofactor. Am J Vet Res 36:1511-1513, 1975
22. Harvey JW, Kaneko JJ: Mammalian erythrocyte metabolism and oxidant drugs. Toxicol Appl Pharmacol 42: 253-261, 1977
23. Harvey JW, King RR, Berry CR, Blue JT: Methaemoglobin reductase deficiency in dogs. Comp Haematol Int 1:55-59, 1991
24. Harvey JW, Sameck JH, Burgard FJ: Benzocaine-induced methemoglobinemia in dogs. J Am Vet Med Assoc 175:1171-1175, 1979
25. 5 reductase gene. Br J Haematol 103:922-930, 1998
26. Hirano M, Matsuki T, Tanishima K, Takeshita M, Shimizu S, Nagamura Y, Yoneyama Y: Congenital methaemoglobinaemia due to NADH methemoglobin reductase deficiency: successful treatment with oral riboflavin. Br J Haematol 47:353-359, 1981
27. Jansen G, Koenderman L, Rijksen G, Cats BP, Staal GEJ: Characteristics of hexokinase, pyruvate kinase, and glucose-6-phosphate dehydrogenase during adult and neonatal reticulocyte maturation. Am J Hematol 20:203-215, 1985
28. Klatt P, Lamas S: Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress. Eur J Biochem 267:4928-4944, 2000
29. Levin G, Cogan U, Levy Y, Mokady S: Riboflavin deficiency and the function and fluidity of rat erythrocyte membranes. J Nutr 120:857-861, 1990
30. Loos H, Roos D, Weening R, Houwerzijl J: Familial deficiency of glutathione reductase in human blood cells. Blood 48:53-62, 1976
31. Mahaffey E, Smith JE: Species differences in erythrocyte glutathione reduction rates after oxidation with t-butyl hydroperoxide. Int J Biochem 6:853-854, 1975
32. Mandula B, Beutler E: Synthesis of riboflavin nucleotides by mature human erythrocytes. Blood 36:491-499, 1970
33. Mansfield E, Sensabaugh GF: Red cell phosphatase. Prog Clin Biol Res 21:233-237, 1978
34. Mansouri A, Lurie AA: Methemoglobinemia. Am J Hematol 42:7-12, 1993
35. Nicolaisen K, Rogers LE: Erythrocyte NADH-methemoglobin reductase activity in experimental riboflavin deficiency. Experientia 28:263-264, 1972
36. Nonneman D, Stockham SL, Shibuya H, Messer NT, Johnson GS: A missense mutation in the glucose-6-phosphate dehydrogenase gene associated with hemolytic anemia in an American saddlebred horse. Blood 82(Suppl 1):466a, 1993 [Abstract]
37. Paniker NV, Srivastava SK, Beutler E: Glutathione metabolism of the red cells. Effect of glutathione reductase deficiency on the stimulation of hexose monophosphate shunt under oxidative stress. Biochim Biophys Acta 215: 456-460, 1970
38. Perry GM, Anderson BB: Utilization of red-cell FAD by methaemoglobin reductases at the expense of glutathione reductase in heterozygous beta-thalassaemia. Eur J Haematol 46:290-295, 1991
39. Prins HK, Loos JA: Glutathione. In: Biochemical Methods in Red Cell Genetics, ed. Yunis JJ, pp. 1-49. Academic Press, New York, NY, 1969
40. Smith JE, Agar NS: The effect of phlebotomy on canine erythrocyte metabolism. Res Vet Sci 18:231-236, 1975
41. 1H spin echo NMR. Clin Chim Acta 270:115-124, 1998
42. Srivastava SK, Beutler E: The transport of oxidized glutathione from the erythrocytes of various species in the presence of chromate. Biochem J 114:833-837, 1969
43. Stockham SL, Harvey JW, Kinden DA: Equine glucose-6-phosphate dehydrogenase deficiency. Vet Pathol 31: 518-527, 1994
44. Wagner TC, Scott MD: Single extraction method for the spectrophotometric quantification of oxidized and reduced pyridine nucleotides in erythrocytes. Anal Biochem 222:417-426, 1994
45. Weiss DJ, Aird B, Murtaugh MP: Neutrophil-induced immunoglobulin binding to erythrocytes involves proteolytic and oxidative injury. J Leukoc Biol 51:19-23, 1992
46. Weitzman SA, Gordon LI: Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis. Blood 76:655-663, 1990
47. Yawata Y, Tanaka KR: Regulatory mechanism of glutathione reductase activity in human red cells. Blood 43: 99-109, 1974
48. Yubisui T, Matsuki T, Tanishima K, Takeshita M, Yoneyama Y: NADPH-flavin reductase in human erythrocytes and the reduction of methemoglobin through flavin by the enzyme. Biochem Biophys Res Commun 76:174-182, 1977
49. Zempleni J, Link G, Kubler W: The transport of thiamine, riboflavin, and pyridoxal 5′-phosphate by human placenta. Int J Vitam Nutr Res 62:165-172, 1992
50. Zerez CR, Lee SJ, Tanaka KR: Spectrophotometric determination of oxidized and reduced pyridine nucleotides in erythrocytes using a single extraction procedure. Anal Biochem 164:367-373, 1987