Medullary and Spinal Cord Projections from Cardiovascular Responsive Sites in the Rostral Ventromedial Medulla

Journal of Comparative Neurology

Volumn 469, Issue 3, 2004, Pages 391-412

  Babic, Tanja ^a   Ciriello, John ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Arterial pressure; Cardiovascular regulation; Nucleus ambiguus; Nucleus of the solitary tract; Sympathetic preganglionic neurons; Ventrolateral medulla

Indexed keywords

AMINE; BIOTIN; BIOTINYLATED DEXTRAN AMINE; DEXTRAN; DRUG DERIVATIVE; GLUTAMIC ACID; LEUKOAGGLUTININ; PHYTOHEMAGGLUTININ; PHYTOHEMAGGLUTININ L; UNCLASSIFIED DRUG;

ADOLESCENT; AMBIGUUS NUCLEUS; ANIMAL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; BRAIN COMMISSURE; BRAIN MAPPING; BRAIN NUCLEUS; BRAIN STEM; CARDIOVASCULAR AUTOREGULATION; CHEMICAL LABELING; COMPARATIVE STUDY; CYTOLOGY; DORSOLATERAL FUNICULUS; HEART RATE; INTERMEDIOLATERAL NUCLEUS; IONTOPHORESIS; LATERAL RETICULAR NUCLEUS; MALE; MEDULLA OBLONGATA; METABOLISM; METHODOLOGY; MICROINJECTION; NERVE CELL; NERVE PROJECTION; NERVE TRACT; NONHUMAN; PHYSIOLOGY; PREGANGLIONIC NERVE; PREGANGLIONIC NERVE CELL; PRESSORECEPTOR; PRIORITY JOURNAL; RAT; RAT STRAIN; ROSTRAL LATERAL PARAGIGANTOCELLULAR RETICULAR NUCLEUS; ROSTRAL MAGNOCELLULAR RETICULAR NUCLEUS; ROSTRAL VENTROMEDIAL MEDULLA; SOLITARY TRACT NUCLEUS; SPINAL CORD; STAINING; SUBSTANTIA GELATINOSA; SYMPATHETIC NERVE; TISSUE DISTRIBUTION;

ANIMALS; AUTONOMIC FIBERS, PREGANGLIONIC; BIOTIN; BLOOD PRESSURE; BRAIN MAPPING; DEXTRANS; HEART RATE; IONTOPHORESIS; MALE; MEDULLA OBLONGATA; NEURAL PATHWAYS; NEURONS; PHYTOHEMAGGLUTININS; PLANT PROTEINS; RATS; RATS, WISTAR; SPINAL CORD; STAINING AND LABELING; TISSUE DISTRIBUTION;

EID: 0942276349     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.11024     Document Type: Article

References (79)

