Differential linkage of triglyceride and glucose levels on rat chromosome 4 in two segregating rat populations

Folia Biologica

Volumn 49, Issue 6, 2003, Pages 223-226

  Šeda, Ondřej ^a,b,c   Liska F ^a   Krenova D ^a   Kazdova L ^c   Sedova L ^a   Zima, T ^d   Peng, J ^b   Tremblay, J ^c   Kren V ^a,e   Hamet, P ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^c INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE   (Czech Republic)

^d CHARLES UNIVERSITY   (Czech Republic)

^e INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

BN.SHR4; Cd36 FAT; Congenic strain; Insulin resistance syndrome; PD Cub; QTL

Indexed keywords

CD36 ANTIGEN; GLUCOSE; INTERLEUKIN 6; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CARBOHYDRATE METABOLISM; CENTROMERE; CHROMOSOME 4; CHROMOSOME 4Q; CHROMOSOME SEGREGATION; CONTROLLED STUDY; GENETIC LINKAGE; GLUCOSE BLOOD LEVEL; LINKAGE ANALYSIS; LIPID METABOLISM; MALE; METABOLIC SYNDROME X; MORPHOMETRICS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PATHOGENESIS; PHENOTYPE; POPULATION GENETICS; PROMOTER REGION; RAT; RAT STRAIN; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALIA; RODENTIA;

EID: 0942287889     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Aitman, T. J., Glazier, A. M., Wallace, C. A., Cooper, L. D., Norsworthy, P. J., Wahid, F. N., Al-Majali, K. M., Trembling, P. M., Mann, C. J., Shoulders, C. C., Graf, D., St. Lezin, E., Kurtz, T. W., Křen, V., Pravenec, M., Ibrahimi, A., Abumrad, N. A., Stanton, L. W., Scott, J. (1999) Identification of Cd36 (FAT) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat. Genet. 21, 76-83.
2. Bílá, V., Křen, V., Liška, F. (2000) The influence of the genetic background on the interaction of retinoic acid with Lx mutation of the rat. Folia Biol. (Praha) 46, 264-272.
3. Billingham, R. E., Silvers, W. K. (1959) Inbred animals and tissue transplantation immunity. Transplant. Bull. 6, 399-406.
4. Bottger, A., van Lith, H. A., Křen, V., Křenová, D., Bílá, V., Vorlíček, J., Zídek, V., Musilová, A., Zdobinská, M., Wang, J. M., van Zutphen, B. F., Kurtz, T. W., Pravenec, M. (1996) Quantitative trait loci influencing cholesterol and phospholipid phenotypes map to chromosomes that contain genes regulating blood pressure in the spontaneously hypertensive rat. J. Clin. Invest. 98, 856-862.
5. Hajri, T., Han, X. X., Bonen, A., Abumrad, N. A. (2002) Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice. J. Clin. Invest. 109, 1381-1389.
6. Kovacs, P., Kloting, I. (1998) Quantitative trait loci on chromosomes 1 and 4 affect lipid phenotypes in the rat. Arch. Biochem. Biophys. 354, 139-143.
7. Křen, V. (1975) Genetics of the polydactyly-luxate syndrome in the Norway rat, Rattus norvegicus. Acta Univ. Carrol. Med. Praha (Monogr.) 68, 1-103.
8. Křen, V., Křenová, D., Bílá, V., Zdobinská, M., Zídek, V., Pravenec, M. (1996) Recombinant inbred and congenic strains for mapping of genes that are responsible for spontaneous hypertension and other risk factors of cardiovascular disease. Folia Biol. (Praha) 42, 155-158.
9. Manly, K. F., Cudmore, R. H., Meer, J. M. (2001) Map Manager QTX, cross-platform software for genetic mapping. Mam. Genome 12, 930-932.
10. Meigs, J. B., Wilson, P. W., Nathan, D. M., D'Agostino, R. B. Sr., Williams, K., Haffner, S. M. (2003) Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring Studies. Diabetes 52, 2160-2167.
11. Ogino, T., Wei, S., Wei, K., Moralejo, D. H., Kose, H., Mizuno, A., Shima, K., Sasaki, Y., Yamada, T., Matsumoto, K. (2000) Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF. Genomics 70, 19-25.
12. Pravenec, M., Gauguier, D., Schott, J. J., Buard, J., Kren, V., Bila, V., Szpirer, C., Szpirer, J., Wang, J. M., Huang, H., St. Lezin, E., Spence, M. A., Flodman, P., Printz, M., Lathrop, G. M., Vergnaud, G., Kurtz, T. (1995) Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains. J. Clin. Invest. 96, 1973-1978.
13. Pravenec, M., Landa, V., Zidek, V., Musilová A., Křen, V., Kazdová, L., Aitman T. J., Glayier A. M., Ibrahimi A., Abumrad N. A., Qi, N., Wang, J., St. Lezin, E., Kurtz, T. W. (2001) Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. Nat. Genet. 27, 156-158.
14. Reaven, G. M. (1988) Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37, 1595-1607.
15. Šedová, L., Kazdová, L., Šeda, O., Křenová, D., Křen, V. (2000) Rat inbred PD/Cub strain as a model of dyslipidemia and insulin resistance Folia Biol. (Praha) 46, 99-106.
16. Šeda, O., Kazdová, L., Křenová, D., Křen, V. (2002a) Rosiglitazone improves insulin resistance, lipid profile and promotes adiposity in a genetic model of metabolic syndrome X. Folia Biol. (Praha) 48, 237-241.
17. Šeda, O., Šedová, L., Kazdová, L., Křenová, D., Křen, V. (2002b) Metabolic characterization of insulin resistance syndrome feature loci in three Brown Norway-derived congenic strains. Folia Biol. (Praha) 48, 81-88.
18. Šeda, O., Kazdová, L., Křenová, D., Křen, V. (2003a) Rosiglitazone fails to improve hypertriglyceridemia and glucose tolerance in CD36-deficient BN.SHR4 congenic rat strain. Physiol. Genomics 12, 73-78.
19. Šeda, O., Liška, F., Křenová, D., Kazdová, L., Zima, T., Peng, J., Tremblay, J., Křen, V., Hamet, P. (2003b) Genetic determinants of metabolic syndrome in a rodent model: effect of major loci on chromosomes 3, 8 and 17. J. Hypertens. 21, (suppl. 4) S99.
20. Šeda, O., Liška, F., Křenová, D., Kazdová, L., Zima, T., Peng, J., Tremblay, J., Křen, V., Hamet, P. (2003c) Major loci on rat chromosomes 3, 8 and 17 determine body weight, insulin and triglyceride levels in a model of metabolic syndrome. Am. J. Hypertens. 16, (suppl. 1) A229-A230.
21. Vrána, A., Kazdová, L., Dobešová, Z., Kuneš, J., Křen, V., Bílá, V., Štolba, P., Klimeš, I. (1993) Triglyceridemia, glucoregulation, and blood pressure in various rat strains. Effects of