Laminin-5γ2: A Marker to Identify Oral Mucosal Lesions at Risk for Tumor Development?

Anticancer Research

Volumn 23, Issue 6 D, 2003, Pages 4985-4989

  Nordemar, Sushma ^a   Högmo, Anders ^a   Lindholm, Johan ^a   Auer, Gert ^a   Munck Wikland, Eva ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Laminin 5; Oral squamous cell carcinoma; Permalignant oral lesions

Indexed keywords

BIOLOGICAL MARKER; KALININ; LAMININ; LAMININ 5GAMMA2; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BASEMENT MEMBRANE; CANCER INVASION; CANCER PATIENT; CANCER RISK; CARCINOMA IN SITU; CLINICAL ARTICLE; CONTROLLED STUDY; FOLLOW UP; HEAD AND NECK CANCER; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; MOUTH MUCOSA; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA IN SITU; CELL ADHESION MOLECULES; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; MOUTH MUCOSA; MOUTH NEOPLASMS; PRECANCEROUS CONDITIONS; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0842321844     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Silverman SJ and Gorsky M: Epidemiologic and demographic update in oral cancer: California and national data-1973 to 1985. J Am Dent Assoc 120: 495-499, 1990.
2. Ferlay J, Bray F, Pisani P and Parkin DM: GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide, IARC Cancerbase No 5. Lyon, IARCPress, 2001.
3. Lind P: Malignant transformation in oral leukoplakia. Scand J Dent Res 95: 449-455, 1987.
4. Lumerman H, Freedman P and Kerpel S: Oral epithelial dysplasia and the development of invasive squamous cell carcinoma. Oral Sur Oral Med Oral Pathol Oral Radiol Endod 7: 321-329, 1995.
5. Högmo A, Munck-Wikland E, Kuylenstierna R, Lindholm J and Auer G: Nuclear DNA content and immunostaining in metachronous preneoplastic lesions and subsequent carcinomas of the oral cavity. Head Neck 18: 433-440, 1996.
6. Burgesson R, Chiquet M, Deutzman R, Ekblom P, Ehgel J, Kleinman H et al: A new nomenclature for the laminins. Matrix Biol 14: 209-11, 1994.
7. Colognato H and Yurchenko PD: Form and function: The laminin family of heterotrimers. Dev Dyn 218: 213-234, 2000.
8. Engvalle E and Wewer UM: Domains of laminin. J Cell Biochem 61: 493-501, 1996.
9. Pyke C, Romer J, Kallunki P, Lund L, Ralfkiaer E, Dano K and Tryggvasson K: The γ2 chain of Kalinin/Laminin-5 is preferentially expressed in invading malignant cells in human cancers. Amer J Path 145: 782-791, 1994.
10. Pyke C, Salo S Ralfkiaer E, Romer J, Dano K and Tryggvason K: Laminin-5 is a marker of invading cancer cells in some human carcinomas and is co-expressed with the receptor for urokinase plasminogen activator in colon adenocarcinomas. Cancer Res 55: 4132-4139, 1995.
11. Skyldberg B et al: Laminin-5 as a marker of invasiveness in cancer in situ cervical lesions. J Nat Cancer Instit 91: 1882-1887, 1999.
12. SoiniY, Maatta M, Salo S, Tryggvasson K and Harmainen H: Expression of the laminin gamma 2 chain in pancreatic adenocarcinoma. J Pathol 180: 290-294, 1996.
13. Sordat I, Bosman FT, Dorta G, Rouselle P, Aberdam D, Blum AL et al: Differential expression of laminin-5 subunits and integrin receptors in human colorectal neoplasia. J Pathol 185: 44-52 1998.
14. Ono Y, Nakanishi Y, Ino Y, Niki T, Yamada T, Yoshimura K, Saikawa M, Nakajima T and Hirohashi S: Clinicopathologic significance of laminin-5 γ2 chain expression in squamous cell carcinoma of the tongue. Cancer 85: 2315-2321, 1999.
15. Nordemar S, Kronenwett U, Auer G, Högmo A, Lindholm J, Edström S, Tryggvasson K, Linder S and Munck-Wikland E: Laminin-5 as a predictor of invasiveness in cancer in situ lesions of the larynx. Anticancer Res 21: 509-512, 2001.
16. Salo S, Haakana H, Kontusaari S, Hujanen E, Kallunki T and Tryggvasson K. Laminin-5 promotes adhesion and migration of epithelial cells: identification of migration-related element in the gamma 2 chain gene (LAMC2) with activity in transgenic mice. Matrix Biol 18: 197-210, 1999.
17. Silverman S, Meir G and Lozada F: Oral leukoplakia and malignant transformation, a follow-up study of 257 patients. Cancer 53: 563-568, 1984.
18. Högmo A, Lindskog S, Lindholm J, Kuylenstierna R, Auer G and Munck-Wikland E. The clinical value of image cytometry DNA-analysis, p53 and p21/WAF 1 expression. Anticancer Res 18: 3645-3650, 1998.
19. Lenander C, Roblick UJ, Öst A, Tryggvasson K and Auer G. Laminin-5γ2 chain expression correlates with unfavorable prognosis in colon carcinomas. Anal Cell Path 22: 201-209, 2001.
20. Kohlberger P, Beneder CH, Horvat R, Leodolter S and Breitenecker G: Immunohistochemical expression of laminin-5 in cervical intraepithelial neoplasia. Gynecol Oncol 89: 391-394, 2003.