A functional erythropoietin receptor is necessary for the action of thrombopoietin on erythroid cells lacking c-mpl

Experimental Hematology

Volumn 32, Issue 2, 2004, Pages 140-148

  Rouleau, Cecile ^a   Cui, Kunyuan ^a   Feldman, Laurie ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; MESSENGER RNA; MITOGENIC AGENT; PROTEIN C MPL; THROMBOPOIETIN; THROMBOPOIETIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ERYTHROID CELL; GENETIC TRANSFECTION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0842330663     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2003.10.015     Document Type: Article

References (41)

1. Sieff C. Hematopoietic growth factors. J Clin Invest. 79:1987;1549-1557.
2. Metcalf D. The granculocyte-macrophage colony stimulating factors. Science. 229:1985;16-22.
3. Toksoz D., Zsebo K.M., Smith K.A., et al. Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor. Proc Natl Acad Sci U S A. 89:(16):1992;7350-7354.
4. Feldman L., Frazier J., Sytkowski A. B lymphocyte derived burst promoting activity (B-BPA) is a pleiotropic erythroid colony stimulating factor, E-CSF. Exp Hematol. 20:1992;1223-1228.
5. Kaushansky K., Brody V., Grossman A., et al. Thrombopoietin expands erythroid progenitors, increases red cell production and enhances red cell recovery after myelosuppressive therapy. J Clin Invest. 96:1995;1683-1687.
6. Kobayashi M., Laver J., Kato T., Miyazaki H., Ogawa M. Recombinant human thrombopoietin (mpl ligand) enhances proliferation of erythroid progenitors. Blood. 86:1995;2494-2499.
7. Lok S., Kaushansky K., Holly R., et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature. 369:1994;565-568.
8. Wada T., Nagata Y., Nagahisa H., et al. Characterization of truncated thrombopoietin variants. Biochem Biophys Res Commun. 213:1995;1091-1098.
9. Alexander W., Metcalf D., Dunn A. Point mutations within a dimer interface homology domain of c-mpl induce constitutive receptor activity and tumorigenicity. European Molecular Biology Organization Journal. 14:1995;5569-5578.
10. Blajchman M., Bordin J., Bardossy L., Heddle N. The contribution of the haematocrit to thrombocytopenic bleeding in experimental animals. Br J Haematol. 86:1994;347-350.
11. Fibbe W., Heemskerk D., Laterveer L., et al. Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood. 86:1995;3308-3313.
12. McDonald T., Sullivan P. Megakaryocytic and erythrocytic cell lines share a common precursor cell. Exp Hematol. 21:1993;1316-1320.
13. Nagata Y., Nagahisa H., Aida Y., Okutomi K., Nagasawa T., Todokoro K. Thrombopoietin induces megakaryocyte differentiation in hematopoietic progenitor FDC-P2 cells. J Biol Chem. 270:1995;19673-19675.
14. Debili N., Coulombel L., Croisille L., et al. Characterization of a bipotential erythro-megakaryocytic progenitor in human bone marrow. Blood. 88:1996;1284-1296.
15. Vannucchi A., Paoletti F., Linari S., et al. Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice. Blood. 95:2000;2559-2568.
16. Longmore G., Pharr P., Neumann D., Lodish H. Both megakaryocytopoiesis and erythropoiesis are induced in mice infected with a retrovirus expressing an oncogenic erythropoietin receptor. Blood. 82:1993;2386-2395.
17. Vigon I., Dreyfuss F., Melle J., et al. Expression of the c-mpl proto-oncogene in human hematological malignancies. Blood. 82:1993;877-883.
18. Cocault L., Bouscary D., LeBousse Kerdiles C., et al. Ectopic expression of murine TPO receptor (c-mpl) in mice is pathogenic and induces erythroblastic proliferation. Blood. 88:1996;1656-1665.
19. Kieran M., Perkins A., Orkin S., Zon L. Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 93:1996;9126-9131.