1. Aicher SA, Reis DJ. 1997. Gigantocellular vasodepressor area is tonically active and distinct from caudal ventrolateral vasodepressor area. Am J Physiol 272:R731-R742.
2. Aicher SA, Reis DJ, Nicolae R, Milner TA. 1995. Monosynaptic projections from the medullary gigantocellular reticular formation to sympathetic preganglionic neurons in the thoracic spinal cord. J Comp Neurol 363:563-580.
3. Allen GV, Cechetto DF. 1994. Serotoninergic and nonserotoninergic neurons in the medullary raphe system have axon collateral projections to autonomic and somatic cell groups in the medulla and spinal cord. J Comp Neurol 350:357-366.
4. Antal M, Petko M, Polgar E, Heizmann CW, Storm-Mathisen J. 1996. Direct evidence of an extensive Gabaergic innervation of the spinal dorsal horn by fibres descending from the rostral ventromedial medulla. Neurosci 73:509-518.
5. Basbaum AI, Fields HL. 1984. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 7:309-338.
6. Basbaum AI, Clanton CH, Fields HL. 1978. Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems. J Comp Neurol 178:209-224.
7. Basbaum AI, Zahs K, Lord B, Lakos S. 1988. The fiber caliber of 5-HT immunoreactive axons in the dorsolateral funiculus of the spinal cord. Somatosensory Res 5:177-185.
8. Bieger D, Hopkins DA. 1987. Viscerotopic representation of the upper alimentary tract in the medulla oblongata in the rat: the nucleus ambiguus. J Comp Neurol 262:546-562.
9. Bowker RM, Steinbusch HWM, Coulter JD. 1981a. Serotonergic and peptidergic projections to the spinal cord demonstrated by a combined retrograde HRP histochemical and immunocytochemical staining method. Brain Res 211:412-417.
10. Bowker RM, Westlund KN, Coulter JD. 1981b. Origin of serotonergic projections to the spinal cord in rat: an immunocytochemical-retrograde transport study. Brain Res 226:187-199.
11. Casey KL. 1971. Responses of bulboreticular units to somatic stimuli eliciting escape responses in the cat. Int J Neurosci 2:15-28.
12. Ciriello J, Calaresu FR. 1980. Distribution of vagal cardioinhibitory neurons in the medulla of the cat. Am J Physiol 238:R57-R64.
13. Ciriello J, Janssen SA. 1993. Effect of glutamate stimulation of bed nucleus of the stria terminalis on arterial pressure and heart rate. Am J Physiol 265:H1516-H1522.
14. Ciriello J, Caverson MM, Polosa C. 1986. Function of the ventrolateral medulla in the control of the circulation. Brain Res Rev 11:359-391.
15. Ciriello J, Hochstenbach SL, Roder S. 1994. Central projections of baroreceptor and chemoreceptor afferent fibers in the rat. In: Barraco IRA, editor. Nucleus of the solitary tract. Boca Raton, FL: CRC Press. p 35-49.
16. Clark FM, Proudfit HK. 1991. Projections of neurons in the ventromedial medulla to pontine catecholamine cell groups involved in the modulation of nociception. Brain Res 540:105-115.
17. Cox BF, Brody MJ. 1989. Subregions of rostral ventral medulla control arterial pressure and regional hemodynamics. Am J Physiol 257:R635-R640.
18. Dobbins EG, Feldman JL. 1994. Brainstem network controlling descending drive to phrenic motoneurons in rat. J Comp Neurol 347:64-86.
19. Ellenberger HH, Feldman JL. 1990. Brainstem connections of the rostral ventral respiratory group of the rat. Brain Res 513:35-42.
20. Ellenberger HH, Vera PL, Feldman JL, Holets VR. 1992. Multiple putative neuromessenger inputs to the phrenic nucleus in rat. J Chem Neuroanat 5:375-382.
21. Farkas E, Jansen ASP, Loewy AD. 1998. Periaqueductal gray matter input to cardiac-related sympathetic premotor neurons. Brain Res 792:179-192.
22. Feldman JL, Loewy AD, Speck DF. 1985. Projections from the ventral respiratory group to phrenic and intercostal motoneurons in cat: an autoradiographic study. J Neurosci 5:1993-2000.
23. Fields HL, Basbaum AI. 1978. Brainstem control of spinal pain-transmission neurons. Ann Rev Physiol 40:217-248.
24. Gandal CP. 1969. Avian anesthesia. Fed Proc 28:1533-1534.
25. Gebhart GF, Sandkuhler J, Thalhammer JG, Zimmermann M. 1983. Inhibition of spinal nociceptive information by stimulation in midbrain of the cat is blocked by lidocaine microinjected in nucleus raphe magnus and medullary reticular formation. J Neurophysiol 50:446-459.
26. Gerfen CR, Sawchenko PE. 1984. An anterograde neuroanatomical tracing method that shows the detailed morphology of neurons, their axons and terminals: immunohistochemical localization of an axonally transported plant lectin, Phaseolus vulgaris leucoagglutinin (PHA-L). Brain Res 290:219-238.
27. Gray BG, Dostrovsky JO. 1983. Descending inhibitory influences from periaqueductal gray, nucleus raphe magnus, and adjacent reticular formation. I. Effects on lumbar spinal cord nociceptive and non-nociceptive neurons. J Neurophysiol 49:932-947.
