Protein kinase C activation inhibits eosinophil degranulation through stimulation of intracellular cAMP production

British Journal of Pharmacology

Volumn 143, Issue 6, 2004, Pages 725-732

  Ezeamuzie, Charles I ^a   Taslim, Najla ^a  

^a KUWAIT UNIVERSITY   (Kuwait)

Author keywords

3 ,5 cyclic monophosphate; Cyclic adenosine; Degranulation; Eosinophils; Phorbol ester; Protein kinase C

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 4ALPHA PHORBOL 13 ACETATE 12 MYRISTATE; COMPLEMENT COMPONENT C5A; CYCLIC AMP; HISTAMINE; ISOENZYME; MYRISTIC ACID DERIVATIVE; PEROXIDASE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHODIESTERASE INHIBITOR; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; ROLIPRAM; ROTTLERIN; UNCLASSIFIED DRUG;

ARTICLE; CELL LEVEL; CHELATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEGRANULATION; DRUG POTENCY; ENZYME ACTIVATION; ENZYME RELEASE; EOSINOPHIL DEGRANULATION; EOSINOPHIL DEGRANULATION INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; WESTERN BLOTTING;

CELL DEGRANULATION; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EOSINOPHILS; HUMANS; INTRACELLULAR FLUID; PROTEIN KINASE C; TETRADECANOYLPHORBOL ACETATE;

EID: 10044248936     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706028     Document Type: Article

References (35)

