An Efficient Synthesis of a Key Intermediate for the Biologically Active Vitamin D Analogue, Seocalcitol

Organic Process Research and Development

Volumn 8, Issue 1, 2004, Pages 133-135

  Sabroe, Thomas Peter ^a   Pedersen, Henrik ^a   Binderup, Ernst ^a  

^a LEO Pharma ^*  (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BROMINE DERIVATIVE; MAGNESIUM DERIVATIVE; SEOCALCITOL; VITAMIN D DERIVATIVE;

ARTICLE; DRUG ISOLATION; DRUG MANUFACTURE; DRUG SYNTHESIS; ISOMERIZATION; PRODUCTIVITY; QUANTUM YIELD;

EID: 0842285263     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op030037e     Document Type: Article

References (8)

1. (a) Hansen, C. M.; Maenpaa, P. H. Biochem. Pharmacol. 1997, 54, 1173-1179.
2. (b) Hansen, C. M.; Hamberg, K. J.; Binderup, E.; Binderup, L. Curr. Pharm. Des. 2000, 6, 803-828.
3. Calverley, M. J. Tetrahedron 1987, 43, 4609-4619.
4. Binderup, E.; Calverley, M. J.; Binderup, L. Vitamin D: Gene Regulation, Structure-Function Analysis and Clinical Application. In Proceedings of the 8th Workshop on Vitamin D, July 5-10, Paris; 1991; pp 192-193.
5. Binderup, E.; Calverley, M. J. PCT Pat. Appl. No. WO91/00855, 1991.
6. Imamoto, T.; Yokoyama, M. J. Chem. Soc., Chem. Commun. 1982, 1042-1044.
7. Imamoto, T.; Takiyama, N.; Nakamura K.; Hatajima, T.; Kamiya, Y. J. Am. Chem. Soc. 1989, 111, 4392-4398.
8. 3: the material should be dissolved in water or acid solution before disposal.