28. Groenewegen HJ, Wouterlood FG. 1990. Light and electron microscopic tracing of neuronal connections with Phaseolus vulgaris-leucoagglutinin (PHA-L), and combinations with other neuroanatomical techniques. In: Bjorklund A, Hokfelt T, Wouterlood FG, van den pol AA, editors. Handbook of chemical neuroanatomy, vol. 8. Amsterdam: Elsevier. p 47-124.
29. Groenewegen HJ, Berendse HW, Meredith GE, Haber SN, Voorn P, Wolters JG, Lohman AHM. 1991. Functional anatomy of the ventral limbic system-innervated striatum. In: Wilner P, Scheel-Kruger J, editors. The mesolimbic dopamine system: from motivation to action. Chichester, UK: John Wiley & Sons.
30. Hadziefendic S, Haxhiu MA. 1999. CNS innervation of vagal preganglionic neurons controlling peripheral airways: a transneuronal labeling study using pseudorabies virus. J Autonom Nerv Syst 76:135-145.
31. Hancock MB. 1982. A serotonin-immunoreactive fiber system in the dorsal columns of the spinal cord. Neurosc Lett 31:247-252.
32. Hancock MB, Peveto CA. 1979. Preganglionic neurons in the sacral spinal cord of the rat: an HRP study. Neurosci Lett 11:1-5.
33. Hermann GE, Holmes GM, Rogers RC, Beattie MS, Bresnahan JC. 2003. Descending spinal projections from the rostral gigantocellular reticular nuclei complex. J Comp Neurol 455:210-221.
34. Hokfelt T, Arvidsson U, Cullheim S, Millhorn D, Nicholas AP, Pieribone V, Seroogy K, Ulfhake B. 2000. Multiple messengers in descending serotonin neurons: localization and functional implications. J Chem Neuroanat 18:75-86.
35. Holtman JR Jr, Speck DF. 1994. Substance P immunoreactive projections to the ventral respiratory group in the rat. Peptides 15:803-808.
36. Holtman JR, Marion LJ Speck, DF. 1990. Origin of serotonin-containing projections to the ventral respiratory group in the rat. Neuroscience 37:541-552.
37. Jansen ASP, Wessendorf MW, Loewy AD. 1995. Transneuronal labeling of CNS neuropeptide and monoamine neurons after pseudorabies virus injections into the stellate ganglion. Brain Res 683:1-24.
38. Jiang X, Johnson RR, Burkhalter A. 1993. Visualization of dendritic morphology of cortical projection neurons by retrograde axonal tracing. J Neurosci Meth 50:45-60.
39. Johnson AD, Peoples J, Stronetta RL, Van Bockstaele EJ. 2002. Opioid circuits originating from the nucleus paragiganotcellularis and their potential role in opiate withdrawal. Brain Res 955:72-84.
40. Jones BE, Holmes CJ, Rodriguez-Weiga E, Mainville L. 1991. GABA-synthesizing neurons in the medulla: Their relationship to serotonin-containing and spinally projecting neurons in the rat. J Comp Neurol 313:349-367.
41. Kausz M. 1991. Arrangement of neurons in the medullary reticular formation and raphe projecting to thoracic and sacral segments of the spinal cord in the rat. Anat Embryol 183:151-163.
42. LeBlanc HJ, Gatipon GB. 1974. Medial bulboreticular response to peripherally applied noxious stimuli. Exp Neurol 42:264-273.
43. Loewy AD, McKellar S. 1981. Serotonergic projections from the ventral medulla to the intermediolateral cell column in the rat. Brain Res 211:146-152.
44. Marson L, Platt KB, McKenna KE. 1993. CNS innervation of the penis as revealed by transneuronal transport of pseudorabies virus. Neuroscience 55:263-280.
45. McAllen RM, Spyer KM. 1978. The baroreceptor input to cardiac vagal motoneurones. J Physiol (Lond) 282:365-374.
46. Millhorn DE, Seroogy K, Hokfelt T, Schmued LC, Terenius L, Buchan A, Brown JC. 1987. Neurons of the ventral medulla oblongata that contain both somatostatin and enkephalin immunoreactivities project to nucleus tractus solitarii and spinal cord. Brain Res 424:99-108.
47. Minson JB, Chalmers JP, Caon AC, Renaud B. 1987. Separate areas of rat medulla oblongata with populations of serotonin-and adrenaline-containing neurons alter blood pressure after L-glutamate stimulation. J Autonom Nerv Syst 19:39-50.
48. Miura M, Okada J, Takayama K. 1996. Parapyramidal rostroventromedial medulla as a respiratory rhythm modulator. Neurosci Lett 203:41-44.
49. Nadelhaft I, Booth AM. 1984. The location and morphology of preganglionic neurons and the distribution of visceral afferents from the rat pelvic nerve: a horseradish peroxidase study. J Comp Neurol 226:238-245.
50. Nosaka S, Yamamoto T, Yasunaga K. 1979. Localization of vagal cardioin-hibitory preganglionic neurons within rat brain stem. J Comp Neurol 186:79-92.
51. Nosaka S, Yamamoto T, Tamai S. 1982. Vagal cardiac preganglionic neurons: distribution, cell types, and reflex discharge. Am J Physiol 243: R92-R98.
52. Papka RE, Williams S, Miller KE, Copelin T, Puri P. 1998. CNS location of uterine-related neurons revealed by trans-synaptic tracing with pseudorabies virus and their relation to estrogen receptor-immunoreactive neurons. Neuroscience 84:935-952.