1. ALI, A., FORD-HUTCHINSON, A.W. & NICHOLSON, D.W. (1994). Activation of protein kinase C down-regulates leukotriene synthase activity and attenuates cysteinyl leukotriene production in an eosinophilic sub-strain of HL-60 cells. J. Immunol., 153, 776-788.
2. BANKERS-FULBRIGHT, J.L., KITA, H., GLEICH, G.J. & O'GRADY, S.M. (2001). Regulation of human eosinophil NADPH oxidase activity: a central role for PKCδ. J. Cell. Physiol., 189, 306-315.
3. CHOI, E.J., WONG, S.T., DITTMAN, A.H. & STORM, D.R. (1993). Phorbol ester stimulation of the type I and type II adenylyl cyclases in whole cells. Biochemistry, 32, 1891-1894.
4. COOPER, D.M.F., MONS, N. & KARPEN, J.W. (1995). Adenylyl cyclases and the interaction between calcium and cAMP signaling. Nature, 374, 421-424.
5. DEKKER, L.V. & PARKER, P.J. (1994). Protein kinase c - a question of specificity. Trends Biochem. Sci., 19, 73-77.
6. EVANS, D.J., LINDSAY, M.A., WEBB, B.L.J., KANKAANRANTA, H., GIEMBYCZ, M.A., O'CONNOR, B.J. & BARNES, P.J. (1999). Expression and activation of protein kinase C-ς in eosinophils after allergen challenge. Am. J. Physiol., 277, L233-L239.
7. 3 receptors on human eosinophils mediate inhibition of degranulation and superoxide anion release. Br. J. Pharmacol., 127, 188-194.
8. GIEMBYCZ, M.A. & LINDSAY, M.A. (1999). Pharmacology of eosinophils. Pharmacol. Rev., 51, 213-340.
9. GLEICH, G.J. & ADOLPHSON, C.R. (1999). The eosinophil and bronchial asthma: evidence for a critical role of eosinophils in pathophysiology. In: Interlukin-5 from Molecule to Drug Target for Asthma, ed. Lenfant C. pp. 1-37. New York: Marcel-Dekker.
10. GSCHWENDT, M., DIETERICH, B., RENNECKE, J., KITTSTEIN, W., MULLER, H.J. & JOHANNES, F.J. (1996). Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett., 392, 77-80.
11. GSCHWENDT, M., MULLER, H.J., KIELBASSA, K., ZANG, R., KITTSTEIN, W., RINCKE, G. & MARKS, F. (1994). Rottlerin, a novel protein kinase inhibitor. Biochem. Biophys. Res. Commun., 199, 93-98.
12. GUSOVSKY, F. & GUTKIND, J.S. (1991). Selective effects of the activation of PKC isozymes on camp accumulation. Mol. Pharmacol., 39, 124-129.
13. HANSEL, T.T., De VRIES, I.J.M., IFF, T., RIS, S., WANDZILAK, M., BETZ, S., BLASER, K. & WALKER, C. (1991). An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils. J. Immunol. Methods, 145, 105-110.
14. JACOBOWITZ, O. & IYENGAR, R. (1994). Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2. Proc. Natl. Acad. Sci. U.S.A., 91, 10630-10634.
15. KAWABE, J., IWAMI, G., EBINA, T., OHNO, S., KATADA, T., UEDA, Y., HOMEY, C.J. & ISHIKAWA, Y. (1994). Differential activation of adenylyl cyclase by protein kinase C iso-enzymes. J. Biol. Chem., 269, 16554-16558.
16. KERNEN, P., WYMANN, M.P., VON TSCHARNER, V., DERANLEAU, D.A., TAI, P.C., SPRY, C.J., DAHINDEN, C.A. & BAGGIOLINI, M. (1991). Shape change, exocytosis and cytosolic calcium changes in stimulated human eosinophils. J. Clin. Invest., 87, 2012-2017.
17. KITA, H., ABU-GHAZALEH, R.I., GLEICH, G.J. & ABRAHAM, R.T. (1991). Regulation of Ig-induced eosinophil degranulation by adenosine 3′,5′-cyclic monophosphate. J. Immunol., 146, 2712-2718.
18. KROEGEL, C., GIEMBYCZ, M.A., MATTHYS, H., WESTWICK, J. & BARNES, P.J. (1994). Modulatory role of protein kinase C on the signal transduction pathway utilized by platelet activating factor in eosinophil activation. Am. J. Respir. Cell Mol. Biol., 11, 593-599.
19. KROEGEL, C., YUKAWA, T., DENT, G., VENGE, P., CHUNG, K.F. & BARNES, P.J. (1989). Stimulation of degranulation from eosinophils by platelet activating factor. J. Immunol., 142, 3518-3526.
20. LAI, H.L., YANG, T.H., MESSING, R.O., CHING, Y.H., LIN, S.C. & CHERN, Y. (1997). Protein kinase c inhibits adenylyl cyclase type VI activity during desensitization of the A2a-adenosine receptor-mediated camp response. J. Biol. Chem., 272, 4970-4977.
21. LIN, W.-W., CHANG, S.-H. & WANG, S.-M. (1999). Roles of atypical protein kinase C in lysophosphatidic acid-induced type II adenylyl cyclase activation in RAW 264.7 macrophages. Br. J. Pharmacol., 128, 1189-1198.
22. LIN, W.-W. & CHEN, B.C. (1998). Distinct isoforms mediate the activation of cPLA2 and adenylyl cyclase by phorbol ester in RAW264.7 macrophages. Br. J. Pharmacol., 125, 1601-1609.
23. LYNCH, O.T., GIEMBYCZ, M.A., BARNES, P.J., HELLEWELL, P.G. & LINDSAY, M.A. (1999). Outside-in' signaling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils. Br. J. Pharmocol., 128, 1149-1158.
24. MARTINY-BARON, G., KAZANIETZ, M.G., MISCHAR, H., BLUMBERG, F.M., KOCHS, G., HUG, H., MARME, D. & SCHACHTELE, C. (1993). Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J. Biol. Chem., 268, 9194-9197.
25. MOTOJIMA, S., FAKUDA, T. & MAKINO, S. (1998). Eosinophil activation in asthma. Lung Biol. Health Dis., 117, 179-204.
26. NISHIZUKA, Y. (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science, 258, 607-613.
27. NISHIZUKA, Y. (1995). Protein kinase C and lipid signaling for sustained cellular responses. FASEB J., 9, 484-496.
28. ROBINSON, C. & CARVER, J.E. (1998). Interactions between eosinophils and the airway epithelium. Lung Biol. Health Dis., 117, 263-286.
29. ROBINSON, D.S. (1999). Interlukin-5 and the interleukin 5 receptor in asthma. Lung Biol. Health Dis., 125, 51-68.
30. SEDGWICK, J.B., GEIGER, K.M. & BUSSE, W.W. (1990). Superoxide generation by hypodense eosinophils from patients with asthma. Am. Rev. Respir. Dis., 142, 120-125.
31. TAKIZAWA, T., KATO, M., SUZUKI, M., TACHIBANA, A., MOTEGI, Y., FUJIU, T., KIMURA, H., ARAKAWA, H., MOCHIZUKI, H., TOKUYAMA, K. & MORIKAWA, A. (2003). Distinct isoforms of PKC are involved in human eosinophil functions induced by platelet activating factor. Int. Arch. Allergy Immunol., 131 (Suppl 1), 15-19.
32. TAUSSIG, R., INIGUEZ-LLUHI, J.A. & GILMAN, A.G. (1993). Inhibition of adenylyl cyclase by Gi alpha. Science, 261, 218-221.
33. TSU, R.C. & WONG, Y.H. (1996). Gi-mediated stimulation of type II adenylyl cyclase is augmented by Gq-coupled receptor activation and phorbol ester treatment. J. Neurosci., 16, 1317-1323.
34. VAN DER BRUGGEN, T. & KOENDERMAN, L. (1996). Signal transduction in eosinophils. Clin. Exp. Allergy, 26, 880-891.
35. YEO, E.J. & EXTON, J.H. (1995). Stimulation of phospholipase D by epidermal growth factor requires protein kinase C activation in Swiss 3T3 cells. J. Biol. Chem., 270, 3980-3988.