Epidermal Growth Factor-Responsive Laryngeal Squamous Cancer Cell Line Hep2 Is More Sensitive Than Unresponsive CO-K3 One to Quercetin and Tamoxifen Apoptotic Effects

Oncology Research

Volumn 14, Issue 2, 2003, Pages 83-91

  Raspaglio, G ^a   Ferrandina, G ^a   Ferlini, C ^a   Scambia, G ^a   Ranelletti, Franco O ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Apoptosis; Epidermal growth factor; Mitogen activated protein kinases; Quercetin; Tamoxifen

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANTIBODY; ANTINEOPLASTIC AGENT; CHEMOPREVENTIVE AGENT; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; P38 ANTIBODY; PROTEIN; PROTEIN P42; PROTEIN P44; PROTEIN P46; QUERCETIN; SYNAPTOPHYSIN; TAMOXIFEN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CARCINOMA CELL; CELL STRAIN; CELL STRAIN CO K3; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DEPHOSPHORYLATION; DOSE TIME EFFECT RELATION; DRUG POTENTIATION; DRUG SENSITIVITY; DYSPLASIA; GENE OVEREXPRESSION; GROWTH STIMULATION; HEP 2 CELL; HUMAN; HUMAN CELL; LARYNX CANCER; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SQUAMOUS CELL CARCINOMA;

EID: 0842327353     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000003108748630     Document Type: Article

References (24)

1. Salomon, D. S.; Brandt, R.; Ciardiello, F.; Normanno, N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19:183-232; 1995.
2. Hansen, L. A.; Woodson, R. L., 2nd; Holbus, S.; Strain, K.; Lo, Y. C.; Yuspa, S. H. The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors. Cancer Res. 60(13):3328-3332; 2000.
3. Santini, J.; Formento, J. L.; Francoual, M.; Milano, G.; Schneider, M.; Dassonville, O.; Demard, F. Characterization, quantification, and potential clinical value of the epidermal growth factor receptor in head and neck squamous cell carcinomas. Head Neck 13(2):132-139; 1991.
4. Grandis, J. R.; Tweardy, D. J. Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res. 53(15): 3579-3584; 1993.
5. Nagatzuka, H.; Ishiwari, Y.; Tsujigiwa, H.; Nakano, K.; Nagai, N. Quantitation of epidermal growth factor receptor gene amplification by competitive polymerase chain reaction in pre-malignant and malignant oral epithelial lesions. Oral. Oncol. 37(7):599-604; 2001.
6. Gale, N.; Zidar, N.; Kambic, V.; Poljak, M.; Cor, A. Epidermal growth factor, c-erbB-2 and p53 overexpression in epithelial hyperplastic lesions of the larynx. Acta Otolaryngol. Suppl. 527:105-110; 1997.
7. Almadori, G.; Cadoni, G.; Cattani, P.; Galli, J.; Bussu, F.; Ferrandina; G., Scambia, G.; Fadda, G.; Maurizi, M. Human papillomavirus infection and epidermal growth factor receptor expression in primary laryngeal squamous cell carcinoma. Clin. Cancer Res. 7(12):3988-3993; 2001.
8. Ferrandina, G.; Al madori, G.; Maggiano, N.; Lanza, P.; Ferlini, C.; Cattani, P.; Piantelli, M.; Scambia, G.; Ranelletti, F. O. Growth inhibitory effect of tamoxifen and quercetin and presense of type II estrogen binding sites in human laryngeal cancer cell lines and primary laryngeal tumors. Int. J. Cancer 77:747-754; 1998.
9. Zhao, X.; Xiao, X.; Liu J. Effects of sexual hormones on proliferation of laryngeal carcinoma cell line Hep2 in vitro. Chung Hua Erh Pi Yen hon Ko Tsa Chih 29:149-151; 1994.
10. Westermarck, J.; Song-Ping, L.; Tuula, K.; Jiahuai, H.; Veli-Matti, K. p38 mitogen activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression. Mol. Cell. Biol. 21(7):2373-2383; 2001.
11. Ranelletti, F. O.; Almadori, G.; Rocca, B.; Ferrandina, G.; Ciabattoni, G.; Habib, A.; Galli, J.; Maggiano, N.; Gessi, M.; Lauriola, L. Prognostic significance of cyclooxygenase-2 in laryngeal squamous cell carcinoma. Int. J. Cancer 95(6):343-349: 2001.
12. Xia, Z.; Dickens, M.; Raingeaud, J.; Davis, R. J.; Greenberg, M. E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270(5240):1326-1331; 1995.
13. Bonni, A.; Brunet, A.; West, A. E.; Datta, S. R.; Takasu, M. A.; Greenberg, M. E. Cell survival promoted by Ras-MAPK signalling pathway by transcription-dependent and independent mechanisms. Science 286:1358-1362; 1999.
14. Jost, M.; Hugget, T. M.; Kari, C.; Boise, L. H.; Rodeck, U. Epidermal growth factor receptor-dependent control of keratinocyte survival and Bcl-xL expression through a MEK-dependent pathway. J. Biol. Chem. 276:6320-6326; 2001.
15. Tran, S. E.; Holmstrom, T. H.; Ahonem, M.; Kahari, V. M.; Eriksson, J. E. Mitogen-activated protein kinase (MAPK/ERK) overrides the apoptotic signaling from FAS, TNF, and TRAIL receptors. J. Biol. Chem. 276:16484-16490; 2001.
16. Zhang, C. C.; Shapiro, D. J. Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis. J. Biol. Chem. 275(1):479-486; 2000.
17. Han, J.; Lee, J. B.; Bibbs, L.; Ulevitch, R. J. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265:808-811; 1994.
18. Chen, Y. R.; Wang, X.; Templeton, D.; Davis, R. J.; Tan, T. H. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J. Biol. Chem. 271:31929-31936; 1996.
19. Tanoue, T.; Moriguchi, T.; Nishida, E. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. J. Biol. Chem. 247(28):19949-19956; 1999.
20. Richter, M.; Ebermann, R.; Marian, B. Quercetin-induced apoptosis in colorectal tumor cells: Possible role of EGF receptor signaling. Nutr. Cancer 34(1):88-99; 1999.
21. Hollman, P. C. H.; van Trijp, J. M. P.; Mengelers, M. J. B.; de Vries, J. H.; Katan, M. B. Bioavailability of the dietary antioxidant flavonol quercetin in man. Cancer Lett. 114: 139-140; 1997.
22. Muller, K. M.; Krohn, B. R. Smoking habits and their relationship to precancerous lesions of the larynx. J. Cancer Res. Clin. Oncol. 96(2):211-217; 1980.
23. Johnston, D.; Hall, H.; Di Lorenzo, T. P.; Steinberg, B. M. Elevation of the epidermal growth factor receptor and dependent signaling in human papillomavirus-infected laryngeal papillomas. Cancer Res. 59(4):968-974; 1999.
24. Grandis, J. R.; Tweardy, D. J.; Melhem, M. F. Asynchronous modulation of transforming growth factor alpha and epidermal growth factor receptor protein expression in progression of premalignant lesions to head and neck squamous cell carcinoma. Clin. Cancer Res. 4(1):13-20; 1998.