53. Paxinos G, Watson C. 1986. The rat brain in stereotaxic coordinates. New York: Academic Press.
54. Reiner A, Veenman CL, Medina L, Jiao Y, Del Mar N, Honig MG. 2000. Pathway tracing using biotinylated dextran amines. J Neurosci Meth 103:23-37.
55. Romagnano MA, Harshbager RJ, Hamill RW. 1991. Brainstem enkephalinergic projections to spinal autonomic nuclei. J Neurosci 11:3539-3555.
56. Ross CA, Ruggiero DA, Reis DJ. 1981. Afferent projections to cardiovascular portions of the nucleus of the tractus solitarius in the rat. Brain Res 223:402-408.
57. Sasek CA, Helke CJ. 1989. Enkephalin-immunoreactive neuronal projections from the medulla oblongata to the intermediolateral cell column: relationship to substance P-immunoreactive neurons. J Comp Neurol 287:484-494.
58. Sasek CA, Wessendorf MW, Helke CJ. 1990. Evidence for co-existence of thyrotropin-releasing hormone, substance P and serotonin in ventral medullary neurons that project to the intermediolateral cell column in the rat. Neuroscience 35:105-119.
59. Satoh M, Oku R, Akaike A. 1983. Analgesia produced by microinjection of L-glutamate into the rostral Ventromedial bulbar nuclei of the rat and its inhibition by intrathecal adrenergic blocking agents. Brain Res 261:361-364.
60. Schramm LP, Strack AM, Platt KB, Loewy AD. 1993. Peripheral and central pathways regulating the kidney: a study using pseudorabies virus. Brain Res 616:251-262.
61. Smith JC, Morrison DE, Ellenberger HH, Otto MR, Feldman JL. 1989. Brainstem projections to the major respiratory neuron populations in the medulla of the cat. J Comp Neurol 281:69-96.
62. Stornetta RL, Guyenet PG. 1999. Distribution of glutamic acid decarboxylase mRNA-containing neurons in rat medulla projecting to thoracic spinal cord in relation to monoaminergic brainstem neurons. J Comp Neurol 407:367-380.
63. Stuesse SL. 1982. Origins of cardiac vagal preganglionic fibers: a retrograde transport study. Brain Res 236:15-25.
64. Swanson LW. 1992. Brain maps: structure of the rat brain. Amsterdam: Elsevier.
65. Ter Horst GJ, Van den Brink A, Homminga SA, Hautvast RWM, Rakhorst G, Mettenleiter TC, De Jongste MJL, Lie KI, Korf J. 1993. Transneuronal viral labeling of rat heart left ventricle controlling pathways. Neuroreport 4:1307-1310.
66. Ter Horst GJ, Hautvast RWM, De Jongste MJL, Korf J. 1996. Neuroanatomy of cardiac activity-regulating circuitry: A transneuronal retrograde viral labeling study in the rat. Eur J Neurosci 8:2029-2041.
67. Thor KB, Helke CJ. 1987. Serotonin- and substance P-containing projections to the nucleus tractus solitarii of the rat. J Comp Neurol 265:275-293.
68. Varner KJ, Grosskreutz CL, Cox BF, Brody MJ. 1989. Differential regulation of sympathetic nerve activity by lateral and medial subregions of the rostral ventral medulla. Prog Brain Res 8:99-103.
69. Varner KJ, Rutherford SS, Vasquez EC, Brody MJ. 1992. Identification of cardiovascular neurons in the rostral ventromedial medulla in anesthetized rats. Hypertension 19(Suppl. II):II193-197.
70. Veenman CL, Reiner A, Honig MG. 1992. Biotinylated dextran amine as an anterograde tracer for single- and double-label studies. J Neurosci Meth 41:239-254.
71. Veenman CL, Wild JM, Reiner A. 1995. Organization of the avian 'corticostriatal' projection system: a retrograde and anterograde pathway tracing study in pigeons. J Comp Neurol 354:87-126.
72. Westlund KN, Lu Y, Coggeshall RE, Willis WD. 1992. Serotonin is found in myelinated axons of the dorsolateral funiculus in monkeys. Neurosci Lett 141:35-38.
73. Willette RN, Barcas PP, Krieger AJ, Sapru HN. 1983. Vasopressor and depressor areas in the rat medulla. Neuropharmacology 22:1071-1079.
74. Wouterlood FG, Jorritsma-Byham B. 1993. The anterograde neuroanatomical tracer biotinylated dextran amine: comparison with the tracer PHA-L in preparations for electron microscopy. J Neurosci Meth 48:75-87.
75. Yardley CP, Andrade JM, Weaver LC. 1989. Evaluation of cardiovascular control by neurons in the dorsal medulla of rats. J Autonom Nerv Syst 29:1-12.
76. Zagon A. 1995. Internal connections in the rostral ventromedial medulla of the rat. J Autonom Nerv Syst 53:43-56.
77. Zemlan FP, Behbehani MM, Beckstead RM. 1984. Ascending and descending projections from the nucleus reticularis magnocellularis and the nucleus gigantocellulayis: an autoradiographic and horseradish peroxidase study in the rat. Brain Res 292:207-220.
78. Zhuo M, Gebhart GF. 1990. Characterization of descending inhibition and facilitation from nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Pain 42:337-350.
79. Zhuo M, Gebhart GF. 2002. Modulation of noxious and non-noxious spinal mechanical transmission from rostral medial medulla in the rat. J Neurophysiol 88:2928-2941.