20. Papayannapoulou T., Brice M., Farrer D., Kaushansky K. Insights into the cellular mechanisms of erythropoietin-thrombopoietin synergy. Exp Hematol. 24:1996;660-669.
21. Tanimukai S., Kimura T., Sakabe H., et al. Recombinant human c-mpl ligand (thrombopoietin) not only acts on megakaryocyte progenitors but also on erythroid and multipotential progenitors in vitro. Exp Hematol. 25:1997;1025-1033.
22. Liu W., Wang M., Tang D., Ding I., Rodgers G. Thrombopoietin has a differentiative effect on late-stage human erythropoiesis. Br J Haematol. 105:1999;459-469.
23. Ratajczak M., Ratajczak J., Marlicz W., et al. Recombinant human thrombopoietin (TPO) stimulates erythropoiesis by inhibiting erythroid progenitor cell apoptosis. Br J Haematol. 98:1997;8-17.
24. Feldman L., Davis K. Thrombopoietin has direct mitogenic effects on the growth of normal and transformed erythroid progenitors. Blood. 88:1996;61a.
25. Bailey S., Feldman L., Romanowski R., Davis K., Sytkowski A. Anti-peptide antibodies as probes of the recombinant and endogenous murine erythropoietin receptors. Exp Hematol. 21:1993;1535-1543.
26. Palacios R., Steinmetz M. IL-3 dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-like configuration, and generate B lymphocytes in vivo. Cell. 41:1985;727-734.
27. Feldman L., Davis K., Feeley D., Sytkowski A. A sensitive new bioassay for erythroid colony stimulating factor. Exp Hematol. 21:1993;1657-1662.
28. Hansen M., Nielson S., Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods. 119:1989;203-210.
29. Feldman L., Cohen C., Riordan M., Dainiak N. Purification of a membrane-derived human erythroid growth factor. Proc Natl Acad Sci U S A. 84:1987;6775-6779.
30. Lowry O., Rosebrough N., Farr A., Randall R. Protein measurement with the Folin phenol reagent. J Biol Chem. 193:1951;265-275.
31. Laemmli U. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1977;680-685.
32. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gells to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A. 76:1979;4350-4354.
33. Winkelmann J., Penny L., Deaven L., Forget B., Jenkins R. The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p. Blood. 76:1990;24-30.
34. Dugaiczyk A., Haron J., Stone E., Dennison O., Rothblum K., Schwartz R. Cloning and sequencing of a deoxyribonucleic acid copy of glyceraldehyde-3- phosphate dehydrogenase messanger ribonucleic acid isolated from chicken muscle. Biochemistry. 22:1983;1605-1613.
35. Krosl J., Damen J., Krystal G., Humphries R. Erythropoietin and interleukin-3 induce distinct events in erythropoietin receptor-expressing Ba/ F3 cells. Blood. 85:1995;50-56.
36. Liboi E., Carroll M., D'Andrea A., Mathey-Prevot B. Erythropoietin receptor signals both proliferation and erythroid-specific differentiation. Proc Natl Acad Sci U S A. 90:1993;11351-11355.
37. Jubinsky P., Krijanovski O., Nathan D., Tavernier J., Sieff C. The β chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. Blood. 90:1997;1867-1873.
38. Krosl J., Damen J., Krystal G., Humphries R. Interleukin-3 (IL-3) inhibits erythropoietin-induced differentiation in BaFe cells via the IL-3 receptor α subunit. J Biol Chem. 271:1996;27432-27437.
39. Morella K., Bruno E., Kumaki S., et al. Signal transduction by the receptors for thrombopoietin (c-mpl) and interleukin-3 in hematopoietic and nonhematopoietic cells. Blood. 86:1997;557-571.
40. Broudy V., Lin N., Sabath D., Papayannapoulou T., Kaushansky K. Human platelets display high-affinity receptors for thrombopoietin. Blood. 89:1997;1896-1904.
41. Ghaffari S., Wu H., Gerlach M., Yan Y., Lodish H., Daley G. BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid developement in erythropoietin receptor-deficient progenitors cells. Proc Natl Acad Sci U S A. 96:1999;13186-13190.