Nuclear DNA content and p53 immunostaining in metachronous preneoplastic lesions and subsequent carcinomas of the oral cavity

Head and Neck

Volumn 18, Issue 5, 1996, Pages 433-440

  Högmo, Anders ^a   Munck Wikland, Eva ^a   Kuylenstierna, Richard ^a   Lindholm, Johan ^a,b   Auer, Gert ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b DANDERYD HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS DNA; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CLINICAL FEATURE; DNA CONTENT; DNA DETERMINATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LEUKOPLAKIA; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

EID: 0029775770     PISSN: 01486403     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-0347(199609/10)18:5<433::aid-hed6>3.0.co;2-6     Document Type: Article

References (25)

1. Lind P. Malignant transformation in oral leukoplakia. Scand J Dent Res 1987;95:449-455.
2. Silverman S, Meir G, Lozada F. Oral leukoplakia and malignant transformation, a follow-up study of 257 patients. Cancer 1984;53:563-568.
3. Einhorn J, Wersäll J. Incidence of oral carcinoma in patients with leukoplakia of the oral mucosa. Cancer 1967;20:2189-2193.
4. Högmo A, Munck-Wikland E, Kuylenstierna R, Lindholm J, Auer G. Nuclear DNA content and p53 immunostaining in oral squamous cell carcinoma - an analysis of a consecutive 10-year material. Int J Oncol 1994;5:915-920.
5. Bartek J, Bartkova J, Vojtesek B, et al. Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene 1991;6:1699-1703.
6. Field JK, Spandidos DA, Malliri A, Gosney JR, Yiagnisis M, Stell PM. Elevated p53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck. Br. J. Cancer 1991;64:573-577.
7. Dolcetti R, Doglioni C, Maestro R, et al. p53 Overexpression is an early event in the development of the human squamous-cell carcinoma of the larynx, genetic and prognostic implications. Int. J. Cancer 1992;52:178-182.
8. Hall P, Ray A, Lemoine N, Midgeley C, Karusz T, Lane D. p53 immunostaining as a marker of malignant disease in diagnostic cytopathology. Lancet 1991;338:513.
9. Sidransky D, Boyle J, Koch W. Molecular screening. Prospects for a new approach. Arch Otolaryngol Head Neck Surg 1993;119:1187-1190.
10. Harris C, Hollstein M. Clinical implications of the p53 tumor-suppressor gene. N Engl J Med 1993;18:1318-1327.
11. WHO Collaborating Centre for Oral Precancerous Lesions. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg 1978;46:518-539.
12. Gaub J, Auer G, Zetterberg A. Quantitative cytochemical aspects of a combined Feulgen naphtol yellow S staining procedure for the simultaneous determination of nuclear and cytoplasmatic proteins and DNA in mammalian cells. Exp. Cell Res. 1975;92:323-332.
13. Pignatelli M, Stamp GWH, Kafiri G, Lane D, Bodmer WF. Over-expression of p53 nuclear oncoprotein in colorectal adenomas. Int J Cancer 1992;50:683-688.
14. Munck-Wikland E, Kuylenstierna R, Lind M, Lindholm J, Nathanson A, Auer G. The prognostic value of cytometric DNA analysis in early stage tongue cancer. Oral Oncol Eur J Cancer 1992;28B:135-138.
15. Norris CM, Cady B. Head, neck and thyroid cancer. In: Holleb AI, ed. American Cancer Society Textbook of Clinical Oncology, 1st ed. American Cancer Society, 1991, p. 306.
16. Reid BJ, Haggit RC, Rubin CE, et al. Observer variation in the diagnosis of dysplasia in Barrett's esophagus. Hum Pathol 188;19:166-178.
17. Munck-Wikland E, Kuylenstierna R, Lindholm J, Auer G. Image cytometry DNA analysis of dysplastic squamous epithelial lesions in the larynx. Anticancer Res 1991; 11:597-600.
18. Böcking A, Auffermann W, Vogel H, Schlöndorff G, Goebbels R. Diagnosis and grading of malignancy in squamous epithelial lesions of the larynx with DNA cytophotometry. Cancer 1985;56:1600-1604.
19. Welkoborsky HJ, Mann W, Gluckman J, Freije J. Quantitative DNA measurements in malignant and benign lesions of the upper aerodigestive tract. ORL 1992;54: 264-269.
20. Pavelic Z, Li Y.-Q., Stambrook P, et al. Overexpression of p53 protein is common in premalignant head and neck lesions. Anticancer Res 1994;14:2259-2266.
21. Dorman A, Walsh T, Droogan O, et al. DNA quantification of squamous cell carcinoma of the oesophagus by flow cytometry and cytophotometric image analysis using formalin fixed paraffin embedded tissue. Cytometry 1992;13: 886-892.
22. Shin D, Kim J, Ro J, et al. Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis. Cancer Res 1994;54:321-326.
23. Nees M, Homann N, Discher H, et al. Expression of mutated p53 occurs in tumor distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors. Cancer Res 1993;53: 4189-4196.
24. Koch W, Boyle J, Mao L, Hakim J, Hruban R, Sidransky D. p53 gene mutations as markers of tumor spread in synchronous oral cancers. Arch Otolaryngol Head Neck Surg 1994;120:943-947.
25. Xu L, Chen Y, Huvos A, et al. Overexpression of p53 protein in squamous cell carcinomas of head and neck without apparent gene mutations. Diagnost Molec Pathol 1994; 3:83-92.