Domiciliary chemotherapy with gemcitabine is safe and acceptable to advanced non-small-cell lung cancer patients: Results of a feasibility study

British Journal of Cancer

Volumn 89, Issue 12, 2003, Pages 2190-2196

  Anderson, H ^a   Addington Hall, J M ^b   Peake, M D ^c   McKendrik, J ^d   Keane, K ^d   Thatcher, N ^a,e  

^a WYTHENSHAWE HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c GLENFIELD HOSPITAL   (United Kingdom)

^d ELI LILLY AND COMPANY   (United States)

^e CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

Advanced NSCLC; Domiciliary; Gemcitabine

Indexed keywords

ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE; DRUG DERIVATIVE; GEMCITABINE;

ADULT; AGED; ALOPECIA; ANOREXIA; ARM PAIN; ARTICLE; BLEEDING; CANCER CHEMOTHERAPY; CANCER STAGING; CLINICAL ARTICLE; CONSTIPATION; CONTROLLED STUDY; COUGHING; DIARRHEA; DISEASE COURSE; DRUG SAFETY; DYSPHAGIA; DYSPNEA; FEASIBILITY STUDY; FEMALE; FEVER; HEMATURIA; HEMOPTYSIS; HOME CARE; HOSPITAL MANAGEMENT; HUMAN; INFECTION; INSOMNIA; LETHARGY; LUNG NON SMALL CELL CANCER; LUNG TUMOR; MALE; NAUSEA; PAIN; PATHOLOGY; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; QUALITY OF LIFE; SHOULDER PAIN; SIDE EFFECT; SOCIAL WELFARE; THORAX PAIN; TREATMENT OUTCOME; VOMITING;

AGED; ANTIMETABOLITES, ANTINEOPLASTIC; CARCINOMA, NON-SMALL-CELL LUNG; DEOXYCYTIDINE; FEASIBILITY STUDIES; FEMALE; HOME CARE SERVICES; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; QUALITY OF LIFE; TREATMENT OUTCOME;

EID: 0842287249     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6601420     Document Type: Article

References (23)

1. Aapro MS, Martin C, Hatty S (1998) Gemcitabine: a safety review. Anticancer Drugs 9: 191-201
2. Anderson H, Hopwood P, Stephens RJ, Thatcher N, Cottier B, Nicholson M, Milroy R, Maughan TS, Falk SJ, Bond MG, Burt PA, Connolly CK, McIllmurray MB, Carmichael J, on Behalf of the UK NSCLC Gemcitabine Group (2000) Gemcitabine plus best supportive care (BSC) vs BSC in inoperable non-small cell lung cancer - a randomized trial with quality of life as the primary outcome. Br J Cancer 83: 447-453
3. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JCJM, Kaasa S, Klee M, Osoba D, Razavi D, Rofe PB, Schraub S, Sneeuw K, Sullivan M, Takeda F (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85: 365-376
4. Carers (Recognition and Services Act(c.12) HMSO Government UK Act) (1995) http://www.hmso.gov.uk/acts/acts1995/Ukpga-19950012-en-1.htm
5. Cullen MH, Billingham LJ, Woodroffe CM, Chetiyawardana AD, Gower NH, Joshi R, Ferry DR, Rudd RM, Spiro SG, Cook JE, Trask C, Bessell E, Connolly CK, Tobias J, Souhami RL (1999) Mitomycin, ifosphamide and cisplatin in unresectable non-small-cell lung cancer: effects on survival and quality of life. J Clin Oncol 17: 3188-3194
6. Goldberg DP, Hillier VF (1979) A scaled version of the General Health Questionnaire. Psychol Med 9: 139-145
7. Grande GE, Addington-Hall JM, Todd CJ (1998) Place of death and access to home care services: are certain patient groups at a disadvantage? Soc Sci Med 47: 565-579
8. Hunt SM, Mckenna SP, McEwen J (1993) The Nottingham Health Profile User's Manual. Manchester, UK: Galen Research
9. Lowenthal RM, Piaszczyk A, Arthur GE, O'Malley S (1996) Home chemotherapy for cancer patients: cost analysis and safety. Med J Aust 165: 184-187
10. Noble S, Goa KL (1997) Gemcitabine: a review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer. Drugs 54: 447-472
11. Non-Small Cell Lung Cancer Collaborative Group (1995) Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individuals from 52 randomised clinical trials. Br Med J 311: 899-909
12. Osoba D, Rodrigues G, Myles J, Zee B, Pater J (1998) Interpreting the significance of changes in health-related quality-of-life scores. J Clin Oncol 16: 139-144
13. Ranson M, Davidson N, Nicolson M, Falk S, Carmichael J, Lopez P, Anderson H, Gustafson N, Jeynes A, Gallant G, Washington T, Thatcher N (2000) Randomized trial of paclitaxel plus supportive care versus supportive care for patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 92: 1074-1080
14. Robinson BC (1983) Validation of a caregiver strain index. J Gerontol 38(3): 344-348
15. Roszkowski K, Pluzanska A, Krzakowski M, Smith AP, Saigi E, Aasebo U, Parisi A, Tran NP, Olivares R, Berille J (2000) A multicentre, randomized, phase III study of docetaxel plus best supportive care versus best supportive care in chemotherapy-naive patients with metastatic or non-resectable localized non-small cell lung cancer (NSCLC). Lung Cancer 27: 145-157
16. Sato K, Takahashi T, Ashikaga K, Hanyu N, Aoki T (1996) Clinical study of home hepatic arterial infusion chemotherapy for liver metastasis from colorectal cancer. Gan To Kagaku Ryoho 23(Suppl 3): 252-255
17. Silvestri G, Pritchard R, Welch HG (1998) Preferences for chemotherapy in patients with advanced non-small cell lung cancer: descriptive study based on scripted interviews. Br Med J 317: 771-775
18. Slevin ML, Stubbs L, Plant HJ, Wilson P, Gregory WM, Armes PJ, Downer SM (1990) Attitudes to chemotherapy: comparing views of patients with cancer with those of doctors, nurses and general public. Br Med J 300: 1458-1460
19. Stockelberg D, Lehtola P, Noren I (1997) Palliative treatment at home for patients with haematological disorders. Support Care Cancer 5: 506-508
20. Thatcher N, Anderson H, Betticher DC, Ranson M (1995a) Symptomatic benefit from gemcitabine and other chemotherapy in advanced non-small cell lung cancer: changes in performance status and disease related symptoms. Anticancer Drugs 6(Suppl 6): 39-48
21. Thatcher N, Hopwood P, Anderson H (1997) Improving quality of life in patients with non-small cell lung cancer: research experience with gemcitabine. Eur J Cancer 33: 8-13
22. Thatcher N, Ranson M, Lee SM, Niven R, Anderson H (1995b) Chemotherapy in non-small cell lung cancer. Ann Oncol 6(Suppl 1): S83-S95
23. The Elderly Lung Cancer Vinorelbine Italian Study Group (1999) Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 91: 66-72